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OPENSEQ.org
4Y0Y_10_20
Genes: A B A+B
Length: 216 51 267
Sequences: 14597 2483 52
Seq/Len: 67.58 48.69 0.19
MirrorTree (Pazo et al. 2001) 0.11
Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.

[Show HHblits results] - Maybe useful in deciding what regions to trim.
Δgene Ratio of paralogs Joined
A B Seq/Len
1 0.19 0.18 0.02
2 0.20 0.19 0.02
5 0.21 0.21 0.04
10 0.22 0.22 0.10
20 0.23 0.22 0.19
100 0.25 0.23 0.45
∞ 0.29 0.25 0.58
Paired alignment generation
0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
Sequence A E-value:
Iterations:
Sequence B E-value:
Iterations:
Δgene MSA
Figure 1: The effect of Δgene on ratio of paralogs in the genome for each gene, and the number of sequences in the resulting joined alignment. Figure 2: Distribution of Δgene across all genomes. Figure 3: Current parameters. You can use the form to adjust the parameters and resubmit the job!
GREMLIN results (Scaled_score > 1):
Figure 4: The darker and larger the blue dots, the higher strength in coevolution. 		Inter Residue pairs sorted by strength in coevolution signal:
i j Scaled Score Prob I_Prob
173_C 47_C 1.29 0.21 0.00
142_I 40_N 1.26 0.20 0.00
187_L 19_Y 1.25 0.20 0.00
120_G 37_K 1.22 0.19 0.00
202_K 43_S 1.19 0.18 0.00
59_E 43_S 1.19 0.18 0.00
48_V 31_Y 1.17 0.17 0.00
173_C 51_C 1.17 0.17 0.00
190_I 23_A 1.16 0.17 0.00
18_L 50_T 1.15 0.16 0.00
74_P 9_P 1.13 0.16 0.00
159_N 19_Y 1.08 0.14 0.00
34_W 44_A 1.07 0.14 0.00
211_N 43_S 1.07 0.14 0.00
191_V 16_R 1.05 0.13 0.00
92_S 19_Y 1.03 0.13 0.00
190_I 17_Y 1.02 0.12 0.00
6_T 17_Y 1.00 0.12 0.00
110_A 24_G 1.00 0.12 0.00
30_I 31_Y 0.99 0.12 0.00
120_G 47_C 0.99 0.12 0.00
141_P 19_Y 0.98 0.12 0.00
1_I 43_S 0.98 0.11 0.00
39_A 31_Y 0.97 0.11 0.00
51_G 51_C 0.96 0.11 0.00
14_Y 37_K 0.96 0.11 0.00
32_S 43_S 0.95 0.11 0.00
23_H 40_N 0.94 0.11 0.00
85_I 7_T 0.94 0.11 0.00
103_I 17_Y 0.93 0.10 0.00
83_N 44_A 0.93 0.10 0.00
122_G 47_C 0.93 0.10 0.00
207_T 44_A 0.92 0.10 0.00
162_C 26_C 0.92 0.10 0.00
162_C 39_N 0.92 0.10 0.00
65_I 27_Q 0.91 0.10 0.00
88_I 29_F 0.91 0.10 0.00
84_D 10_C 0.90 0.10 0.00
84_D 34_C 0.90 0.10 0.00
178_G 26_C 0.90 0.10 0.00
178_G 39_N 0.90 0.10 0.00
88_I 17_Y 0.90 0.10 0.00
132_P 40_N 0.90 0.10 0.00
55_I 17_Y 0.89 0.10 0.00
104_S 36_A 0.89 0.10 0.00
173_C 26_C 0.89 0.09 0.00
173_C 39_N 0.89 0.09 0.00
165_Y 43_S 0.88 0.09 0.00
180_P 19_Y 0.88 0.09 0.00
96_L 4_P 0.88 0.09 0.00
161_F 5_P 0.88 0.09 0.00
152_Y 19_Y 0.87 0.09 0.00
148_C 26_C 0.87 0.09 0.00
148_C 39_N 0.87 0.09 0.00
183_C 43_S 0.87 0.09 0.00
101_A 44_A 0.86 0.09 0.00
52_E 40_N 0.86 0.09 0.00
196_G 31_Y 0.85 0.09 0.00
25_C 26_C 0.85 0.09 0.00
25_C 39_N 0.85 0.09 0.00
120_G 51_C 0.85 0.09 0.00
65_I 49_R 0.85 0.09 0.00
215_W 19_Y 0.85 0.09 0.00
175_G 37_K 0.85 0.09 0.00
26_G 19_Y 0.85 0.09 0.00
175_G 47_C 0.84 0.09 0.00
49_R 43_S 0.83 0.08 0.00
36_V 12_A 0.83 0.08 0.00
74_P 32_G 0.82 0.08 0.00
138_L 7_T 0.82 0.08 0.00
173_C 29_F 0.82 0.08 0.00
99_R 25_L 0.82 0.08 0.00
185_G 4_P 0.81 0.08 0.00
131_Y 17_Y 0.81 0.08 0.00
37_S 31_Y 0.81 0.08 0.00
119_S 15_I 0.81 0.08 0.00
16_V 50_T 0.81 0.08 0.00
189_G 26_C 0.81 0.08 0.00
189_G 39_N 0.81 0.08 0.00
73_H 47_C 0.81 0.08 0.00
158_S 18_F 0.80 0.08 0.00
185_G 45_E 0.80 0.08 0.00
78_S 46_D 0.80 0.08 0.00
151_A 24_G 0.80 0.08 0.00
203_P 4_P 0.80 0.08 0.00
133_D 49_R 0.79 0.08 0.00
4_G 10_C 0.79 0.08 0.00
4_G 34_C 0.79 0.08 0.00
67_A 24_G 0.79 0.08 0.00
41_C 26_C 0.79 0.08 0.00
Figure 5: The i (protein A) and j (protein B) are positions as given in the query sequences.

Scaled Score = raw_score/average(raw_scores)
Prob = P(contact | scaled_score, seq/len)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)
ID Seq/Len Name Options I_Prob Status
11600 0.58 4Y0Y_10_inf Δgene:(1, ∞) A:(1E-10, 8) B:(1E-10, 8) msa: HHblits (2015_06) 0.00 Done - Shared
11597 0.64 4Y0Y_6_inf Δgene:(1, ∞) A:(1E-06, 8) B:(1E-06, 8) msa: HHblits (2015_06) 0.00 Done - Shared
11596 0.67 4Y0Y_4_inf Δgene:(1, ∞) A:(1E-04, 8) B:(1E-04, 8) msa: HHblits (2015_06) 0.00 Done - Shared
11594 0.68 4Y0Y_2_inf Δgene:(1, ∞) A:(1E-02, 8) B:(1E-02, 8) msa: HHblits (2015_06) 0.00 Done - Shared
11564 0.2 4Y0Y_4_20 Δgene:(1, 20) A:(1E-04, 8) B:(1E-04, 8) msa: HHblits (2015_06) 0.00 Done - Shared
11545 0.19 4Y0Y_10_20 Δgene:(1, 20) A:(1E-10, 8) B:(1E-10, 8) msa: HHblits (2015_06) 0.00 Done - Shared
11478 0.2 4Y0Y_6_20 Δgene:(1, 20) A:(1E-06, 8) B:(1E-06, 8) msa: HHblits (2015_06) 0.00 Done - Shared
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