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OPENSEQ.org

HSLR - Heat shock protein 15
UniProt: P0ACG8 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12929
Length: 133 (126)
Sequences: 720
Seq/Len: 5.71

HSLR
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_I 86_E 3.145 1.00
76_R 80_E 2.654 1.00
69_K 86_E 2.647 1.00
20_F 66_V 2.42 1.00
72_T 84_L 2.113 1.00
21_Y 57_L 2.1 1.00
54_T 65_T 1.974 1.00
67_I 88_T 1.939 1.00
114_R 117_D 1.907 1.00
81_A 85_Y 1.811 1.00
117_D 120_E 1.787 1.00
39_N 53_A 1.705 1.00
72_T 76_R 1.703 1.00
51_L 71_I 1.703 1.00
37_H 42_R 1.694 1.00
54_T 67_I 1.683 1.00
58_R 63_E 1.653 1.00
123_D 126_R 1.631 0.99
82_A 85_Y 1.602 0.99
117_D 125_L 1.6 0.99
80_E 83_L 1.583 0.99
100_L 104_L 1.559 0.99
55_L 68_V 1.534 0.99
14_W 18_A 1.531 0.99
77_P 80_E 1.489 0.99
93_E 97_K 1.478 0.99
100_L 103_K 1.429 0.98
32_E 45_P 1.394 0.98
38_Y 53_A 1.382 0.98
45_P 115_R 1.38 0.98
86_E 89_A 1.362 0.98
70_A 83_L 1.356 0.97
59_Q 64_R 1.328 0.97
88_T 91_S 1.297 0.96
120_E 124_L 1.291 0.96
112_P 117_D 1.262 0.96
50_E 53_A 1.244 0.95
49_V 68_V 1.241 0.95
25_A 29_E 1.229 0.95
16_W 44_K 1.222 0.95
109_M 112_P 1.22 0.94
18_A 84_L 1.217 0.94
70_A 84_L 1.192 0.94
118_K 122_R 1.169 0.93
21_Y 59_Q 1.167 0.93
81_A 84_L 1.152 0.92
21_Y 30_M 1.106 0.90
39_N 43_S 1.099 0.89
18_A 85_Y 1.091 0.89
15_L 21_Y 1.061 0.87
123_D 127_F 1.044 0.86
97_K 100_L 1.042 0.86
87_E 91_S 1.037 0.85
49_V 71_I 1.036 0.85
65_T 90_E 1.026 0.84
14_W 85_Y 1.008 0.83
94_K 97_K 1.006 0.83
38_Y 55_L 1.005 0.83
119_K 123_D 1.003 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1dm9A211000.371Contact Map0.871
2k6pA10.691799.50.684Contact Map0.51
4bpeD10.60998.90.769Contact Map0.46
3iz6C10.669298.80.778Contact Map0.019
3u5cJ10.699298.70.784Contact Map0.315
3bbnD10.81298.60.79Contact Map0.402
3zey610.661798.60.791Contact Map0.445
4kiyD10.804598.60.792Contact Map0.302
2cqjA10.503898.50.798Contact Map0.454
1p9kA10.496298.40.801Contact Map0.353

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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