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OPENSEQ.org
PYRC - Dihydroorotase
UniProt: P05020 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10806
Length: 348 (340)
Sequences: 3603
Seq/Len: 10.60
PYRC
Paralog alert: 0.46 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
291_H 294_A 3.92 1.00
319_E 341_T 3.519 1.00
229_N 233_Q 3.474 1.00
199_I 203_H 3.314 1.00
182_K 230_I 3.076 1.00
229_N 232_Q 3.059 1.00
34_S 71_H 2.928 1.00
158_I 184_A 2.889 1.00
299_N 302_Q 2.885 1.00
294_A 299_N 2.533 1.00
204_L 235_L 2.414 1.00
200_T 203_H 2.387 1.00
20_L 29_V 2.384 1.00
12_R 38_G 2.368 1.00
175_V 196_A 2.36 1.00
189_R 241_S 2.276 1.00
179_I 188_V 2.228 1.00
320_Q 345_S 2.2 1.00
89_E 92_R 2.193 1.00
182_K 234_A 2.121 1.00
129_R 132_K 2.043 1.00
323_A 326_I 2.016 1.00
7_V 347_K 1.947 1.00
322_V 342_V 1.94 1.00
228_R 231_H 1.939 1.00
324_E 338_A 1.926 1.00
319_E 343_R 1.926 1.00
288_A 291_H 1.908 1.00
207_N 229_N 1.907 1.00
247_F 303_F 1.896 1.00
39_R 74_T 1.89 1.00
130_M 137_L 1.885 1.00
7_V 315_L 1.879 1.00
318_E 345_S 1.878 1.00
58_A 62_R 1.85 1.00
91_E 129_R 1.844 1.00
61_Q 65_D 1.841 1.00
189_R 243_F 1.833 1.00
9_K 315_L 1.79 1.00
206_F 278_S 1.778 1.00
197_A 244_N 1.727 1.00
24_D 29_V 1.718 1.00
138_L 177_E 1.7 1.00
20_L 30_V 1.694 1.00
14_D 301_P 1.69 1.00
279_Y 296_C 1.676 1.00
27_K 31_P 1.672 1.00
16_W 247_F 1.669 1.00
291_H 295_F 1.653 1.00
35_E 328_L 1.653 1.00
293_E 297_S 1.649 1.00
127_L 172_L 1.634 1.00
282_V 286_M 1.631 1.00
16_W 304_Y 1.625 1.00
94_F 135_M 1.598 1.00
155_A 183_D 1.588 1.00
129_R 133_I 1.572 1.00
119_S 122_A 1.558 1.00
321_Q 341_T 1.556 1.00
181_T 184_A 1.552 1.00
279_Y 292_F 1.542 1.00
222_C 269_C 1.535 1.00
188_V 197_A 1.534 1.00
281_T 285_E 1.52 1.00
13_P 276_L 1.516 1.00
250_T 275_A 1.506 1.00
298_V 302_Q 1.504 1.00
205_M 278_S 1.502 1.00
283_F 286_M 1.476 1.00
237_E 241_S 1.471 1.00
182_K 186_D 1.471 1.00
134_G 173_K 1.468 1.00
294_A 298_V 1.466 1.00
186_D 190_D 1.449 1.00
178_H 251_D 1.437 1.00
30_V 69_A 1.428 1.00
20_L 40_A 1.427 1.00
77_M 93_G 1.415 1.00
171_A 194_R 1.414 1.00
37_Y 275_A 1.38 0.99
10_I 316_V 1.378 0.99
124_M 169_L 1.366 0.99
134_G 305_G 1.363 0.99
25_M 330_D 1.353 0.99
61_Q 64_L 1.345 0.99
140_H 178_H 1.344 0.99
91_E 132_K 1.343 0.99
284_E 287_N 1.343 0.99
318_E 347_K 1.34 0.99
208_R 228_R 1.332 0.99
207_N 232_Q 1.329 0.99
233_Q 237_E 1.326 0.99
185_A 238_L 1.325 0.99
207_N 210_H 1.325 0.99
183_D 231_H 1.322 0.99
283_F 287_N 1.306 0.99
323_A 338_A 1.302 0.99
41_I 76_L 1.291 0.99
90_L 102_A 1.29 0.99
239_V 295_F 1.282 0.99
159_E 187_Y 1.282 0.99
236_R 282_V 1.282 0.99
76_L 101_A 1.276 0.99
130_M 135_M 1.274 0.99
102_A 135_M 1.256 0.99
276_L 280_A 1.248 0.99
206_F 336_F 1.246 0.98
25_M 28_T 1.229 0.98
139_V 174_V 1.227 0.98
41_I 304_Y 1.22 0.98
199_I 235_L 1.216 0.98
21_R 255_H 1.214 0.98
210_H 220_L 1.213 0.98
196_A 303_F 1.21 0.98
62_R 65_D 1.207 0.98
173_K 305_G 1.207 0.98
186_D 189_R 1.193 0.98
136_P 173_K 1.19 0.98
276_L 313_I 1.18 0.98
13_P 296_C 1.175 0.98
17_H 178_H 1.166 0.97
280_A 289_L 1.16 0.97
8_L 289_L 1.157 0.97
53_V 92_R 1.151 0.97
277_G 320_Q 1.149 0.97
257_R 261_E 1.141 0.97
292_F 296_C 1.14 0.97
124_M 170_T 1.135 0.97
21_R 253_A 1.135 0.97
10_I 314_E 1.133 0.97
60_R 64_L 1.132 0.97
90_L 133_I 1.129 0.97
52_T 55_A 1.123 0.97
50_V 56_A 1.12 0.96
177_E 198_T 1.118 0.96
167_Q 193_E 1.118 0.96
194_R 303_F 1.118 0.96
32_Y 270_F 1.113 0.96
209_N 229_N 1.112 0.96
302_Q 308_V 1.11 0.96
53_V 57_V 1.099 0.96
19_H 251_D 1.098 0.96
10_I 293_E 1.094 0.96
209_N 212_L 1.092 0.96
20_L 42_V 1.089 0.96
124_M 168_R 1.075 0.95
201_P 271_N 1.075 0.95
197_A 245_R 1.071 0.95
248_L 279_Y 1.07 0.95
237_E 240_A 1.069 0.95
185_A 189_R 1.065 0.95
236_R 285_E 1.063 0.95
156_R 160_S 1.06 0.95
106_P 161_V 1.06 0.95
16_W 300_G 1.057 0.95
206_F 220_L 1.056 0.95
297_S 300_G 1.053 0.95
57_V 96_E 1.046 0.94
206_F 226_L 1.046 0.94
58_A 61_Q 1.044 0.94
13_P 37_Y 1.039 0.94
161_V 174_V 1.039 0.94
185_A 243_F 1.038 0.94
242_G 295_F 1.032 0.94
239_V 244_N 1.026 0.94
19_H 178_H 1.02 0.93
123_I 139_V 1.02 0.93
281_T 337_L 1.017 0.93
213_V 216_V 1.016 0.93
248_L 295_F 1.015 0.93
281_T 340_E 1.003 0.93
317_R 347_K 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2z26A20.98281000.231Contact Map0.709
4lfyA20.98281000.279Contact Map0.681
3pnuA20.96551000.409Contact Map0.672
3dc8A20.96551000.41Contact Map0.779
4gz7A10.96841000.414Contact Map0.784
4lcqA10.96841000.419Contact Map0.772
2ftyA40.96551000.421Contact Map0.737
2vr2A10.96841000.425Contact Map0.787
3e74A40.96551000.432Contact Map0.81
4bknA20.96841000.437Contact Map0.785
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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