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OPENSEQ.org
PANE - 2-dehydropantoate 2-reductase
UniProt: P0A9J4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13271
Length: 303 (291)
Sequences: 2230
Seq/Len: 7.66
PANE
Paralog alert: 0.42 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
269_R 279_T 4.538 1.00
268_A 275_V 4.291 1.00
242_I 250_R 3.768 1.00
218_E 271_H 2.956 1.00
16_L 28_G 2.926 1.00
2_K 25_E 2.7 1.00
207_I 281_L 2.697 1.00
4_T 64_S 2.683 1.00
76_V 97_H 2.649 1.00
261_N 278_N 2.62 1.00
66_L 94_L 2.54 1.00
275_V 279_T 2.49 1.00
68_L 94_L 2.473 1.00
265_L 279_T 2.425 1.00
187_T 243_S 2.374 1.00
258_D 286_K 2.32 1.00
214_V 275_V 2.3 1.00
242_I 246_L 2.25 1.00
141_P 148_D 2.246 1.00
180_N 184_N 2.199 1.00
218_E 267_R 2.17 1.00
246_L 250_R 2.093 1.00
88_P 91_T 1.974 1.00
191_N 250_R 1.957 1.00
174_W 215_I 1.935 1.00
267_R 270_A 1.922 1.00
257_I 285_V 1.917 1.00
207_I 277_E 1.907 1.00
8_C 28_G 1.873 1.00
186_L 197_L 1.865 1.00
3_I 155_I 1.862 1.00
96_I 116_G 1.846 1.00
6_L 79_A 1.81 1.00
191_N 246_L 1.794 1.00
188_A 249_I 1.762 1.00
282_F 286_K 1.731 1.00
18_A 21_K 1.73 1.00
168_N 171_A 1.725 1.00
76_V 102_T 1.71 1.00
245_M 248_D 1.701 1.00
178_A 211_V 1.68 1.00
87_L 91_T 1.679 1.00
268_A 273_I 1.664 1.00
109_I 112_P 1.654 1.00
3_I 66_L 1.599 1.00
244_S 248_D 1.534 1.00
181_C 211_V 1.528 1.00
42_V 47_S 1.515 1.00
94_L 114_L 1.489 0.99
214_V 264_L 1.486 0.99
136_I 164_A 1.469 0.99
13_Q 129_I 1.463 0.99
267_R 271_H 1.46 0.99
41_L 47_S 1.459 0.99
66_L 152_L 1.453 0.99
261_N 282_F 1.44 0.99
217_R 271_H 1.397 0.99
125_D 130_I 1.377 0.99
238_T 241_N 1.372 0.99
189_I 284_M 1.37 0.99
255_T 285_V 1.357 0.99
258_D 282_F 1.356 0.99
203_E 280_R 1.354 0.99
138_H 166_H 1.351 0.99
118_T 137_T 1.348 0.99
268_A 274_A 1.347 0.99
94_L 116_G 1.335 0.98
185_P 245_M 1.334 0.98
274_A 279_T 1.334 0.98
211_V 264_L 1.323 0.98
193_P 196_E 1.323 0.98
24_H 158_T 1.322 0.98
265_L 282_F 1.321 0.98
150_S 154_D 1.316 0.98
114_L 149_Y 1.312 0.98
189_I 288_K 1.31 0.98
195_G 239_A 1.288 0.98
92_P 152_L 1.28 0.98
154_D 157_Q 1.265 0.98
6_L 67_L 1.257 0.98
140_G 169_I 1.256 0.97
35_P 38_S 1.252 0.97
273_I 276_P 1.246 0.97
201_P 205_M 1.241 0.97
206_Q 277_E 1.238 0.97
166_H 172_E 1.233 0.97
249_I 255_T 1.231 0.97
286_K 289_E 1.227 0.97
4_T 29_W 1.21 0.97
95_L 106_L 1.207 0.97
72_K 176_K 1.2 0.96
98_N 176_K 1.191 0.96
122_A 129_I 1.19 0.96
117_T 173_L 1.182 0.96
217_R 273_I 1.173 0.96
258_D 266_R 1.171 0.96
14_L 122_A 1.171 0.96
193_P 240_E 1.168 0.96
43_E 131_H 1.163 0.96
76_V 95_L 1.161 0.95
194_N 241_N 1.161 0.95
78_D 81_K 1.156 0.95
11_L 70_T 1.141 0.95
5_V 16_L 1.141 0.95
4_T 67_L 1.14 0.95
190_W 284_M 1.133 0.95
43_E 47_S 1.124 0.94
101_G 104_E 1.11 0.94
92_P 148_D 1.107 0.94
183_I 241_N 1.099 0.93
185_P 261_N 1.098 0.93
9_G 12_G 1.097 0.93
265_L 275_V 1.068 0.92
109_I 113_L 1.066 0.92
120_H 131_H 1.065 0.92
184_N 245_M 1.06 0.92
2_K 65_D 1.059 0.92
67_L 87_L 1.056 0.92
103_I 173_L 1.044 0.91
30_L 36_Y 1.043 0.91
15_W 118_T 1.04 0.91
27_Q 64_S 1.04 0.91
42_V 128_V 1.039 0.91
8_C 16_L 1.037 0.91
99_G 176_K 1.037 0.91
279_T 283_E 1.036 0.90
261_N 264_L 1.034 0.90
266_R 270_A 1.033 0.90
34_Q 37_C 1.032 0.90
73_A 259_Y 1.023 0.90
183_I 194_N 1.02 0.90
17_T 20_C 1.017 0.89
268_A 278_N 1.011 0.89
179_V 183_I 1.01 0.89
229_D 232_M 1.004 0.89
176_K 244_S 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ew2A20.97361000.394Contact Map0.798
1ks9A10.96041000.404Contact Map0.827
3ghyA20.97691000.426Contact Map0.728
3egoA20.95381000.428Contact Map0.768
3hn2A40.9671000.433Contact Map0.759
2qytA10.95711000.434Contact Map0.749
3i83A20.99011000.435Contact Map0.75
3hwrA20.94721000.435Contact Map0.802
3g17A80.94391000.451Contact Map0.759
3c7aA10.98681000.476Contact Map0.578
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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