OPENSEQ.org - COAD - ECOLI GREMLIN

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COAD - Phosphopantetheine adenylyltransferase

UniProt:	P0A6I6	Sequence MQKRAIYPGTFDPITNGHIDIVTRATQMFDHVILAIAASPSKKPMFTLEERVALAQQATAHLGNVEVVGFSDLMANFARNQHATVLIRGLRAVADFEYEMQLAHMNRHLMPELESVFLMPSKEWSFISSSLVKEVARHQGDVTHFLPENVHQALMAKLA	Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:	EG11190
Length:	159 (156)
Sequences:	1649
Seq/Len:	10.57

COAD
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Scaled Score	Prob
31_H	66_E	5.772	1.00
68_V	77_F	3.905	1.00
14_I	55_A	3.425	1.00
68_V	81_Q	3.102	1.00
25_A	87_I	3.017	1.00
23_T	61_H	2.805	1.00
6_I	78_A	2.771	1.00
26_T	64_N	2.7	1.00
50_E	157_K	2.351	1.00
47_T	50_E	2.226	1.00
58_A	149_N	2.049	1.00
54_L	153_A	2.021	1.00
14_I	22_V	1.991	1.00
29_F	32_V	1.984	1.00
108_H	144_H	1.952	1.00
53_A	56_Q	1.942	1.00
10_T	44_P	1.849	1.00
19_I	147_P	1.795	1.00
5_A	32_V	1.782	1.00
79_R	110_M	1.776	1.00
88_R	102_L	1.775	1.00
135_V	140_G	1.697	1.00
52_V	56_Q	1.654	1.00
151_H	155_M	1.654	1.00
86_L	113_L	1.625	1.00
152_Q	156_A	1.621	1.00
53_A	57_Q	1.616	1.00
75_A	110_M	1.593	1.00
33_I	81_Q	1.593	1.00
146_L	150_V	1.566	1.00
20_D	121_S	1.554	1.00
78_A	113_L	1.528	1.00
19_I	59_T	1.517	1.00
52_V	69_G	1.498	1.00
46_F	54_L	1.435	1.00
57_Q	60_A	1.419	1.00
24_R	114_E	1.417	1.00
32_V	87_I	1.413	1.00
76_N	79_R	1.41	1.00
35_A	70_F	1.397	0.99
59_T	62_L	1.383	0.99
10_T	37_A	1.375	0.99
77_F	81_Q	1.357	0.99
105_M	135_V	1.347	0.99
57_Q	153_A	1.346	0.99
79_R	112_E	1.341	0.99
57_Q	149_N	1.317	0.99
4_R	31_H	1.263	0.99
74_M	86_L	1.234	0.98
92_A	100_M	1.233	0.98
41_S	134_E	1.209	0.98
148_E	152_Q	1.207	0.98
105_M	131_L	1.203	0.98
36_I	52_V	1.142	0.97
16_N	147_P	1.141	0.97
90_L	96_F	1.137	0.97
58_A	147_P	1.133	0.97
28_M	118_L	1.115	0.96
48_L	69_G	1.112	0.96
143_T	151_H	1.107	0.96
153_A	156_A	1.103	0.96
6_I	77_F	1.1	0.96
92_A	101_Q	1.099	0.96
28_M	116_V	1.082	0.96
142_V	154_L	1.081	0.95
21_I	118_L	1.072	0.95
14_I	150_V	1.056	0.95
75_A	113_L	1.045	0.94
103_A	117_F	1.04	0.94
104_H	125_S	1.032	0.94
134_E	138_H	1.032	0.94
34_L	59_T	1.027	0.94
45_M	158_L	1.025	0.93
74_M	102_L	1.015	0.93
40_P	138_H	1.01	0.93
49_E	53_A	1.007	0.93

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling

HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:

Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	P(%)	HHΔ		Acc
1vlhA	6	1	100	0.496	Contact Map	0.867
3k9wA	1	1	100	0.498	Contact Map	0.781
3nbkA	4	0.9937	100	0.506	Contact Map	0.81
3nd5A	6	1	100	0.507	Contact Map	0.81
3f3mA	1	1	100	0.51	Contact Map	0.724
1od6A	1	0.9874	100	0.512	Contact Map	0.778
4f3rA	3	0.9937	100	0.515	Contact Map	0.767
1o6bA	1	1	100	0.516	Contact Map	0.728
1qjcA	2	0.9937	100	0.517	Contact Map	0.809
3nv7A	1	0.9874	100	0.521	Contact Map	0.529

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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