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OPENSEQ.org

PPIC - Peptidyl-prolyl cis-trans isomerase C
UniProt: P0A9L5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12352
Length: 93 (91)
Sequences: 3209
Seq/Len: 35.26

PPIC
Paralog alert: 0.67 [within 20: 0.18] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_L 26_K 3.15 1.00
56_G 63_D 2.672 1.00
6_A 49_D 2.632 1.00
24_Q 29_A 2.482 1.00
8_L 90_L 2.432 1.00
53_F 58_M 2.381 1.00
60_P 64_K 2.171 1.00
70_P 73_E 2.024 1.00
15_E 19_L 1.979 1.00
69_C 75_T 1.957 1.00
8_L 88_K 1.916 1.00
6_A 90_L 1.837 1.00
20_D 24_Q 1.819 1.00
71_V 91_Y 1.809 1.00
52_E 91_Y 1.789 1.00
5_A 92_R 1.66 1.00
23_E 27_N 1.646 1.00
21_L 38_H 1.634 1.00
22_L 76_G 1.62 1.00
30_D 33_K 1.593 1.00
13_K 40_I 1.563 1.00
6_A 52_E 1.542 1.00
22_L 86_I 1.517 1.00
5_A 67_F 1.513 1.00
5_A 66_V 1.476 1.00
14_E 17_L 1.428 1.00
69_C 89_V 1.411 1.00
25_I 34_L 1.388 0.99
55_Q 67_F 1.353 0.99
6_A 91_Y 1.345 0.99
59_V 82_F 1.319 0.99
4_T 93_N 1.301 0.99
4_T 52_E 1.29 0.99
79_H 84_Y 1.277 0.99
32_G 47_G 1.27 0.99
33_K 37_K 1.266 0.99
22_L 77_P 1.265 0.99
21_L 34_L 1.251 0.99
29_A 34_L 1.228 0.98
54_R 57_Q 1.205 0.98
78_L 87_I 1.173 0.98
24_Q 38_H 1.156 0.97
34_L 38_H 1.152 0.97
23_E 26_K 1.15 0.97
12_V 21_L 1.135 0.97
19_L 23_E 1.115 0.96
65_V 78_L 1.114 0.96
80_T 83_G 1.113 0.96
17_L 40_I 1.112 0.96
7_A 66_V 1.103 0.96
17_L 38_H 1.097 0.96
9_H 85_H 1.083 0.96
64_K 68_S 1.059 0.95
7_A 53_F 1.057 0.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1jnsA10.989299.90.04Contact Map0.569
3gpkA2199.90.06Contact Map0.799
2pv1A10.978599.90.061Contact Map0.755
1zk6A10.989299.90.068Contact Map0.729
2rqsA10.978599.90.073Contact Map0.591
4g2pA2199.90.076Contact Map0.735
2lj4A10.978599.90.08Contact Map0.755
3ui4A10.989299.90.089Contact Map0.817
2kgjA10.978599.90.09Contact Map0.645
3tc5A10.978599.90.092Contact Map0.822

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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