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OPENSEQ.org

HINT - HIT-like protein HinT
UniProt: P0ACE7 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12172
Length: 119 (110)
Sequences: 3237
Seq/Len: 29.43

HINT
Paralog alert: 0.30 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
5_T 8_S 3.552 1.00
25_L 64_R 3.31 1.00
22_Q 45_N 3.048 1.00
8_S 47_L 2.987 1.00
18_D 30_R 2.857 1.00
5_T 47_L 2.763 1.00
13_R 19_I 2.473 1.00
46_I 58_H 2.449 1.00
9_K 14_E 2.164 1.00
20_V 40_I 2.117 1.00
87_M 102_M 2.092 1.00
23_D 64_R 2.009 1.00
27_T 45_N 1.94 1.00
29_F 43_I 1.93 1.00
81_D 92_H 1.926 1.00
19_I 27_T 1.897 1.00
8_S 12_R 1.739 1.00
26_V 64_R 1.705 1.00
42_I 104_L 1.687 1.00
30_R 76_E 1.677 1.00
70_A 74_E 1.552 1.00
26_V 68_V 1.525 1.00
65_M 102_M 1.453 1.00
37_P 108_R 1.446 1.00
19_I 22_Q 1.432 1.00
50_T 53_D 1.387 0.99
17_S 27_T 1.382 0.99
46_I 61_A 1.323 0.99
54_V 100_I 1.308 0.99
56_A 70_A 1.281 0.99
54_V 62_L 1.274 0.99
66_I 102_M 1.264 0.99
56_A 67_T 1.26 0.99
36_A 105_L 1.252 0.99
10_I 17_S 1.233 0.98
21_Y 68_V 1.218 0.98
71_K 75_Q 1.207 0.98
28_A 40_I 1.206 0.98
50_T 89_T 1.195 0.98
69_A 102_M 1.194 0.98
48_I 100_I 1.193 0.98
40_I 72_I 1.168 0.97
30_R 40_I 1.14 0.97
4_E 8_S 1.121 0.97
62_L 66_I 1.119 0.96
46_I 55_S 1.116 0.96
64_R 68_V 1.112 0.96
38_T 106_G 1.111 0.96
78_I 106_G 1.105 0.96
40_I 104_L 1.104 0.96
52_N 83_Y 1.09 0.96
91_R 98_Y 1.09 0.96
82_G 93_G 1.083 0.96
35_Q 96_E 1.082 0.96
86_I 105_L 1.074 0.95
59_E 67_T 1.069 0.95
69_A 85_L 1.049 0.94
27_T 43_I 1.006 0.93
68_V 71_K 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3n1sA811000.16Contact Map0.856
3ksvA10.97481000.186Contact Map0.704
1xquA20.96641000.198Contact Map0.788
4incA20.9581000.199Contact Map0.786
4eguA20.97481000.2Contact Map0.862
3oj7A10.94961000.201Contact Map0.763
3o1cA10.9581000.209Contact Map0.763
2pofA20.96641000.215Contact Map0.416
3lb5A40.97481000.218Contact Map0.826
3l7xA10.97481000.219Contact Map0.761

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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