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OPENSEQ.org
LON - Lon protease
UniProt: P0A9M0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10542
Length: 784 (768)
Sequences: 1615
Seq/Len: 2.10
LON
Paralog alert: 0.13 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
716_I 719_L 5.105 1.00
317_Q 321_D 4.765 1.00
738_F 741_K 4.663 1.00
503_K 525_D 4.258 1.00
738_F 761_K 3.948 1.00
307_S 415_V 3.913 1.00
507_L 523_V 3.618 1.00
322_T 371_K 3.572 1.00
343_R 556_V 3.274 1.00
51_M 98_A 3.208 1.00
101_S 115_E 3.174 1.00
733_T 758_H 3.161 1.00
551_L 570_I 3.081 1.00
409_K 420_F 3.049 1.00
500_N 504_R 2.997 1.00
102_A 113_K 2.875 1.00
758_H 769_L 2.835 1.00
632_E 635_Q 2.765 1.00
733_T 756_D 2.745 1.00
256_R 260_A 2.727 1.00
323_D 371_K 2.716 1.00
736_I 759_P 2.712 1.00
558_Q 577_D 2.677 1.00
723_L 757_I 2.677 1.00
258_I 271_A 2.629 1.00
615_T 687_A 2.624 1.00
702_A 731_I 2.617 1.00
530_G 534_Y 2.609 1.00
760_V 765_E 2.589 1.00
727_H 754_D 2.577 1.00
167_D 192_R 2.524 1.00
271_A 298_M 2.513 1.00
700_D 732_K 2.498 1.00
407_I 461_Y 2.497 1.00
99_R 115_E 2.46 1.00
298_M 459_V 2.432 1.00
186_M 191_E 2.378 1.00
749_D 752_I 2.356 1.00
719_L 736_I 2.356 1.00
524_D 527_A 2.343 1.00
507_L 548_I 2.316 1.00
255_K 279_K 2.294 1.00
410_M 461_Y 2.289 1.00
265_K 269_E 2.283 1.00
765_E 768_T 2.281 1.00
182_S 195_Y 2.279 1.00
571_N 574_N 2.255 1.00
428_M 440_L 2.238 1.00
11_I 74_V 2.217 1.00
258_I 275_L 2.213 1.00
531_I 551_L 2.21 1.00
514_N 549_S 2.207 1.00
416_K 461_Y 2.205 1.00
733_T 769_L 2.176 1.00
482_L 487_V 2.17 1.00
307_S 376_K 2.166 1.00
306_R 465_D 2.145 1.00
13_V 112_A 2.117 0.99
268_K 272_E 2.1 0.99
626_Y 638_I 2.094 0.99
531_I 579_L 2.085 0.99
610_L 729_G 2.079 0.99
74_V 98_A 2.065 0.99
301_V 461_Y 2.064 0.99
53_V 68_L 2.064 0.99
735_L 769_L 2.051 0.99
744_L 759_P 2.034 0.99
315_Q 319_I 2.033 0.99
33_R 55_Q 2.031 0.99
315_Q 318_E 2.006 0.99
306_R 416_K 2.001 0.99
749_D 753_A 1.976 0.99
264_P 267_A 1.964 0.99
68_L 100_I 1.959 0.99
682_I 766_V 1.933 0.99
166_A 193_L 1.931 0.99
686_T 766_V 1.927 0.99
595_V 694_G 1.925 0.99
657_D 661_K 1.918 0.99
261_A 305_A 1.906 0.99
53_V 100_I 1.906 0.99
181_Q 185_E 1.883 0.98
499_L 529_I 1.882 0.98
496_D 750_N 1.882 0.98
574_N 578_Y 1.873 0.98
318_E 322_T 1.872 0.98
386_R 455_H 1.85 0.98
378_V 413_V 1.843 0.98
670_E 714_L 1.825 0.98
686_T 697_V 1.807 0.98
510_Q 549_S 1.803 0.98
263_M 271_A 1.795 0.98
523_V 551_L 1.79 0.98
453_S 460_D 1.772 0.97
648_R 764_E 1.76 0.97
510_Q 548_I 1.752 0.97
686_T 770_A 1.749 0.97
13_V 51_M 1.724 0.97
503_K 528_I 1.718 0.97
670_E 708_T 1.712 0.97
354_L 369_I 1.702 0.97
521_L 552_C 1.679 0.96
617_C 691_C 1.676 0.96
621_K 660_E 1.673 0.96
716_I 736_I 1.668 0.96
716_I 723_L 1.665 0.96
524_D 569_E 1.665 0.96
735_L 760_V 1.661 0.96
736_I 744_L 1.655 0.96
263_M 299_V 1.652 0.96
188_D 191_E 1.65 0.96
741_K 759_P 1.646 0.96
530_G 572_G 1.645 0.96
534_Y 582_Q 1.645 0.96
33_R 36_S 1.635 0.95
622_G 663_D 1.63 0.95
685_C 707_I 1.628 0.95
262_K 304_N 1.623 0.95
555_A 568_I 1.599 0.95
527_A 575_L 1.584 0.94
258_I 272_E 1.583 0.94
377_Y 381_A 1.581 0.94
593_N 772_Q 1.581 0.94
230_L 237_I 1.578 0.94
179_D 182_S 1.576 0.94
32_G 36_S 1.575 0.94
648_R 651_K 1.572 0.94
259_D 268_K 1.57 0.94
719_L 723_L 1.569 0.94
386_R 389_A 1.567 0.94
510_Q 545_E 1.565 0.94
615_T 691_C 1.549 0.93
263_M 298_M 1.547 0.93
644_V 763_I 1.54 0.93
682_I 760_V 1.537 0.93
140_G 208_Q 1.534 0.93
499_L 525_D 1.53 0.93
719_L 759_P 1.524 0.93
50_I 75_A 1.521 0.92
57_E 60_T 1.521 0.92
260_A 265_K 1.52 0.92
495_E 533_R 1.519 0.92
378_V 420_F 1.518 0.92
723_L 734_V 1.516 0.92
73_T 94_G 1.509 0.92
255_K 272_E 1.507 0.92
760_V 766_V 1.507 0.92
277_K 293_G 1.503 0.92
685_C 763_I 1.499 0.92
735_L 766_V 1.499 0.92
382_L 422_L 1.498 0.92
17_R 33_R 1.498 0.92
297_W 408_Q 1.497 0.92
71_V 187_S 1.494 0.92
186_M 195_Y 1.49 0.91
120_P 188_D 1.485 0.91
70_T 99_R 1.484 0.91
258_I 263_M 1.483 0.91
416_K 465_D 1.48 0.91
530_G 575_L 1.48 0.91
475_M 487_V 1.477 0.91
479_A 482_L 1.467 0.91
530_G 582_Q 1.466 0.91
723_L 736_I 1.464 0.90
668_V 684_M 1.45 0.90
557_K 561_L 1.45 0.90
593_N 699_A 1.45 0.90
618_V 643_T 1.445 0.90
314_R 561_L 1.443 0.90
555_A 578_Y 1.441 0.90
162_P 193_L 1.434 0.89
522_T 567_H 1.43 0.89
525_D 529_I 1.417 0.88
701_V 733_T 1.41 0.88
695_N 771_L 1.41 0.88
105_D 108_E 1.406 0.88
507_L 528_I 1.404 0.88
60_T 67_D 1.404 0.88
310_K 315_Q 1.402 0.88
554_K 578_Y 1.396 0.87
698_R 733_T 1.395 0.87
234_M 237_I 1.391 0.87
509_K 545_E 1.389 0.87
603_W 725_A 1.385 0.87
176_K 179_D 1.384 0.87
708_T 714_L 1.375 0.86
33_R 63_P 1.374 0.86
500_N 503_K 1.371 0.86
766_V 770_A 1.367 0.86
760_V 769_L 1.366 0.86
269_E 414_G 1.365 0.86
741_K 745_E 1.362 0.86
35_K 62_E 1.357 0.85
526_S 572_G 1.354 0.85
329_R 550_K 1.352 0.85
97_R 192_R 1.35 0.85
494_T 720_K 1.348 0.85
262_K 308_K 1.348 0.85
629_S 632_E 1.345 0.85
261_A 271_A 1.34 0.84
527_A 572_G 1.337 0.84
767_L 771_L 1.335 0.84
30_F 89_K 1.327 0.84
330_V 354_L 1.326 0.84
511_I 521_L 1.326 0.84
558_Q 578_Y 1.325 0.83
508_P 512_E 1.324 0.83
521_L 555_A 1.322 0.83
736_I 757_I 1.319 0.83
576_H 745_E 1.306 0.82
376_K 414_G 1.303 0.82
100_I 112_A 1.302 0.82
682_I 713_V 1.299 0.82
17_R 55_Q 1.297 0.82
100_I 103_L 1.297 0.82
32_G 55_Q 1.293 0.81
271_A 275_L 1.293 0.81
369_I 469_V 1.292 0.81
645_V 689_V 1.29 0.81
223_K 227_E 1.286 0.81
517_K 520_E 1.285 0.81
380_M 409_K 1.276 0.80
366_G 421_L 1.272 0.80
163_A 167_D 1.264 0.79
379_R 485_M 1.263 0.79
723_L 755_L 1.263 0.79
271_A 295_I 1.263 0.79
17_R 32_G 1.262 0.79
179_D 202_S 1.262 0.79
531_I 548_I 1.256 0.79
163_A 166_A 1.256 0.79
664_I 692_L 1.255 0.79
638_I 666_V 1.252 0.78
96_Q 116_Y 1.247 0.78
602_A 611_L 1.242 0.78
689_V 767_L 1.241 0.78
523_V 555_A 1.235 0.77
376_K 415_V 1.23 0.77
18_D 30_F 1.226 0.76
76_S 95_L 1.218 0.76
218_K 222_E 1.218 0.76
707_I 763_I 1.218 0.76
254_L 296_D 1.216 0.76
523_V 548_I 1.215 0.75
558_Q 563_K 1.213 0.75
682_I 685_C 1.211 0.75
366_G 377_Y 1.211 0.75
134_A 193_L 1.208 0.75
289_T 399_I 1.208 0.75
55_Q 63_P 1.204 0.75
752_I 757_I 1.2 0.74
738_F 765_E 1.197 0.74
317_Q 561_L 1.189 0.73
391_I 443_V 1.188 0.73
297_W 411_A 1.188 0.73
162_P 166_A 1.187 0.73
734_V 757_I 1.18 0.72
304_N 416_K 1.179 0.72
101_S 113_K 1.179 0.72
257_K 300_Q 1.176 0.72
255_K 259_D 1.173 0.72
499_L 503_K 1.172 0.72
396_R 458_E 1.17 0.72
36_S 55_Q 1.17 0.72
365_L 490_L 1.167 0.71
216_R 239_K 1.162 0.71
332_D 554_K 1.16 0.71
613_I 683_A 1.158 0.70
574_N 577_D 1.158 0.70
601_L 734_V 1.157 0.70
132_R 203_E 1.156 0.70
167_D 187_S 1.151 0.70
635_Q 639_Q 1.151 0.70
65_V 103_L 1.146 0.69
617_C 662_R 1.146 0.69
281_M 289_T 1.14 0.69
252_E 256_R 1.14 0.69
499_L 532_I 1.139 0.69
559_L 568_I 1.131 0.68
597_Q 612_T 1.131 0.68
18_D 89_K 1.131 0.68
301_V 407_I 1.129 0.68
381_A 577_D 1.129 0.68
761_K 765_E 1.123 0.67
335_L 557_K 1.12 0.67
447_E 509_K 1.116 0.66
17_R 36_S 1.113 0.66
429_S 437_A 1.112 0.66
307_S 655_N 1.112 0.66
555_A 559_L 1.111 0.66
355_V 482_L 1.11 0.66
13_V 98_A 1.106 0.65
258_I 299_V 1.105 0.65
577_D 749_D 1.104 0.65
547_E 550_K 1.102 0.65
654_I 689_V 1.102 0.65
343_R 520_E 1.101 0.65
646_R 658_F 1.1 0.65
126_E 190_N 1.097 0.64
51_M 114_A 1.095 0.64
410_M 413_V 1.095 0.64
689_V 771_L 1.093 0.64
216_R 236_A 1.093 0.64
654_I 693_T 1.092 0.64
609_D 613_I 1.091 0.64
585_D 739_E 1.084 0.63
49_K 76_S 1.081 0.63
144_L 207_L 1.08 0.63
212_R 236_A 1.079 0.62
651_K 764_E 1.078 0.62
265_K 308_K 1.075 0.62
117_L 187_S 1.073 0.62
337_Y 350_P 1.073 0.62
532_I 544_L 1.072 0.62
658_F 692_L 1.069 0.61
137_Q 197_M 1.064 0.61
32_G 63_P 1.062 0.61
625_T 639_Q 1.058 0.60
618_V 646_R 1.057 0.60
630_L 668_V 1.056 0.60
522_T 569_E 1.053 0.60
521_L 551_L 1.052 0.60
475_M 482_L 1.051 0.59
309_V 373_T 1.05 0.59
325_Y 500_N 1.048 0.59
629_S 670_E 1.048 0.59
524_D 573_D 1.047 0.59
310_K 374_G 1.046 0.59
28_P 78_L 1.046 0.59
377_Y 421_L 1.043 0.59
265_K 268_K 1.037 0.58
309_V 417_N 1.036 0.58
17_R 63_P 1.029 0.57
134_A 200_M 1.028 0.57
54_A 69_F 1.026 0.57
129_V 206_L 1.024 0.56
323_D 505_H 1.023 0.56
71_V 117_L 1.023 0.56
348_K 513_R 1.022 0.56
385_V 428_M 1.022 0.56
16_L 52_L 1.02 0.56
53_V 112_A 1.02 0.56
262_K 265_K 1.013 0.55
378_V 385_V 1.012 0.55
763_I 767_L 1.011 0.55
659_Y 692_L 1.011 0.55
313_L 339_A 1.01 0.55
626_Y 635_Q 1.007 0.55
716_I 759_P 1.006 0.54
260_A 308_K 1.003 0.54
354_L 469_V 1.003 0.54
227_E 241_L 1.001 0.54
317_Q 557_K 1.001 0.54
524_D 571_N 1 0.54
323_D 368_S 1 0.54
510_Q 552_C 1 0.54
97_R 167_D 1 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3m6aA60.68751000.587Contact Map0.636
3k1jA20.59691000.779Contact Map0.628
4fwgA10.5511000.803Contact Map0.518
3ljcA10.31251000.835Contact Map0.607
1rreA60.25511000.844Contact Map0.844
2x36A60.25261000.848Contact Map0.842
1xhkA20.2271000.862Contact Map0.775
1z0wA10.24741000.864Contact Map0.738
4gitA20.15821000.865Contact Map0.793
1g41A10.35591000.873Contact Map0.449
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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