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OPENSEQ.org
META - Homoserine O-succinyltransferase
UniProt: P07623 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10581
Length: 309 (305)
Sequences: 605
Seq/Len: 1.98
META
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
165_S 257_P 4.021 1.00
244_A 264_F 3.952 1.00
129_E 151_I 3.606 1.00
244_A 248_F 3.488 1.00
162_E 258_D 3.16 1.00
68_Q 100_F 2.876 1.00
37_K 66_D 2.555 1.00
198_P 201_L 2.336 1.00
99_N 134_H 2.309 1.00
199_A 213_E 2.305 1.00
40_I 54_F 2.301 1.00
248_F 264_F 2.175 1.00
158_Q 198_P 2.125 0.99
39_L 103_L 2.12 0.99
189_A 220_Y 2.111 0.99
268_D 271_N 2.109 0.99
240_A 275_A 2.052 0.99
72_I 75_R 2.047 0.99
129_E 132_K 2.032 0.99
199_A 203_R 2.03 0.99
216_E 261_Y 2.011 0.99
219_A 222_F 1.986 0.99
75_R 119_A 1.914 0.98
124_I 128_L 1.883 0.98
141_V 146_Q 1.869 0.98
165_S 194_Y 1.801 0.97
37_K 98_Q 1.793 0.97
84_H 88_F 1.792 0.97
140_F 152_L 1.762 0.97
96_Q 126_Q 1.76 0.97
187_F 212_A 1.755 0.97
28_A 31_Q 1.752 0.97
196_D 201_L 1.642 0.95
146_Q 157_K 1.619 0.94
7_D 26_S 1.604 0.94
128_L 152_L 1.599 0.94
158_Q 201_L 1.592 0.94
290_N 295_Q 1.546 0.93
53_Q 239_D 1.536 0.92
220_Y 236_P 1.533 0.92
241_Q 245_Q 1.53 0.92
73_D 93_E 1.527 0.92
301_L 304_M 1.518 0.92
157_K 195_A 1.508 0.91
179_L 230_A 1.502 0.91
265_P 273_P 1.497 0.91
194_Y 257_P 1.49 0.91
122_P 125_K 1.485 0.90
39_L 70_L 1.471 0.90
183_F 283_L 1.464 0.90
116_N 150_N 1.459 0.89
125_K 151_I 1.459 0.89
174_H 209_E 1.459 0.89
280_H 284_L 1.45 0.89
170_H 217_G 1.432 0.88
165_S 256_D 1.424 0.88
140_F 148_A 1.415 0.87
110_L 144_A 1.39 0.86
188_L 276_S 1.382 0.86
54_F 141_V 1.374 0.85
199_A 210_I 1.361 0.84
160_R 164_L 1.36 0.84
46_K 49_E 1.353 0.84
266_H 271_N 1.348 0.84
183_F 280_H 1.344 0.83
165_S 168_Y 1.337 0.83
39_L 95_I 1.337 0.83
24_T 69_L 1.331 0.83
70_L 95_I 1.322 0.82
148_A 152_L 1.32 0.82
169_E 186_S 1.318 0.82
171_H 215_E 1.317 0.82
132_K 151_I 1.308 0.81
236_P 284_L 1.306 0.81
156_P 198_P 1.305 0.81
40_I 67_I 1.302 0.81
114_E 156_P 1.294 0.80
55_L 67_I 1.293 0.80
248_F 252_E 1.292 0.80
72_I 127_V 1.28 0.79
170_H 220_Y 1.279 0.79
146_Q 195_A 1.268 0.78
202_I 219_A 1.265 0.78
4_R 130_W 1.252 0.77
115_F 146_Q 1.242 0.76
164_L 168_Y 1.24 0.76
49_E 245_Q 1.238 0.76
294_Y 297_T 1.237 0.76
111_G 195_A 1.233 0.75
103_L 131_S 1.221 0.74
28_A 33_I 1.216 0.74
97_D 266_H 1.213 0.74
169_E 276_S 1.203 0.73
112_L 159_T 1.201 0.73
6_P 283_L 1.188 0.71
31_Q 34_R 1.175 0.70
131_S 140_F 1.168 0.70
111_G 157_K 1.161 0.69
177_A 292_Y 1.149 0.68
148_A 151_I 1.147 0.68
28_A 294_Y 1.145 0.67
46_K 245_Q 1.142 0.67
75_R 113_V 1.142 0.67
34_R 64_Q 1.139 0.67
12_V 16_R 1.131 0.66
170_H 191_H 1.125 0.65
178_L 296_I 1.12 0.65
168_Y 261_Y 1.119 0.65
265_P 272_T 1.112 0.64
31_Q 294_Y 1.101 0.63
300_D 303_H 1.099 0.63
254_G 257_P 1.097 0.63
140_F 144_A 1.097 0.63
103_L 127_V 1.096 0.62
5_V 167_V 1.095 0.62
189_A 236_P 1.094 0.62
216_E 262_N 1.09 0.62
261_Y 265_P 1.089 0.62
23_M 27_R 1.082 0.61
40_I 55_L 1.076 0.60
5_V 12_V 1.076 0.60
136_T 296_I 1.074 0.60
170_H 189_A 1.073 0.60
138_T 148_A 1.07 0.60
7_D 25_T 1.066 0.59
158_Q 196_D 1.065 0.59
28_A 34_R 1.063 0.59
202_I 210_I 1.06 0.59
12_V 48_I 1.058 0.58
197_F 233_T 1.057 0.58
168_Y 257_P 1.056 0.58
210_I 213_E 1.055 0.58
90_C 94_D 1.044 0.57
111_G 123_Q 1.044 0.57
152_L 229_I 1.033 0.56
208_L 222_F 1.031 0.55
46_K 242_T 1.027 0.55
248_F 251_V 1.024 0.55
31_Q 64_Q 1.022 0.54
199_A 219_A 1.017 0.54
224_S 228_R 1.015 0.54
203_R 210_I 1.01 0.53
191_H 217_G 1.005 0.53
65_V 289_L 1.004 0.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vdjA10.97411000.413Contact Map0.702
2h2wA10.97091000.425Contact Map0.655
3m3pA10.77021000.759Contact Map0.421
1o1yA10.770299.70.863Contact Map0.383
3l7nA10.747699.70.865Contact Map0.395
1qdlB10.614999.60.872Contact Map0.423
2lxnA10.605299.60.875Contact Map0.343
1wl8A10.598799.50.88Contact Map0.371
2vpiA20.692699.50.884Contact Map0.448
2a9vA40.673199.50.886Contact Map0.469
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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