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OPENSEQ.org
TIG - Trigger factor
UniProt: P0A850 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11003
Length: 432 (430)
Sequences: 1664
Seq/Len: 3.87
TIG
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
210_E 236_N 4.155 1.00
205_H 211_F 3.924 1.00
214_D 230_A 3.685 1.00
142_D 145_R 3.6 1.00
158_V 189_M 3.593 1.00
124_E 416_K 3.411 1.00
184_D 238_K 3.225 1.00
205_H 237_L 2.948 1.00
74_N 105_Y 2.851 1.00
207_A 240_V 2.837 1.00
212_T 232_K 2.756 1.00
77_D 81_K 2.753 1.00
172_V 229_K 2.66 1.00
293_G 296_K 2.66 1.00
40_R 46_K 2.619 1.00
153_E 239_K 2.557 1.00
98_K 101_E 2.525 1.00
152_K 244_E 2.52 1.00
169_T 234_A 2.494 1.00
275_E 279_K 2.49 1.00
169_T 176_E 2.435 1.00
157_A 206_K 2.428 1.00
116_E 299_D 2.425 1.00
353_E 356_R 2.418 1.00
138_D 142_D 2.407 1.00
292_E 343_R 2.39 1.00
138_D 267_R 2.359 1.00
159_E 242_E 2.359 1.00
127_K 419_E 2.326 1.00
268_A 272_K 2.321 1.00
353_E 357_T 2.291 1.00
169_T 181_K 2.288 1.00
172_V 231_A 2.271 1.00
135_A 138_D 2.241 1.00
135_A 139_G 2.199 1.00
214_D 232_K 2.198 1.00
210_E 234_A 2.176 1.00
304_A 308_D 2.155 1.00
171_S 234_A 2.146 1.00
142_D 146_K 2.104 1.00
134_D 271_R 2.07 1.00
18_T 102_D 2.03 1.00
342_K 346_V 1.969 1.00
121_E 414_K 1.968 1.00
224_E 227_K 1.963 1.00
167_D 238_K 1.962 1.00
264_E 268_A 1.961 1.00
206_K 209_E 1.939 1.00
312_D 334_R 1.936 1.00
271_R 275_E 1.918 1.00
73_R 77_D 1.916 1.00
136_D 278_L 1.903 1.00
165_T 238_K 1.87 1.00
292_E 296_K 1.84 1.00
363_D 366_R 1.81 0.99
133_T 136_D 1.795 0.99
338_E 342_K 1.788 0.99
160_A 200_D 1.787 0.99
332_L 335_E 1.786 0.99
25_E 29_K 1.774 0.99
126_E 420_K 1.757 0.99
250_A 253_I 1.729 0.99
158_V 164_V 1.728 0.99
12_G 110_E 1.712 0.99
23_S 26_T 1.68 0.99
165_T 239_K 1.669 0.99
145_R 245_L 1.663 0.99
212_T 234_A 1.659 0.99
140_M 143_T 1.628 0.99
216_T 230_A 1.626 0.99
120_L 358_N 1.62 0.99
285_R 289_Q 1.568 0.98
269_E 272_K 1.561 0.98
265_G 268_A 1.554 0.98
160_A 203_K 1.553 0.98
202_I 205_H 1.54 0.98
253_I 263_V 1.537 0.98
365_E 368_K 1.532 0.98
146_K 243_R 1.527 0.98
156_G 242_E 1.526 0.98
410_A 414_K 1.521 0.98
77_D 80_I 1.511 0.98
272_K 276_R 1.51 0.98
145_R 248_L 1.509 0.98
131_E 421_E 1.483 0.97
14_R 106_S 1.461 0.97
358_N 410_A 1.439 0.96
171_S 176_E 1.434 0.96
272_K 275_E 1.428 0.96
207_A 239_K 1.412 0.96
141_L 263_V 1.409 0.96
260_D 269_E 1.406 0.96
371_I 375_A 1.405 0.96
96_E 104_T 1.401 0.96
250_A 262_S 1.395 0.96
118_Q 298_N 1.388 0.95
253_I 266_L 1.385 0.95
166_I 235_I 1.383 0.95
190_G 199_E 1.383 0.95
155_D 159_E 1.374 0.95
205_H 213_I 1.372 0.95
264_E 267_R 1.369 0.95
310_E 344_R 1.358 0.95
263_V 267_R 1.355 0.95
126_E 289_Q 1.343 0.94
134_D 137_V 1.338 0.94
110_E 305_A 1.336 0.94
119_G 122_A 1.334 0.94
288_S 292_E 1.331 0.94
124_E 293_G 1.328 0.94
41_I 49_V 1.327 0.94
158_V 240_V 1.319 0.93
134_D 138_D 1.314 0.93
211_F 237_L 1.297 0.93
19_I 105_Y 1.292 0.92
161_E 188_A 1.291 0.92
261_G 265_G 1.289 0.92
302_V 307_I 1.283 0.92
335_E 338_E 1.258 0.91
52_N 55_A 1.257 0.91
80_I 83_K 1.253 0.91
18_T 104_T 1.252 0.91
383_E 386_E 1.247 0.91
165_T 241_E 1.247 0.91
304_A 338_E 1.244 0.90
366_R 406_Q 1.243 0.90
144_L 266_L 1.238 0.90
151_W 163_R 1.235 0.90
158_V 237_L 1.23 0.90
279_K 283_R 1.225 0.90
165_T 186_V 1.219 0.89
300_I 346_V 1.217 0.89
176_E 181_K 1.216 0.89
79_I 86_P 1.209 0.89
293_G 297_A 1.198 0.88
369_G 372_E 1.197 0.88
15_V 78_A 1.195 0.88
152_K 242_E 1.193 0.88
126_E 418_T 1.193 0.88
386_E 390_K 1.192 0.88
201_G 213_I 1.183 0.87
16_T 106_S 1.182 0.87
158_V 203_K 1.179 0.87
140_M 277_E 1.176 0.87
49_V 53_I 1.174 0.87
423_T 426_E 1.167 0.86
363_D 367_V 1.163 0.86
35_V 39_V 1.161 0.86
39_V 54_V 1.154 0.85
276_R 280_S 1.15 0.85
139_G 143_T 1.149 0.85
16_T 104_T 1.14 0.85
370_L 374_M 1.14 0.85
164_V 202_I 1.139 0.84
85_N 112_Y 1.137 0.84
17_I 105_Y 1.137 0.84
75_F 109_F 1.137 0.84
202_I 235_I 1.136 0.84
177_F 180_G 1.133 0.84
368_K 372_E 1.127 0.84
6_E 14_R 1.127 0.84
124_E 418_T 1.126 0.84
163_R 241_E 1.119 0.83
132_V 137_V 1.118 0.83
298_N 350_L 1.115 0.83
22_D 25_E 1.114 0.83
312_D 316_R 1.112 0.82
171_S 232_K 1.11 0.82
139_G 142_D 1.108 0.82
33_V 36_A 1.108 0.82
32_L 62_V 1.103 0.82
380_D 383_E 1.098 0.81
116_E 357_T 1.098 0.81
54_V 58_Y 1.09 0.81
67_L 103_F 1.089 0.81
10_G 301_D 1.086 0.80
268_A 275_E 1.084 0.80
202_I 211_F 1.082 0.80
51_M 55_A 1.082 0.80
215_V 233_F 1.077 0.80
262_S 265_G 1.076 0.80
156_G 162_D 1.071 0.79
362_A 402_A 1.064 0.78
148_Q 255_R 1.064 0.78
294_L 350_L 1.063 0.78
115_V 353_E 1.061 0.78
355_I 407_A 1.06 0.78
166_I 237_L 1.058 0.78
368_K 371_I 1.05 0.77
29_K 33_V 1.046 0.77
12_G 108_E 1.041 0.76
185_F 193_R 1.04 0.76
46_K 49_V 1.038 0.76
168_F 221_Y 1.036 0.76
26_T 30_S 1.032 0.75
164_V 237_L 1.026 0.75
329_A 332_L 1.025 0.75
167_D 236_N 1.024 0.75
129_I 419_E 1.022 0.74
141_L 253_I 1.02 0.74
367_V 371_I 1.018 0.74
205_H 209_E 1.015 0.74
115_V 350_L 1.014 0.74
164_V 240_V 1.012 0.73
213_I 235_I 1.012 0.73
170_G 180_G 1.007 0.73
257_G 262_S 1.006 0.73
141_L 145_R 1.005 0.73
308_D 334_R 1.004 0.73
131_E 134_D 1.003 0.73
149_A 243_R 1.003 0.73
311_I 338_E 1.003 0.73
316_R 320_Q 1.001 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1w26A211000.072Contact Map0.751
1t11A20.90051000.138Contact Map0.628
3gtyX10.96061000.15Contact Map0.635
1p9yA20.27311000.697Contact Map0.784
1zxjA40.47451000.699Contact Map0.608
2d3o110.25691000.717Contact Map0.334
2nscA10.25231000.731Contact Map0.364
2nsaA10.379699.90.748Contact Map0.536
1hxvA10.259399.70.82Contact Map0.694
3prbA20.377399.70.827Contact Map0.837
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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