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OPENSEQ.org
DAPF - Diaminopimelate epimerase
UniProt: P0A6K1 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10209
Length: 274 (273)
Sequences: 1710
Seq/Len: 6.26
DAPF
Paralog alert: 0.03 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
201_H 241_E 3.865 1.00
46_L 76_G 3.723 1.00
199_R 235_A 3.714 1.00
61_R 69_E 3.331 1.00
71_A 187_E 3.273 1.00
225_V 238_V 3.004 1.00
198_K 201_H 2.939 1.00
38_L 215_Q 2.875 1.00
226_A 258_L 2.867 1.00
94_D 107_T 2.769 1.00
241_E 246_R 2.756 1.00
3_F 270_G 2.742 1.00
171_A 174_T 2.626 1.00
117_N 257_P 2.5 1.00
179_L 191_I 2.481 1.00
237_E 250_A 2.419 1.00
249_I 260_M 2.201 1.00
228_G 234_L 2.096 1.00
122_N 127_A 2.063 1.00
59_H 98_S 2.054 1.00
202_I 240_V 2.044 1.00
82_R 86_L 2.004 1.00
194_M 224_A 1.96 1.00
124_E 127_A 1.938 1.00
2_Q 271_F 1.938 1.00
202_I 224_A 1.928 1.00
266_H 269_D 1.899 1.00
155_M 258_L 1.891 1.00
180_E 188_R 1.882 1.00
12_D 36_R 1.868 1.00
9_L 216_A 1.855 1.00
115_R 259_Y 1.847 1.00
48_V 80_F 1.814 1.00
34_A 42_F 1.786 1.00
205_R 213_E 1.785 1.00
192_G 220_G 1.773 1.00
201_H 239_R 1.744 1.00
166_D 169_T 1.738 1.00
115_R 261_T 1.737 1.00
181_S 188_R 1.728 1.00
239_R 246_R 1.705 1.00
33_L 272_I 1.623 1.00
96_R 105_V 1.616 1.00
18_A 49_E 1.603 1.00
7_H 265_V 1.602 1.00
225_V 240_V 1.587 0.99
195_Q 203_R 1.573 0.99
115_R 250_A 1.572 0.99
151_G 227_V 1.53 0.99
16_V 45_L 1.51 0.99
203_R 241_E 1.487 0.99
107_T 115_R 1.479 0.99
25_F 30_I 1.478 0.99
63_F 69_E 1.464 0.99
42_F 45_L 1.445 0.99
77_A 97_V 1.433 0.99
194_M 202_I 1.433 0.99
73_C 217_C 1.408 0.98
163_Q 228_G 1.406 0.98
168_D 203_R 1.405 0.98
192_G 204_L 1.405 0.98
57_D 92_K 1.396 0.98
87_K 269_D 1.366 0.98
71_A 101_N 1.36 0.98
150_C 160_C 1.355 0.98
224_A 240_V 1.353 0.98
162_I 191_I 1.347 0.98
192_G 206_V 1.344 0.98
69_E 100_A 1.328 0.98
40_V 272_I 1.295 0.97
222_C 258_L 1.293 0.97
14_M 268_Y 1.29 0.97
51_P 98_S 1.289 0.97
12_D 41_G 1.286 0.97
14_M 33_L 1.284 0.97
120_E 256_H 1.281 0.97
76_G 81_A 1.281 0.97
239_R 248_D 1.277 0.97
123_F 230_Q 1.271 0.97
7_H 38_L 1.267 0.96
9_L 242_L 1.266 0.96
58_F 90_T 1.264 0.96
35_D 39_G 1.257 0.96
47_V 63_F 1.254 0.96
13_F 42_F 1.251 0.96
49_E 59_H 1.249 0.96
48_V 84_V 1.23 0.96
80_F 97_V 1.229 0.96
163_Q 194_M 1.228 0.96
99_T 102_G 1.224 0.95
217_C 220_G 1.22 0.95
82_R 264_A 1.214 0.95
2_Q 269_D 1.206 0.95
204_L 224_A 1.205 0.95
58_F 84_V 1.19 0.94
166_D 195_Q 1.189 0.94
177_P 207_Y 1.182 0.94
237_E 248_D 1.176 0.94
26_S 29_L 1.176 0.94
36_R 41_G 1.176 0.94
144_A 178_V 1.171 0.94
56_L 103_R 1.171 0.94
30_I 45_L 1.169 0.94
202_I 228_G 1.165 0.94
14_M 40_V 1.161 0.93
213_E 243_P 1.157 0.93
163_Q 227_V 1.156 0.93
94_D 105_V 1.134 0.92
121_P 251_W 1.129 0.92
225_V 229_I 1.126 0.92
58_F 89_L 1.126 0.92
167_V 195_Q 1.124 0.92
72_Q 219_S 1.123 0.92
252_K 255_G 1.122 0.92
118_M 222_C 1.112 0.91
18_A 47_V 1.112 0.91
181_S 207_Y 1.105 0.91
229_I 236_E 1.104 0.91
204_L 221_A 1.1 0.91
33_L 42_F 1.099 0.91
153_V 227_V 1.083 0.90
197_V 203_R 1.083 0.90
34_A 65_A 1.08 0.90
49_E 61_R 1.073 0.89
8_G 79_C 1.07 0.89
120_E 257_P 1.067 0.89
157_N 192_G 1.06 0.89
148_I 162_I 1.058 0.88
34_A 44_Q 1.056 0.88
236_E 253_G 1.054 0.88
157_N 206_V 1.052 0.88
56_L 98_S 1.041 0.87
35_D 38_L 1.037 0.87
65_A 211_A 1.034 0.87
163_Q 233_L 1.033 0.87
180_E 207_Y 1.033 0.87
123_F 226_A 1.005 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fveA10.94531000.317Contact Map0.654
2otnA20.98541000.317Contact Map0.813
2gkeA10.99641000.323Contact Map0.816
3ejxA60.99271000.328Contact Map0.854
3ednA20.94891000.451Contact Map0.516
1ym5A10.95621000.471Contact Map0.522
4jbdA10.95261000.481Contact Map0.313
3g7kA40.99271000.487Contact Map0.498
1xubA10.93431000.496Contact Map0.506
4dunA10.90151000.498Contact Map0.476
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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