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OPENSEQ.org
RSMA - Ribosomal RNA small subunit methyltransferase A
UniProt: P06992 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10523
Length: 273 (259)
Sequences: 2248
Seq/Len: 8.68
RSMA
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
247_M 251_N 3.51 1.00
247_M 256_Q 3.139 1.00
56_G 85_L 2.95 1.00
61_Q 86_T 2.939 1.00
40_A 63_T 2.599 1.00
253_S 256_Q 2.56 1.00
22_D 180_A 2.49 1.00
116_Y 189_S 2.457 1.00
256_Q 259_Q 2.4 1.00
96_N 99_E 2.391 1.00
55_V 111_F 2.373 1.00
18_N 184_P 2.27 1.00
146_N 172_P 2.22 1.00
149_V 170_V 2.185 1.00
145_V 190_A 2.181 1.00
177_P 180_A 2.147 1.00
28_S 174_L 2.116 1.00
169_N 195_V 2.066 1.00
63_T 88_Y 2.05 1.00
178_P 188_D 2.029 1.00
72_A 89_Q 2.014 1.00
252_I 256_Q 1.946 1.00
69_R 89_Q 1.903 1.00
217_A 257_Y 1.901 1.00
161_S 165_Q 1.893 1.00
142_K 175_E 1.862 1.00
175_E 190_A 1.844 1.00
168_C 194_L 1.844 1.00
213_I 261_A 1.824 1.00
162_V 254_V 1.818 1.00
162_V 214_T 1.791 1.00
224_T 227_N 1.787 1.00
173_V 193_R 1.784 1.00
54_P 57_E 1.764 1.00
46_P 64_V 1.721 1.00
169_N 197_H 1.707 1.00
39_Q 109_R 1.683 1.00
55_V 62_L 1.677 1.00
171_I 195_V 1.655 1.00
171_I 193_R 1.637 1.00
31_S 58_R 1.635 1.00
59_L 62_L 1.632 1.00
164_A 170_V 1.629 1.00
148_L 192_V 1.614 1.00
88_Y 95_F 1.592 1.00
92_A 122_L 1.582 1.00
139_M 176_V 1.574 1.00
119_S 140_L 1.574 1.00
224_T 246_A 1.555 1.00
15_F 67_L 1.549 1.00
76_Q 89_Q 1.526 1.00
148_L 164_A 1.517 1.00
124_F 163_M 1.489 1.00
148_L 170_V 1.48 1.00
92_A 97_F 1.475 1.00
123_M 140_L 1.448 0.99
197_H 201_P 1.44 0.99
205_K 262_N 1.425 0.99
36_Q 39_Q 1.417 0.99
207_V 210_L 1.417 0.99
222_R 250_E 1.408 0.99
27_D 54_P 1.403 0.99
109_R 135_D 1.401 0.99
172_P 190_A 1.4 0.99
172_P 175_E 1.38 0.99
65_I 95_F 1.378 0.99
142_K 146_N 1.365 0.99
110_V 126_L 1.357 0.99
244_D 247_M 1.344 0.99
53_E 79_P 1.329 0.99
155_K 250_E 1.325 0.99
26_I 54_P 1.312 0.99
33_I 112_G 1.311 0.99
140_L 145_V 1.307 0.99
11_A 182_T 1.305 0.99
235_V 239_T 1.302 0.99
217_A 249_A 1.299 0.99
243_I 247_M 1.286 0.98
16_G 117_N 1.284 0.98
24_F 180_A 1.275 0.98
35_P 39_Q 1.273 0.98
142_K 188_D 1.264 0.98
112_G 138_F 1.259 0.98
178_P 186_K 1.257 0.98
206_D 265_A 1.248 0.98
64_V 87_I 1.244 0.98
210_L 214_T 1.232 0.98
53_E 78_H 1.218 0.98
56_G 84_K 1.191 0.97
48_L 71_L 1.19 0.97
259_Q 262_N 1.189 0.97
35_P 41_M 1.188 0.97
236_E 239_T 1.182 0.97
176_V 191_V 1.159 0.96
135_D 193_R 1.151 0.96
153_N 251_N 1.15 0.96
107_P 134_A 1.146 0.96
72_A 76_Q 1.145 0.96
65_I 92_A 1.14 0.96
35_P 59_L 1.137 0.96
42_V 101_A 1.134 0.96
244_D 251_N 1.125 0.96
240_G 263_Y 1.124 0.96
205_K 266_E 1.123 0.95
165_Q 170_V 1.12 0.95
33_I 41_M 1.119 0.95
137_H 191_V 1.117 0.95
137_H 193_R 1.112 0.95
21_N 182_T 1.105 0.95
24_F 27_D 1.092 0.95
75_L 87_I 1.089 0.94
12_R 70_D 1.088 0.94
202_H 258_C 1.088 0.94
119_S 144_V 1.087 0.94
199_T 203_P 1.086 0.94
32_A 173_V 1.077 0.94
209_V 265_A 1.073 0.94
92_A 114_L 1.069 0.94
166_Y 210_L 1.068 0.94
219_N 228_S 1.06 0.93
228_S 249_A 1.056 0.93
216_E 249_A 1.054 0.93
125_H 129_Y 1.049 0.93
135_D 195_V 1.038 0.92
175_E 188_D 1.036 0.92
33_I 111_F 1.035 0.92
64_V 85_L 1.033 0.92
33_I 137_H 1.032 0.92
222_R 248_R 1.031 0.92
48_L 74_R 1.026 0.92
64_V 75_L 1.026 0.92
25_V 180_A 1.022 0.92
157_Y 161_S 1.018 0.91
40_A 61_Q 1.005 0.91
27_D 31_S 1.001 0.90
73_A 77_T 1.001 0.90
213_I 217_A 1 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1i4wA10.9781000.274Contact Map0.657
4gc5A10.99631000.299Contact Map0.761
4jxjA10.95241000.306Contact Map0.716
3tqsA40.92671000.322Contact Map0.766
3uzuA10.98171000.322Contact Map0.789
1qyrA20.92311000.325Contact Map0.795
3gruA10.96341000.359Contact Map0.79
3futA20.93771000.362Contact Map0.738
3ftdA10.90481000.369Contact Map0.798
1zq9A20.91941000.408Contact Map0.83
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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