May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
THRC - Threonine synthase
UniProt: P00934 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11000
Length: 428 (425)
Sequences: 2619
Seq/Len: 6.16
THRC
Paralog alert: 0.68 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
229_A 372_L 4.236 1.00
159_R 183_D 4.061 1.00
268_R 321_W 3.939 1.00
243_V 256_G 3.797 1.00
335_T 363_D 3.628 1.00
51_F 220_L 3.54 1.00
74_E 78_A 3.47 1.00
223_I 227_F 3.221 1.00
256_G 374_L 3.171 1.00
26_N 317_R 3.057 1.00
332_D 335_T 2.993 1.00
78_A 236_E 2.988 1.00
229_A 256_G 2.949 1.00
86_V 372_L 2.906 1.00
84_A 101_G 2.806 1.00
88_N 92_D 2.755 1.00
238_R 370_Y 2.665 1.00
152_K 178_E 2.64 1.00
256_G 269_F 2.594 1.00
160_G 163_S 2.587 1.00
154_V 180_V 2.439 1.00
126_P 152_K 2.429 1.00
50_D 53_T 2.407 1.00
242_V 270_I 2.383 1.00
208_L 214_I 2.335 1.00
329_A 360_A 2.289 1.00
243_V 269_F 2.247 1.00
342_E 362_R 2.21 1.00
103_T 144_A 2.151 1.00
341_R 390_L 2.138 1.00
240_Q 267_K 2.098 1.00
341_R 344_K 2.097 1.00
337_Q 352_P 2.084 1.00
154_V 178_E 2.083 1.00
226_Y 259_A 2.078 1.00
334_E 338_Q 2.062 1.00
156_L 195_Q 2.041 1.00
233_L 372_L 2.038 1.00
361_L 373_F 2.006 1.00
68_P 120_H 2.003 1.00
313_E 322_Q 1.983 1.00
88_N 94_G 1.943 1.00
360_A 364_Q 1.931 1.00
80_F 101_G 1.926 1.00
226_Y 256_G 1.907 1.00
195_Q 199_D 1.858 1.00
231_A 235_Q 1.833 1.00
233_L 370_Y 1.816 1.00
159_R 163_S 1.794 1.00
298_S 336_T 1.78 1.00
244_S 270_I 1.764 1.00
242_V 371_G 1.755 1.00
230_V 264_L 1.734 1.00
73_E 227_F 1.723 1.00
270_I 321_W 1.705 1.00
98_L 376_T 1.701 1.00
171_C 178_E 1.697 1.00
272_A 360_A 1.677 1.00
227_F 264_L 1.668 1.00
127_V 195_Q 1.662 1.00
342_E 345_E 1.638 1.00
25_K 288_W 1.619 1.00
76_V 80_F 1.61 1.00
72_L 76_V 1.595 0.99
359_R 363_D 1.572 0.99
260_K 325_E 1.565 0.99
78_A 116_Q 1.558 0.99
272_A 331_V 1.551 0.99
31_F 38_F 1.55 0.99
242_V 364_Q 1.54 0.99
242_V 268_R 1.532 0.99
323_L 360_A 1.528 0.99
354_A 375_G 1.524 0.99
92_D 368_G 1.52 0.99
339_T 359_R 1.506 0.99
159_R 162_I 1.495 0.99
69_Q 73_E 1.491 0.99
350_S 358_Y 1.486 0.99
358_Y 373_F 1.483 0.99
261_S 320_I 1.474 0.99
253_L 271_A 1.468 0.99
163_S 166_Q 1.46 0.99
68_P 71_I 1.448 0.99
29_L 39_S 1.448 0.99
94_G 370_Y 1.447 0.99
111_G 145_F 1.446 0.99
163_S 388_A 1.444 0.99
339_T 358_Y 1.435 0.99
183_D 414_P 1.432 0.99
361_L 371_G 1.43 0.99
315_L 318_R 1.421 0.99
162_I 181_A 1.42 0.99
244_S 361_L 1.402 0.98
331_V 359_R 1.401 0.98
275_V 332_D 1.4 0.98
103_T 108_D 1.389 0.98
145_F 210_S 1.388 0.98
60_S 69_Q 1.385 0.98
75_R 148_L 1.372 0.98
212_N 216_I 1.372 0.98
157_Y 179_T 1.37 0.98
241_L 369_E 1.365 0.98
337_Q 389_I 1.361 0.98
354_A 376_T 1.361 0.98
338_Q 342_E 1.358 0.98
52_V 216_I 1.353 0.98
230_V 234_P 1.349 0.98
282_F 307_N 1.345 0.98
73_E 77_R 1.345 0.98
164_P 167_E 1.344 0.98
144_A 173_L 1.343 0.98
94_G 233_L 1.339 0.98
80_F 84_A 1.33 0.97
190_Q 194_K 1.318 0.97
77_R 235_Q 1.31 0.97
340_M 386_V 1.299 0.97
343_L 350_S 1.299 0.97
270_I 360_A 1.292 0.97
146_Y 153_V 1.292 0.97
233_L 238_R 1.287 0.97
190_Q 214_I 1.284 0.97
331_V 363_D 1.284 0.97
270_I 364_Q 1.272 0.96
86_V 233_L 1.266 0.96
168_K 390_L 1.264 0.96
241_L 372_L 1.264 0.96
127_V 152_K 1.259 0.96
229_A 260_K 1.255 0.96
72_L 224_C 1.253 0.96
360_A 363_D 1.25 0.96
71_I 120_H 1.248 0.96
223_I 259_A 1.245 0.96
84_A 109_F 1.237 0.96
49_L 57_K 1.227 0.95
23_L 216_I 1.226 0.95
227_F 259_A 1.211 0.95
361_L 365_L 1.208 0.95
272_A 330_A 1.197 0.95
182_I 413_L 1.194 0.94
114_M 166_Q 1.185 0.94
384_E 387_E 1.18 0.94
142_A 146_Y 1.173 0.94
37_E 204_V 1.172 0.94
128_T 146_Y 1.172 0.94
275_V 330_A 1.171 0.94
335_T 359_R 1.171 0.94
243_V 266_V 1.164 0.93
336_T 356_V 1.161 0.93
95_C 348_Y 1.151 0.93
56_A 76_V 1.151 0.93
56_A 73_E 1.148 0.93
297_L 333_D 1.138 0.92
243_V 372_L 1.128 0.92
280_P 328_Y 1.123 0.92
418_A 421_R 1.118 0.91
414_P 419_A 1.109 0.91
115_A 166_Q 1.108 0.91
352_P 389_I 1.108 0.91
343_L 349_T 1.102 0.91
92_D 370_Y 1.098 0.90
254_T 258_L 1.097 0.90
275_V 333_D 1.093 0.90
25_K 317_R 1.076 0.89
62_F 123_G 1.073 0.89
14_S 17_Q 1.062 0.88
385_S 389_I 1.062 0.88
387_E 391_G 1.06 0.88
282_F 285_D 1.055 0.88
190_Q 294_Q 1.048 0.88
219_L 311_R 1.044 0.87
167_E 408_L 1.043 0.87
67_I 71_I 1.04 0.87
162_I 171_C 1.037 0.87
46_M 49_L 1.035 0.87
238_R 241_L 1.034 0.87
143_H 146_Y 1.031 0.86
331_V 360_A 1.029 0.86
142_A 155_I 1.025 0.86
387_E 393_T 1.025 0.86
244_S 364_Q 1.022 0.86
234_P 239_N 1.02 0.86
93_V 365_L 1.011 0.85
228_E 232_Q 1.009 0.85
159_R 181_A 1.008 0.85
172_T 341_R 1.007 0.85
314_E 318_R 1.006 0.84
271_A 322_Q 1.004 0.84
108_D 144_A 1.003 0.84
44_D 52_V 1.002 0.84
178_E 181_A 1.002 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1kl7A211000.243Contact Map0.562
3v7nA10.99771000.26Contact Map0.519
4f4fA20.99771000.27Contact Map0.571
1vb3A111000.274Contact Map0.508
1e5xA20.92521000.501Contact Map0.602
3iauA20.81781000.578Contact Map0.535
2o2eA20.86211000.58Contact Map0.583
1x1qA20.86211000.59Contact Map0.654
4negA20.83411000.593Contact Map0.727
1wkvA20.78271000.6Contact Map0.607
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 1.1304 seconds.