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OPENSEQ.org
ATP6 - ATP synthase subunit a
UniProt: P0AB98 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10099
Length: 271 (252)
Sequences: 1296
Seq/Len: 5.14
ATP6
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_S 149_V 3.121 1.00
104_L 157_V 2.974 1.00
74_K 77_T 2.951 1.00
108_I 112_V 2.519 1.00
113_F 250_T 2.46 1.00
196_E 199_S 2.459 1.00
48_F 139_L 2.444 1.00
190_P 194_I 2.314 1.00
142_V 215_M 2.26 1.00
105_A 257_M 2.249 1.00
52_L 115_M 2.091 1.00
41_I 46_M 1.956 1.00
55_L 114_L 1.892 1.00
57_L 61_R 1.89 1.00
88_G 92_D 1.799 1.00
162_L 200_L 1.795 1.00
187_A 190_P 1.776 1.00
61_R 65_K 1.765 1.00
151_L 208_G 1.713 1.00
52_L 118_M 1.7 1.00
115_M 143_P 1.685 1.00
173_G 176_K 1.613 0.99
105_A 261_I 1.609 0.99
230_P 235_W 1.6 0.99
151_L 154_A 1.579 0.99
198_V 202_S 1.548 0.99
219_E 245_H 1.535 0.99
58_V 61_R 1.51 0.99
58_V 62_S 1.51 0.99
166_I 175_T 1.505 0.99
77_T 81_L 1.498 0.99
151_L 155_L 1.496 0.99
68_T 73_G 1.446 0.98
188_F 191_V 1.445 0.98
157_V 260_T 1.433 0.98
63_V 75_F 1.413 0.98
144_S 149_V 1.411 0.98
141_V 146_D 1.404 0.98
239_V 243_I 1.386 0.97
179_T 189_I 1.383 0.97
147_V 151_L 1.362 0.97
82_V 110_V 1.355 0.97
241_W 244_F 1.34 0.97
94_Y 265_S 1.335 0.96
119_D 142_V 1.331 0.96
155_L 159_I 1.322 0.96
90_V 261_I 1.313 0.96
62_S 66_K 1.306 0.96
64_A 67_A 1.296 0.96
17_N 20_Q 1.295 0.96
93_M 258_V 1.294 0.96
54_L 58_V 1.293 0.96
169_K 177_E 1.274 0.95
49_S 111_W 1.267 0.95
253_A 256_F 1.259 0.95
126_L 141_V 1.258 0.95
113_F 117_L 1.252 0.94
120_L 242_A 1.25 0.94
171_I 175_T 1.242 0.94
88_G 154_A 1.24 0.94
162_L 166_I 1.224 0.93
54_L 61_R 1.214 0.93
101_I 164_Y 1.212 0.93
59_L 79_I 1.189 0.92
48_F 118_M 1.187 0.92
61_R 64_A 1.18 0.92
55_L 58_V 1.18 0.92
149_V 153_M 1.171 0.91
20_Q 40_T 1.166 0.91
54_L 57_L 1.164 0.91
218_G 245_H 1.163 0.91
189_I 193_L 1.161 0.91
174_F 207_L 1.151 0.90
27_S 30_D 1.15 0.90
240_P 244_F 1.149 0.90
126_L 139_L 1.147 0.90
184_N 187_A 1.146 0.90
152_S 202_S 1.145 0.90
230_P 234_Q 1.136 0.90
256_F 259_L 1.13 0.89
209_L 213_G 1.127 0.89
163_F 167_K 1.125 0.89
89_S 258_V 1.123 0.89
42_N 45_S 1.121 0.89
174_F 267_A 1.119 0.89
142_V 249_I 1.118 0.89
13_G 18_N 1.116 0.88
13_G 17_N 1.113 0.88
109_F 218_G 1.111 0.88
49_S 53_G 1.102 0.88
9_Q 20_Q 1.09 0.87
13_G 27_S 1.089 0.87
2_A 10_D 1.088 0.87
104_L 108_I 1.085 0.87
196_E 200_L 1.082 0.86
180_L 189_I 1.08 0.86
90_V 105_A 1.068 0.85
94_Y 98_S 1.067 0.85
118_M 144_S 1.066 0.85
54_L 82_V 1.061 0.85
9_Q 17_N 1.058 0.85
152_S 241_W 1.053 0.84
53_G 57_L 1.043 0.83
8_P 13_G 1.043 0.83
87_N 102_A 1.036 0.83
9_Q 13_G 1.035 0.83
167_K 246_I 1.031 0.83
20_Q 30_D 1.03 0.82
225_I 241_W 1.029 0.82
92_D 258_V 1.027 0.82
158_F 258_V 1.024 0.82
86_V 258_V 1.02 0.82
114_L 264_L 1.017 0.81
76_Q 170_G 1.012 0.81
231_W 234_Q 1.007 0.80
204_P 261_I 1.004 0.80
230_P 240_P 1.001 0.80
8_P 128_Y 1 0.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1c17M10.65311000.43Contact Map0.183
3q39A20.26577.60.969Contact Map0.187
3lq6A20.25463.30.974Contact Map0.096
2xl1A10.08122.70.975Contact Map0.28
2jpkA10.12552.60.975Contact Map0.5
2k1oA20.12181.80.977Contact Map0.207
2rddB10.13281.70.978Contact Map0.365
4ebrA20.21771.60.978Contact Map0.431
1x93A20.12921.60.978Contact Map0.246
2obsA10.30261.60.978Contact Map0.136
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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