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CYSZ - Protein CysZ
UniProt: P0A6J3 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10003
Length: 253 (243)
Sequences: 333
Seq/Len: 1.37

CYSZ
Paralog alert: 0.00 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
138_R 189_D 2.005 0.98
98_W 140_W 1.955 0.97
139_E 142_K 1.862 0.96
19_G 236_G 1.841 0.96
104_N 230_M 1.747 0.94
150_A 171_W 1.718 0.93
152_V 155_I 1.688 0.92
138_R 182_Q 1.617 0.90
41_L 44_G 1.616 0.90
153_L 174_F 1.573 0.88
222_I 225_L 1.548 0.87
66_P 69_L 1.526 0.86
112_E 191_H 1.505 0.85
27_G 30_R 1.501 0.84
165_T 168_P 1.498 0.84
12_G 15_Y 1.494 0.84
179_L 199_R 1.48 0.83
138_R 148_P 1.476 0.83
188_F 201_A 1.463 0.82
12_G 211_Q 1.461 0.82
148_P 189_D 1.452 0.82
115_L 239_A 1.414 0.79
97_N 183_Y 1.41 0.79
137_K 141_Q 1.409 0.79
148_P 182_Q 1.408 0.79
139_E 195_F 1.397 0.78
206_K 210_M 1.391 0.78
212_F 236_G 1.362 0.75
23_V 176_A 1.359 0.75
149_R 174_F 1.343 0.74
137_K 209_N 1.343 0.74
108_A 201_A 1.34 0.74
26_P 225_L 1.339 0.74
25_Q 114_R 1.31 0.71
34_L 38_V 1.309 0.71
101_A 225_L 1.292 0.70
68_W 86_L 1.287 0.69
31_F 107_L 1.271 0.68
134_R 189_D 1.267 0.68
148_P 152_V 1.263 0.67
69_L 72_L 1.256 0.67
23_V 41_L 1.252 0.66
151_I 155_I 1.231 0.64
116_T 122_D 1.231 0.64
67_D 193_V 1.23 0.64
108_A 199_R 1.228 0.64
163_G 188_F 1.226 0.64
138_R 198_M 1.221 0.64
142_K 185_D 1.216 0.63
160_P 163_G 1.214 0.63
142_K 195_F 1.21 0.62
68_W 228_F 1.201 0.62
131_D 134_R 1.201 0.62
182_Q 198_M 1.192 0.61
181_I 198_M 1.19 0.61
31_F 230_M 1.187 0.60
38_V 87_V 1.185 0.60
164_Q 168_P 1.185 0.60
76_L 140_W 1.156 0.57
55_D 70_Q 1.155 0.57
52_T 129_M 1.152 0.57
40_I 58_I 1.143 0.56
212_F 238_T 1.141 0.56
67_D 129_M 1.138 0.55
164_Q 188_F 1.137 0.55
208_T 240_M 1.136 0.55
108_A 216_T 1.135 0.55
77_W 171_W 1.124 0.54
219_F 237_A 1.118 0.53
18_Q 21_K 1.118 0.53
86_L 187_P 1.117 0.53
48_W 162_I 1.114 0.53
98_W 144_A 1.111 0.53
189_D 241_W 1.11 0.53
218_L 228_F 1.105 0.52
24_S 244_C 1.105 0.52
182_Q 185_D 1.102 0.52
108_A 142_K 1.102 0.52
14_Y 18_Q 1.093 0.51
36_L 97_N 1.092 0.51
92_F 97_N 1.09 0.51
23_V 151_I 1.086 0.50
89_G 111_L 1.083 0.50
182_Q 189_D 1.08 0.50
100_A 104_N 1.079 0.50
39_N 139_E 1.078 0.49
166_V 170_L 1.077 0.49
26_P 29_R 1.071 0.49
173_L 200_T 1.068 0.48
179_L 203_R 1.065 0.48
154_L 157_Y 1.063 0.48
177_W 190_N 1.061 0.48
78_P 171_W 1.061 0.48
195_F 226_N 1.059 0.48
58_I 84_V 1.056 0.47
38_V 110_Q 1.053 0.47
158_F 204_T 1.052 0.47
140_W 144_A 1.047 0.46
154_L 176_A 1.039 0.46
146_Y 178_M 1.035 0.45
101_A 217_S 1.033 0.45
12_G 236_G 1.033 0.45
44_G 227_L 1.031 0.45
28_I 46_A 1.029 0.45
175_S 203_R 1.029 0.45
136_M 144_A 1.023 0.44
33_I 204_T 1.022 0.44
113_A 121_P 1.021 0.44
50_L 74_Y 1.02 0.44
131_D 172_F 1.018 0.43
140_W 194_P 1.017 0.43
15_Y 107_L 1.016 0.43
93_S 222_I 1.016 0.43
110_Q 114_R 1.014 0.43
108_A 179_L 1.012 0.43
100_A 135_I 1.012 0.43
131_D 163_G 1.008 0.42
98_W 234_V 1.007 0.42
149_R 161_G 1.004 0.42
38_V 118_A 1.001 0.42
47_F 88_F 1.001 0.42
147_L 150_A 1.001 0.42
34_L 170_L 1 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tx3A20.97631000.331Contact Map0.36
2ww9B10.2498.70.969Contact Map0.494
2qjyC60.2495.90.972Contact Map0.534
4h33A10.49413.80.974Contact Map0.528
1abzA10.15813.60.974Contact Map0.087
4ltoA40.50230.975Contact Map0.357
1q90R10.19372.70.976Contact Map0.059
1t4yA10.26482.50.976Contact Map0.099
3j08A20.44272.30.977Contact Map0.174
3zuxA10.44272.30.977Contact Map0.101

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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