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OPENSEQ.org
EX7L - Exodeoxyribonuclease 7 large subunit
UniProt: P04994 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11072
Length: 456 (441)
Sequences: 1632
Seq/Len: 3.70
EX7L
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
222_A 244_I 4.428 1.00
193_N 228_S 4.31 1.00
225_I 245_A 4.219 1.00
124_E 223_R 3.89 1.00
419_K 435_D 3.764 1.00
175_A 184_Q 3.539 1.00
131_Y 226_F 3.414 1.00
233_V 263_V 3.327 1.00
159_V 257_S 3.231 1.00
193_N 230_I 3.203 1.00
429_L 440_S 3.195 1.00
423_V 438_I 2.984 1.00
141_C 168_P 2.982 1.00
431_T 440_S 2.958 1.00
182_P 218_D 2.84 1.00
409_T 431_T 2.747 1.00
126_L 223_R 2.693 1.00
186_V 221_V 2.632 1.00
433_L 438_I 2.592 1.00
74_P 102_M 2.562 1.00
181_A 215_S 2.477 1.00
420_V 435_D 2.44 1.00
193_N 229_R 2.419 1.00
218_D 221_V 2.414 1.00
222_A 248_V 2.394 1.00
36_I 39_F 2.372 1.00
75_Q 78_Q 2.329 1.00
60_C 99_V 2.307 1.00
189_I 203_V 2.245 1.00
156_I 204_G 2.232 1.00
174_A 185_I 2.145 1.00
189_I 201_L 2.139 1.00
144_V 156_I 2.122 1.00
225_I 232_V 2.119 1.00
202_I 263_V 2.112 1.00
143_G 198_C 2.105 1.00
200_V 263_V 2.089 1.00
156_I 202_I 2.081 1.00
409_T 440_S 2.033 1.00
288_Y 292_R 2.012 1.00
59_R 94_D 2.003 1.00
204_G 235_A 1.986 1.00
185_I 221_V 1.978 1.00
119_A 123_A 1.965 1.00
378_Q 382_T 1.947 1.00
254_P 258_A 1.93 1.00
411_A 427_E 1.899 1.00
36_I 80_V 1.897 1.00
429_L 442_V 1.885 1.00
242_V 247_F 1.884 1.00
115_E 119_A 1.857 1.00
410_T 432_R 1.854 1.00
174_A 184_Q 1.845 1.00
192_A 201_L 1.836 0.99
49_F 99_V 1.829 0.99
186_V 220_R 1.815 0.99
135_L 251_L 1.809 0.99
19_V 88_L 1.8 0.99
204_G 236_V 1.796 0.99
120_K 219_E 1.777 0.99
430_T 437_W 1.763 0.99
39_F 47_W 1.757 0.99
407_S 431_T 1.721 0.99
221_V 224_A 1.719 0.99
407_S 433_L 1.693 0.99
143_G 192_A 1.677 0.99
61_A 96_Q 1.673 0.99
157_L 169_V 1.654 0.99
333_Q 337_T 1.653 0.99
417_L 423_V 1.652 0.99
152_A 240_T 1.641 0.99
181_A 185_I 1.62 0.98
47_W 67_N 1.607 0.98
143_G 201_L 1.603 0.98
160_L 169_V 1.598 0.98
10_F 18_T 1.581 0.98
408_V 416_V 1.574 0.98
145_I 203_V 1.572 0.98
239_E 252_R 1.565 0.98
152_A 204_G 1.56 0.98
82_V 102_M 1.558 0.98
20_R 24_E 1.548 0.98
189_I 232_V 1.528 0.98
317_T 320_E 1.518 0.97
394_E 397_S 1.513 0.97
424_K 427_E 1.492 0.97
203_V 234_S 1.49 0.97
174_A 188_A 1.485 0.97
32_I 97_I 1.483 0.97
219_E 223_R 1.466 0.97
72_F 102_M 1.465 0.97
190_E 227_T 1.452 0.96
423_V 427_E 1.443 0.96
382_T 385_R 1.441 0.96
80_V 102_M 1.436 0.96
16_N 95_Y 1.434 0.96
47_W 70_V 1.427 0.96
19_V 95_Y 1.421 0.96
186_V 189_I 1.421 0.96
410_T 430_T 1.413 0.96
17_Q 90_E 1.404 0.95
401_T 404_R 1.396 0.95
88_L 95_Y 1.393 0.95
24_E 87_T 1.382 0.95
203_V 245_A 1.381 0.95
112_Q 116_Q 1.378 0.95
109_L 113_K 1.374 0.95
162_R 261_E 1.374 0.95
139_A 265_R 1.365 0.94
175_A 180_D 1.364 0.94
226_F 248_V 1.355 0.94
50_T 57_Q 1.353 0.94
164_D 265_R 1.347 0.94
244_I 248_V 1.336 0.93
87_T 98_I 1.334 0.93
145_I 189_I 1.332 0.93
62_M 72_F 1.324 0.93
19_V 58_V 1.321 0.93
39_F 74_P 1.319 0.93
189_I 221_V 1.307 0.92
201_L 230_I 1.306 0.92
40_T 76_H 1.296 0.92
214_W 217_N 1.296 0.92
115_E 118_K 1.295 0.92
18_T 26_E 1.289 0.92
31_W 83_R 1.286 0.92
36_I 102_M 1.276 0.91
116_Q 120_K 1.274 0.91
114_Y 244_I 1.272 0.91
251_L 262_V 1.271 0.91
110_L 214_W 1.268 0.91
185_I 203_V 1.262 0.91
210_L 214_W 1.262 0.91
423_V 429_L 1.26 0.91
428_M 443_K 1.255 0.90
394_E 400_S 1.251 0.90
172_Y 192_A 1.25 0.90
180_D 183_G 1.245 0.90
62_M 102_M 1.243 0.90
344_L 347_R 1.236 0.89
58_V 84_A 1.236 0.89
61_A 98_I 1.234 0.89
133_K 229_R 1.231 0.89
150_G 153_L 1.228 0.89
325_R 329_A 1.22 0.89
86_I 95_Y 1.216 0.88
189_I 225_I 1.214 0.88
158_H 162_R 1.213 0.88
185_I 189_I 1.211 0.88
33_S 79_Q 1.211 0.88
182_P 220_R 1.208 0.88
187_R 190_E 1.19 0.87
136_P 200_V 1.19 0.87
190_E 194_Q 1.185 0.87
186_V 190_E 1.182 0.86
419_K 422_Q 1.181 0.86
118_K 247_F 1.179 0.86
126_L 219_E 1.175 0.86
337_T 340_Q 1.174 0.86
83_R 101_S 1.158 0.85
418_K 422_Q 1.156 0.85
41_Q 73_R 1.154 0.85
10_F 15_L 1.153 0.84
423_V 442_V 1.15 0.84
144_V 169_V 1.146 0.84
82_V 99_V 1.144 0.84
420_V 433_L 1.142 0.84
165_P 265_R 1.125 0.82
280_R 284_A 1.117 0.82
142_V 167_L 1.116 0.82
113_K 117_L 1.111 0.81
429_L 438_I 1.11 0.81
428_M 439_E 1.109 0.81
143_G 172_Y 1.107 0.81
116_Q 119_A 1.104 0.81
292_R 295_R 1.101 0.81
201_L 228_S 1.092 0.80
42_P 149_T 1.085 0.79
203_V 235_A 1.083 0.79
38_N 76_H 1.081 0.79
373_E 377_A 1.079 0.79
251_L 254_P 1.077 0.79
167_L 264_S 1.077 0.79
142_V 200_V 1.075 0.78
384_E 388_N 1.074 0.78
423_V 433_L 1.072 0.78
266_N 269_E 1.072 0.78
37_S 52_K 1.062 0.77
139_A 142_V 1.058 0.77
158_H 254_P 1.052 0.76
397_S 401_T 1.051 0.76
172_Y 191_L 1.047 0.76
438_I 442_V 1.042 0.75
104_P 116_Q 1.036 0.75
19_V 23_L 1.032 0.74
62_M 70_V 1.032 0.74
15_L 58_V 1.023 0.73
428_M 441_E 1.022 0.73
84_A 97_I 1.019 0.73
31_W 81_L 1.017 0.73
43_A 149_T 1.014 0.72
362_T 366_Q 1.011 0.72
377_A 380_S 1.007 0.72
148_K 173_P 1.004 0.71
186_V 218_D 1.002 0.71
124_E 219_E 1.001 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4gnxB20.267598.90.92Contact Map0.749
4joiA20.287398.10.937Contact Map0.69
3kdfD20.263297.20.947Contact Map0.737
3dm3A30.201896.90.95Contact Map0.711
3au7A10.298296.80.951Contact Map0.59
3e0eA10.19396.30.953Contact Map0.722
1o7iA20.234695.70.956Contact Map0.634
3kf6A10.296195.20.957Contact Map0.693
2hpiA10.412394.60.958Contact Map0.602
1txyA20.184293.50.96Contact Map0.674
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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