OPENSEQ.org - FTSB - ECOLI GREMLIN

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FTSB - Cell division protein FtsB

UniProt:	P0A6S5	Sequence MGKLTLLLLAILVWLQYSLWFGKNGIHDYTRVNDDVAAQQATNAKLKARNDQLFAEIDDLNGGQEALEERARNELSMTRPGETFYRLVPDASKRAQSAGQNNR	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG13111
Length:	103 (93)
Sequences:	343
Seq/Len:	3.69

FTSB
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
24_N	57_I	2.647	1.00
59_D	63_G	2.413	1.00
46_L	49_R	2.374	1.00
16_Q	20_W	2.191	1.00
24_N	29_Y	1.751	0.99
18_S	26_I	1.707	0.99
10_A	14_W	1.629	0.99
18_S	23_K	1.629	0.99
4_L	37_A	1.594	0.98
48_A	51_D	1.566	0.98
21_F	27_H	1.536	0.98
39_Q	43_N	1.508	0.97
18_S	25_G	1.484	0.97
70_R	74_E	1.474	0.97
68_E	77_M	1.456	0.96
36_V	52_Q	1.455	0.96
22_G	25_G	1.426	0.96
56_E	77_M	1.338	0.93
70_R	84_F	1.281	0.91
74_E	86_R	1.273	0.91
16_Q	70_R	1.258	0.90
68_E	79_R	1.249	0.90
57_I	86_R	1.244	0.90
66_A	84_F	1.235	0.89
47_K	51_D	1.23	0.89
70_R	77_M	1.208	0.88
20_W	71_A	1.193	0.87
25_G	85_Y	1.187	0.87
17_Y	70_R	1.18	0.86
28_D	87_L	1.172	0.86
7_L	13_V	1.156	0.85
22_G	74_E	1.141	0.84
73_N	77_M	1.126	0.82
29_Y	57_I	1.071	0.78
8_L	19_L	1.064	0.77
23_K	32_V	1.062	0.77
33_N	37_A	1.033	0.74
47_K	73_N	1.033	0.74
59_D	74_E	1.027	0.74
36_V	39_Q	1.027	0.74
13_V	81_G	1.015	0.72
33_N	62_G	1.012	0.72
16_Q	71_A	1	0.71

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
4iffA	4	0.5922	97.8	0.762	Contact Map	0.592
4dznA	3	0.301	76.6	0.876	Contact Map	0.559
1kd8A	3	0.3398	55	0.892	Contact Map	0.755
4etpA	1	0.7282	46.8	0.897	Contact Map	0.284
1a93B	1	0.3107	40.8	0.901	Contact Map	0.584
2yy0A	4	0.5146	36	0.904	Contact Map	0.723
2oxjA	3	0.233	35.5	0.904	Contact Map	0.843
3m48A	1	0.2913	33.7	0.906	Contact Map	0.781
2hy6A	7	0.3301	32.2	0.906	Contact Map	0.714
3c3gA	1	0.1942	28.6	0.909	Contact Map	0.84

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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