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OPENSEQ.org

RSMG - Ribosomal RNA small subunit methyltransferase G
UniProt: P0A6U5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10376
Length: 207 (203)
Sequences: 1777
Seq/Len: 8.75

RSMG
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
98_L 101_R 3.485 1.00
102_V 119_P 2.82 1.00
80_G 94_L 2.579 1.00
70_I 136_V 2.576 1.00
183_E 203_K 2.531 1.00
109_Q 117_I 2.489 1.00
93_T 120_V 2.374 1.00
70_I 95_L 2.318 1.00
58_I 86_V 2.303 1.00
122_S 126_E 2.224 1.00
72_V 151_C 2.179 1.00
84_S 116_N 2.164 1.00
91_H 118_E 2.089 1.00
34_W 37_A 2.026 1.00
134_D 156_G 1.999 1.00
96_D 102_V 1.939 1.00
155_P 159_G 1.91 1.00
17_T 20_Q 1.892 1.00
109_Q 119_P 1.883 1.00
26_A 111_E 1.842 1.00
97_S 123_R 1.81 1.00
19_H 23_Q 1.756 1.00
26_A 29_N 1.744 1.00
61_A 87_R 1.724 1.00
30_M 111_E 1.718 1.00
30_M 108_V 1.687 1.00
68_R 91_H 1.684 1.00
83_L 92_F 1.672 1.00
28_V 49_M 1.655 1.00
34_W 38_Y 1.642 1.00
45_D 48_E 1.616 1.00
138_S 147_M 1.597 1.00
165_K 172_E 1.583 1.00
27_Y 81_I 1.567 1.00
81_I 117_I 1.56 1.00
60_V 164_L 1.556 1.00
25_I 29_N 1.549 1.00
95_L 127_F 1.545 1.00
20_Q 85_I 1.527 1.00
93_T 133_F 1.523 1.00
69_F 92_F 1.521 1.00
151_C 161_F 1.508 1.00
170_E 174_A 1.466 1.00
106_R 110_H 1.454 0.99
60_V 137_I 1.434 0.99
74_T 94_L 1.425 0.99
8_L 55_L 1.422 0.99
107_Q 111_E 1.421 0.99
30_M 107_Q 1.419 0.99
102_V 121_Q 1.4 0.99
96_D 119_P 1.39 0.99
142_A 146_D 1.385 0.99
20_Q 23_Q 1.384 0.99
8_L 12_A 1.373 0.99
143_S 146_D 1.371 0.99
106_R 119_P 1.357 0.99
69_F 137_I 1.352 0.99
54_I 78_L 1.34 0.99
91_H 116_N 1.319 0.99
156_G 159_G 1.308 0.99
28_V 54_I 1.301 0.99
143_S 175_L 1.295 0.99
70_I 133_F 1.289 0.98
6_S 21_K 1.279 0.98
16_L 86_V 1.267 0.98
94_L 105_L 1.257 0.98
185_V 200_V 1.251 0.98
94_L 117_I 1.247 0.98
28_V 32_H 1.241 0.98
87_R 90_A 1.227 0.98
74_T 80_G 1.225 0.98
70_I 154_L 1.22 0.98
76_P 104_F 1.219 0.98
16_L 20_Q 1.218 0.98
27_Y 78_L 1.215 0.98
104_F 108_V 1.215 0.98
144_L 163_A 1.184 0.97
136_V 155_P 1.181 0.97
84_S 117_I 1.181 0.97
27_Y 105_L 1.173 0.97
169_P 198_H 1.173 0.97
142_A 147_M 1.167 0.97
74_T 102_V 1.166 0.97
29_N 32_H 1.162 0.97
59_V 188_L 1.161 0.97
34_W 107_Q 1.151 0.96
107_Q 110_H 1.148 0.96
76_P 101_R 1.108 0.95
43_V 52_R 1.07 0.94
186_V 201_V 1.066 0.94
93_T 118_E 1.066 0.94
33_K 36_K 1.062 0.93
24_L 82_P 1.062 0.93
30_M 34_W 1.061 0.93
96_D 105_L 1.059 0.93
63_Y 162_Y 1.058 0.93
96_D 121_Q 1.058 0.93
22_N 26_A 1.049 0.93
102_V 106_R 1.043 0.93
106_R 109_Q 1.033 0.92
19_H 22_N 1.028 0.92
72_V 95_L 1.027 0.92
31_L 41_T 1.022 0.92
9_L 16_L 1.009 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xdzA1199.90.578Contact Map0.794
1jsxA1199.90.583Contact Map0.78
3g89A20.995299.90.595Contact Map0.795
2b3tA10.956599.60.735Contact Map0.65
3hp7A10.980799.60.739Contact Map0.532
3ocjA10.97199.50.758Contact Map0.492
2ozvA20.845499.30.778Contact Map0.797
1nv8A20.922799.30.779Contact Map0.466
4aukA20.946999.20.789Contact Map0.516
3bwcA2199.20.792Contact Map0.54

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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