May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
SYQ - Glutamine--tRNA ligase
UniProt: P00962 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10390
Length: 554 (548)
Sequences: 1265
Seq/Len: 2.31
SYQ
Paralog alert: 0.10 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
143_N 148_D 4.938 1.00
150_S 154_N 4.678 1.00
112_I 159_E 4.15 1.00
167_E 170_K 3.973 1.00
76_I 80_E 3.702 1.00
352_L 418_I 3.697 1.00
124_E 171_A 3.693 1.00
160_K 165_G 3.618 1.00
156_A 160_K 3.522 1.00
468_V 504_A 3.448 1.00
105_D 205_K 3.397 1.00
424_E 433_T 3.131 1.00
355_E 435_F 3.043 1.00
125_L 133_Y 3.039 1.00
115_I 158_F 2.849 1.00
275_N 279_T 2.821 1.00
348_D 390_R 2.794 1.00
365_T 379_Q 2.729 1.00
426_D 430_N 2.694 1.00
395_E 425_K 2.651 1.00
87_E 92_H 2.614 1.00
487_D 490_S 2.587 1.00
119_L 247_N 2.521 1.00
366_M 414_N 2.452 1.00
467_P 503_F 2.442 1.00
168_E 196_F 2.431 1.00
405_V 408_K 2.359 1.00
17_D 58_Y 2.337 1.00
107_L 219_S 2.301 1.00
39_Y 77_E 2.282 1.00
160_K 166_F 2.278 1.00
350_V 434_I 2.229 1.00
159_E 163_A 2.21 1.00
353_V 435_F 2.209 1.00
113_E 117_K 2.168 1.00
363_M 379_Q 2.161 1.00
126_T 129_Q 2.155 1.00
512_V 515_K 2.127 1.00
198_E 204_N 2.117 1.00
111_A 173_L 2.111 1.00
105_D 109_A 2.098 1.00
143_N 179_M 2.068 0.99
276_L 280_D 2.067 0.99
409_E 451_R 2.058 0.99
157_L 166_F 2.037 0.99
47_S 231_T 2.01 0.99
156_A 165_G 2.003 0.99
470_I 502_G 1.963 0.99
422_R 435_F 1.96 0.99
100_S 215_T 1.945 0.99
18_E 21_A 1.923 0.99
383_S 461_S 1.92 0.99
105_D 162_R 1.906 0.99
541_R 544_G 1.877 0.99
162_R 208_I 1.868 0.99
422_R 434_I 1.868 0.99
303_T 335_D 1.865 0.99
102_D 201_Q 1.862 0.99
345_A 504_A 1.841 0.98
351_K 385_E 1.83 0.98
167_E 196_F 1.813 0.98
47_S 51_N 1.806 0.98
107_L 215_T 1.805 0.98
365_T 377_S 1.77 0.98
13_R 57_D 1.763 0.98
335_D 339_N 1.746 0.98
83_K 97_V 1.742 0.98
49_C 91_F 1.737 0.98
246_D 253_H 1.73 0.97
389_D 522_E 1.723 0.97
79_V 200_H 1.717 0.97
305_A 339_N 1.716 0.97
63_N 96_N 1.716 0.97
213_D 237_N 1.695 0.97
461_S 464_H 1.674 0.97
47_S 229_L 1.673 0.97
409_E 439_D 1.664 0.97
191_L 244_V 1.661 0.97
185_V 237_N 1.65 0.96
133_Y 142_K 1.642 0.96
444_S 449_D 1.64 0.96
112_I 116_N 1.638 0.96
511_A 517_F 1.631 0.96
345_A 468_V 1.63 0.96
372_K 375_M 1.624 0.96
337_N 371_N 1.62 0.96
129_Q 132_E 1.594 0.95
355_E 422_R 1.581 0.95
106_Q 110_Y 1.576 0.95
413_R 520_E 1.575 0.95
108_H 208_I 1.561 0.95
381_P 506_P 1.552 0.94
110_Y 218_I 1.547 0.94
151_V 154_N 1.543 0.94
357_Y 360_E 1.526 0.94
274_L 292_P 1.524 0.94
156_A 166_F 1.509 0.93
302_Y 328_L 1.501 0.93
439_D 451_R 1.5 0.93
149_R 153_E 1.493 0.93
478_S 491_V 1.493 0.93
495_E 498_V 1.486 0.93
116_N 152_E 1.478 0.92
353_V 433_T 1.466 0.92
353_V 385_E 1.461 0.92
309_E 313_R 1.456 0.92
124_E 149_R 1.455 0.92
52_F 62_C 1.454 0.91
299_R 528_D 1.437 0.91
519_F 539_F 1.433 0.91
424_E 435_F 1.428 0.91
29_H 61_Q 1.417 0.90
113_E 249_T 1.415 0.90
122_V 173_L 1.411 0.90
354_I 438_Y 1.406 0.90
469_E 499_I 1.396 0.89
110_Y 217_C 1.392 0.89
284_E 497_L 1.387 0.89
394_R 397_A 1.38 0.88
479_V 491_V 1.376 0.88
472_L 525_F 1.374 0.88
78_Y 275_N 1.374 0.88
83_K 87_E 1.372 0.88
424_E 434_I 1.36 0.87
217_C 244_V 1.356 0.87
477_F 482_P 1.356 0.87
414_N 520_E 1.348 0.87
305_A 335_D 1.346 0.87
47_S 50_L 1.342 0.86
419_K 437_T 1.339 0.86
260_S 321_N 1.336 0.86
369_H 375_M 1.331 0.86
348_D 498_V 1.327 0.86
123_D 130_I 1.326 0.86
431_I 434_I 1.321 0.85
381_P 464_H 1.32 0.85
357_Y 383_S 1.311 0.85
276_L 488_F 1.299 0.84
355_E 433_T 1.297 0.84
444_S 448_A 1.295 0.84
9_T 13_R 1.292 0.84
29_H 63_N 1.291 0.83
421_E 437_T 1.289 0.83
125_L 144_S 1.288 0.83
276_L 489_L 1.287 0.83
409_E 419_K 1.286 0.83
269_M 275_N 1.28 0.83
352_L 434_I 1.268 0.82
10_N 57_D 1.267 0.82
18_E 22_S 1.264 0.82
136_T 139_Q 1.264 0.82
343_A 368_N 1.261 0.81
352_L 386_I 1.258 0.81
351_K 433_T 1.25 0.81
406_L 420_A 1.25 0.81
63_N 98_R 1.247 0.80
196_F 207_C 1.245 0.80
185_V 239_R 1.243 0.80
331_C 334_E 1.241 0.80
218_I 248_I 1.24 0.80
117_K 247_N 1.238 0.80
313_R 331_C 1.237 0.80
527_L 532_S 1.234 0.79
46_K 262_L 1.225 0.79
261_R 270_S 1.222 0.79
80_E 83_K 1.221 0.78
29_H 225_I 1.221 0.78
185_V 236_D 1.211 0.78
108_H 159_E 1.206 0.77
116_N 155_L 1.199 0.77
266_Y 480_P 1.196 0.76
130_I 172_C 1.194 0.76
106_Q 222_L 1.194 0.76
394_R 398_N 1.191 0.76
137_L 236_D 1.183 0.75
52_F 91_F 1.182 0.75
30_T 55_A 1.18 0.75
350_V 390_R 1.179 0.75
125_L 142_K 1.175 0.75
229_L 316_V 1.175 0.75
29_H 224_G 1.175 0.75
10_N 54_I 1.173 0.74
141_G 184_I 1.17 0.74
124_E 150_S 1.168 0.74
244_V 248_I 1.166 0.74
444_S 450_G 1.166 0.74
109_A 112_I 1.165 0.74
47_S 86_V 1.163 0.74
86_V 231_T 1.157 0.73
303_T 332_I 1.155 0.73
416_Y 438_Y 1.139 0.71
191_L 214_F 1.137 0.71
61_Q 96_N 1.135 0.71
51_N 231_T 1.133 0.71
274_L 296_G 1.129 0.70
332_I 542_T 1.126 0.70
118_G 154_N 1.125 0.70
472_L 541_R 1.124 0.70
260_S 317_T 1.123 0.70
323_I 327_S 1.121 0.70
178_D 181_S 1.119 0.69
533_T 536_K 1.119 0.69
359_G 463_A 1.113 0.69
309_E 331_C 1.108 0.68
341_P 368_N 1.107 0.68
465_A 506_P 1.107 0.68
108_H 206_W 1.104 0.68
274_L 291_M 1.101 0.68
346_V 460_V 1.1 0.68
282_H 489_L 1.1 0.68
516_A 542_T 1.097 0.67
284_E 531_H 1.096 0.67
100_S 219_S 1.095 0.67
424_E 432_T 1.094 0.67
50_L 231_T 1.094 0.67
117_K 249_T 1.093 0.67
426_D 432_T 1.093 0.67
63_N 94_S 1.093 0.67
110_Y 222_L 1.091 0.67
419_K 439_D 1.091 0.67
64_L 83_K 1.088 0.66
367_P 413_R 1.086 0.66
397_A 400_Q 1.081 0.66
363_M 381_P 1.076 0.65
471_R 531_H 1.074 0.65
402_K 405_V 1.074 0.65
85_D 295_S 1.073 0.65
123_D 133_Y 1.069 0.64
303_T 306_S 1.068 0.64
221_A 252_V 1.068 0.64
348_D 391_A 1.068 0.64
467_P 501_Q 1.065 0.64
17_D 57_D 1.063 0.64
177_I 189_P 1.062 0.64
113_E 116_N 1.061 0.63
388_I 393_F 1.06 0.63
22_S 25_H 1.06 0.63
343_A 507_S 1.059 0.63
397_A 408_K 1.058 0.63
116_N 159_E 1.056 0.63
86_V 91_F 1.052 0.62
92_H 98_R 1.049 0.62
237_N 240_L 1.048 0.62
47_S 311_C 1.045 0.62
12_I 257_Y 1.041 0.61
383_S 464_H 1.038 0.61
420_A 434_I 1.034 0.60
183_F 239_R 1.029 0.60
20_L 255_R 1.027 0.60
131_R 137_L 1.026 0.60
217_C 240_L 1.024 0.59
513_A 527_L 1.022 0.59
297_L 307_I 1.021 0.59
12_I 50_L 1.021 0.59
215_T 219_S 1.019 0.59
504_A 519_F 1.017 0.59
417_V 449_D 1.017 0.59
10_N 17_D 1.016 0.58
127_P 131_R 1.009 0.58
124_E 170_K 1.008 0.58
54_I 229_L 1.008 0.58
48_I 91_F 1.002 0.57
215_T 222_L 1 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1qtqA10.99821000.23Contact Map0.711
2hz7A10.98381000.242Contact Map0.707
4h3sA10.98921000.286Contact Map0.672
3aiiA10.86821000.386Contact Map0.586
4griA20.81951000.73Contact Map0.489
2cfoA20.79421000.742Contact Map0.52
2ja2A10.80321000.75Contact Map0.449
1j09A10.75631000.752Contact Map0.52
3al0C10.76711000.753Contact Map0.516
4g6zA10.73831000.753Contact Map0.502
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 2.4881 seconds.