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OPENSEQ.org
PEPE - Peptidase E
UniProt: P0A7C6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11920
Length: 229 (229)
Sequences: 488
Seq/Len: 2.13
PEPE
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
110_V 149_L 2.357 1.00
109_V 114_A 2.322 1.00
95_K 99_E 2.305 1.00
215_K 218_E 2.283 1.00
35_V 76_A 2.194 1.00
53_T 57_L 2.181 1.00
75_A 79_N 2.145 1.00
6_L 20_A 2.08 0.99
33_S 63_S 1.946 0.99
94_L 146_A 1.937 0.99
35_V 77_I 1.865 0.98
94_L 130_I 1.856 0.98
188_I 213_V 1.818 0.98
130_I 146_A 1.771 0.98
83_V 114_A 1.732 0.97
50_T 66_G 1.684 0.96
124_N 133_T 1.654 0.96
36_F 49_Y 1.645 0.96
106_I 110_V 1.56 0.94
5_L 126_A 1.557 0.94
40_A 93_L 1.554 0.94
24_I 117_I 1.541 0.93
32_R 81_E 1.539 0.93
107_T 111_K 1.537 0.93
98_R 142_Q 1.516 0.92
160_N 191_P 1.511 0.92
10_T 13_G 1.488 0.92
33_S 81_E 1.465 0.91
194_N 211_T 1.438 0.90
219_E 227_H 1.39 0.87
36_F 86_G 1.385 0.87
133_T 171_R 1.349 0.85
213_V 221_V 1.347 0.85
37_I 67_I 1.346 0.85
150_F 198_V 1.339 0.85
140_D 143_G 1.32 0.84
55_A 196_I 1.317 0.83
34_A 84_I 1.316 0.83
198_V 203_A 1.315 0.83
175_I 189_G 1.312 0.83
85_V 116_Y 1.31 0.83
123_A 154_I 1.301 0.82
65_T 76_A 1.299 0.82
31_R 62_V 1.288 0.81
35_V 67_I 1.287 0.81
2_E 199_S 1.259 0.79
57_L 93_L 1.258 0.79
217_G 226_G 1.233 0.77
77_I 109_V 1.233 0.77
215_K 221_V 1.228 0.77
97_C 125_L 1.218 0.76
36_F 53_T 1.187 0.73
195_W 206_G 1.185 0.73
9_S 12_P 1.183 0.73
216_A 222_P 1.156 0.71
16_W 19_H 1.148 0.70
5_L 8_N 1.147 0.70
221_V 225_A 1.145 0.70
3_L 7_S 1.141 0.69
38_P 89_N 1.139 0.69
34_A 62_V 1.138 0.69
223_L 227_H 1.137 0.69
95_K 139_V 1.135 0.69
106_I 149_L 1.134 0.68
34_A 106_I 1.131 0.68
155_N 171_R 1.114 0.67
35_V 80_A 1.111 0.66
218_E 221_V 1.109 0.66
91_F 137_P 1.108 0.66
212_Y 220_A 1.106 0.66
61_G 217_G 1.103 0.65
125_L 130_I 1.097 0.65
67_I 76_A 1.097 0.65
164_E 216_A 1.094 0.64
190_L 196_I 1.088 0.64
196_I 203_A 1.085 0.64
37_I 105_P 1.083 0.63
110_V 126_A 1.077 0.63
36_F 89_N 1.076 0.63
53_T 86_G 1.074 0.62
96_Q 99_E 1.059 0.61
79_N 107_T 1.058 0.61
49_Y 53_T 1.051 0.60
188_I 205_L 1.05 0.60
210_T 220_A 1.048 0.60
67_I 85_V 1.045 0.59
138_I 141_P 1.037 0.58
9_S 36_F 1.034 0.58
224_E 227_H 1.034 0.58
147_L 151_P 1.033 0.58
210_T 224_E 1.029 0.57
119_W 132_T 1.027 0.57
39_F 103_L 1.026 0.57
107_T 110_V 1.026 0.57
31_R 81_E 1.026 0.57
132_T 192_E 1.024 0.57
13_G 226_G 1.024 0.57
132_T 174_R 1.02 0.56
28_L 82_I 1.02 0.56
127_C 153_Q 1.018 0.56
94_L 141_P 1.007 0.55
164_E 224_E 1.005 0.55
220_A 227_H 1.005 0.55
126_A 149_L 1.001 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1fy2A111000.401Contact Map0.589
3l4eA10.86031000.518Contact Map0.571
3en0A30.93451000.528Contact Map0.585
1ka9H10.768697.30.88Contact Map0.481
2nv0A20.7555970.887Contact Map0.535
1jvnA20.759896.90.888Contact Map0.53
2issD30.838496.80.889Contact Map0.655
1gpwB30.746796.60.892Contact Map0.59
1q7rA10.847296.30.895Contact Map0.498
2ywdA10.759895.80.899Contact Map0.469
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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