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OPENSEQ.org
OMPA - Outer membrane protein A
UniProt: P0A910 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10669
Length: 346 (337)
Sequences: 734
Seq/Len: 2.18
OMPA
Paralog alert: 0.16 [within 20: 0.03] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
275_E 279_Q 4.415 1.00
271_Q 275_E 4.209 1.00
226_N 269_Y 3.728 1.00
290_I 294_K 3.665 1.00
152_I 158_T 3.398 1.00
260_Y 304_N 3.054 1.00
238_L 284_Y 2.834 1.00
156_I 189_Y 2.715 1.00
272_G 276_R 2.612 1.00
225_F 264_I 2.58 1.00
258_L 300_M 2.493 1.00
226_N 276_R 2.452 1.00
283_D 287_S 2.415 1.00
33_K 59_G 2.314 1.00
29_Y 63_G 2.277 1.00
230_L 284_Y 2.192 1.00
224_N 227_K 2.169 1.00
255_V 295_I 2.13 1.00
115_Y 147_G 2.102 0.99
291_P 294_K 2.051 0.99
66_V 72_F 2.042 0.99
309_N 314_V 2.024 0.99
224_N 231_K 2 0.99
204_P 208_P 1.963 0.99
279_Q 283_D 1.943 0.99
311_C 314_V 1.914 0.99
307_T 314_V 1.9 0.99
269_Y 273_L 1.885 0.99
111_D 150_Y 1.875 0.99
279_Q 297_A 1.763 0.98
269_Y 272_G 1.761 0.98
257_V 295_I 1.712 0.97
239_D 243_S 1.678 0.96
31_G 61_F 1.671 0.96
267_D 302_E 1.654 0.96
153_T 156_I 1.639 0.96
243_S 247_N 1.603 0.95
271_Q 303_S 1.582 0.95
245_L 294_K 1.501 0.92
57_G 184_S 1.487 0.92
307_T 311_C 1.472 0.91
73_E 161_E 1.465 0.91
269_Y 276_R 1.463 0.91
263_R 302_E 1.432 0.90
274_S 299_G 1.417 0.89
271_Q 299_G 1.416 0.89
278_A 299_G 1.393 0.88
238_L 244_Q 1.392 0.88
239_D 288_K 1.39 0.88
320_L 323_C 1.384 0.88
311_C 323_C 1.381 0.87
228_A 276_R 1.368 0.87
269_Y 302_E 1.365 0.87
6_I 16_A 1.353 0.86
101_T 143_V 1.35 0.86
149_E 159_R 1.35 0.86
164_W 181_G 1.343 0.85
160_L 185_L 1.342 0.85
267_D 303_S 1.336 0.85
117_R 145_A 1.335 0.85
239_D 284_Y 1.318 0.84
275_E 297_A 1.283 0.82
308_G 314_V 1.278 0.81
242_Y 285_L 1.265 0.80
30_T 62_G 1.265 0.80
245_L 290_I 1.263 0.80
56_L 66_V 1.254 0.80
256_V 298_R 1.24 0.78
234_G 237_A 1.24 0.78
318_A 322_D 1.236 0.78
149_E 163_Q 1.232 0.78
230_L 280_S 1.226 0.77
320_L 324_L 1.225 0.77
282_V 297_A 1.222 0.77
66_V 208_P 1.218 0.77
257_V 278_A 1.217 0.77
32_A 189_Y 1.207 0.76
143_V 165_T 1.197 0.75
305_P 309_N 1.194 0.75
268_A 272_G 1.191 0.74
35_G 57_G 1.177 0.73
308_G 311_C 1.167 0.72
63_G 73_E 1.156 0.71
199_V 202_P 1.152 0.71
29_Y 73_E 1.141 0.70
202_P 205_A 1.138 0.70
256_V 296_S 1.132 0.69
162_Y 181_G 1.131 0.69
230_L 238_L 1.128 0.69
260_Y 303_S 1.127 0.68
311_C 324_L 1.125 0.68
320_L 328_R 1.123 0.68
103_K 149_E 1.123 0.68
286_I 299_G 1.116 0.67
117_R 161_E 1.109 0.67
227_K 276_R 1.106 0.66
295_I 330_V 1.103 0.66
123_W 139_G 1.1 0.66
282_V 286_I 1.098 0.66
275_E 298_R 1.095 0.65
112_L 150_Y 1.095 0.65
319_A 328_R 1.093 0.65
108_I 191_F 1.093 0.65
242_Y 246_S 1.092 0.65
311_C 315_K 1.091 0.65
112_L 148_V 1.087 0.64
225_F 262_D 1.087 0.64
185_L 227_K 1.085 0.64
73_E 159_R 1.079 0.64
65_Q 116_T 1.074 0.63
263_R 311_C 1.07 0.63
258_L 298_R 1.069 0.63
120_G 140_V 1.068 0.62
318_A 327_D 1.064 0.62
275_E 283_D 1.064 0.62
117_R 143_V 1.063 0.62
217_L 221_V 1.061 0.62
321_I 324_L 1.057 0.61
228_A 286_I 1.057 0.61
319_A 322_D 1.056 0.61
92_A 126_D 1.055 0.61
263_R 314_V 1.052 0.61
271_Q 279_Q 1.052 0.61
85_K 152_I 1.049 0.60
61_F 65_Q 1.047 0.60
206_P 212_T 1.044 0.60
76_Y 149_E 1.043 0.60
311_C 320_L 1.039 0.59
151_A 191_F 1.034 0.59
120_G 144_F 1.034 0.59
226_N 241_L 1.033 0.59
17_T 20_Q 1.032 0.58
14_G 18_V 1.027 0.58
266_S 269_Y 1.026 0.58
27_T 64_Y 1.017 0.57
145_A 161_E 1.013 0.56
254_S 294_K 1.007 0.56
10_V 14_G 1.005 0.55
245_L 255_V 1.001 0.55
251_K 337_I 1.001 0.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3nb3A30.99131000.291Contact Map0.662
4erhA20.4221000.611Contact Map0.569
1r1mA10.40461000.621Contact Map0.481
4b5cA30.38731000.651Contact Map0.667
2kgwA10.36991000.651Contact Map0.509
3td3A80.35261000.663Contact Map0.673
2hqsH40.33531000.666Contact Map0.675
2aizP10.37571000.667Contact Map0.508
3ldtA10.47111000.672Contact Map0.346
3cypB40.34391000.673Contact Map0.532
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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