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OPENSEQ.org
4HEA_H - 4HEA_M
UniProt: Q60019 - Q56228 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 834
Sequences: 3115
Seq/Len: 4.05
I_Prob: 0.11
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaMU:HQ:LT:NVContact Map
4he8GM:CH:FL:INContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
155_S 200_A 1.14 0.11
56_L 397_L 1.14 0.11
64_I 81_T 1.10 0.10
67_I 290_L 0.98 0.07
122_I 317_A 0.98 0.07
88_I 296_A 0.97 0.07
74_V 329_A 0.95 0.06
246_M 264_A 0.93 0.06
122_I 276_F 0.91 0.05
14_A 393_A 0.91 0.05
129_S 291_S 0.90 0.05
17_A 360_I 0.89 0.05
311_G 233_L 0.88 0.05
238_S 272_A 0.87 0.05
177_V 252_G 0.87 0.05
237_S 95_F 0.87 0.05
262_L 193_V 0.86 0.04
238_S 371_L 0.82 0.04
210_S 233_L 0.82 0.04
129_S 260_L 0.82 0.04
189_Q 310_G 0.81 0.04
53_P 338_T 0.81 0.04
121_G 66_G 0.81 0.04
82_F 344_Y 0.81 0.04
136_I 386_K 0.80 0.04
64_I 386_K 0.79 0.03
250_I 261_L 0.79 0.03
168_L 155_G 0.79 0.03
254_T 299_G 0.79 0.03
189_Q 376_G 0.78 0.03
207_L 324_G 0.78 0.03
118_L 393_A 0.77 0.03
125_L 374_F 0.77 0.03
266_G 249_A 0.77 0.03
57_L 120_V 0.76 0.03
138_L 321_Y 0.76 0.03
309_G 372_S 0.76 0.03
234_T 205_T 0.75 0.03
167_G 148_F 0.75 0.03
80_F 179_D 0.75 0.03
37_R 216_P 0.75 0.03
49_N 159_M 0.74 0.03
150_L 361_L 0.74 0.03
159_L 290_L 0.74 0.03
97_F 322_T 0.74 0.03
128_V 338_T 0.73 0.03
129_S 379_L 0.73 0.03
80_F 360_I 0.73 0.03
172_A 164_L 0.73 0.03
34_I 210_L 0.73 0.03
199_A 105_L 0.73 0.03
201_P 124_A 0.72 0.03
87_L 116_L 0.72 0.03
148_S 266_L 0.72 0.03
95_L 304_T 0.72 0.03
81_L 150_L 0.72 0.03
152_S 258_G 0.72 0.03
93_A 317_A 0.72 0.03
210_S 208_F 0.72 0.03
289_F 312_L 0.71 0.03
131_L 95_F 0.71 0.03
265_G 433_A 0.71 0.03
24_L 257_Q 0.71 0.03
180_L 312_L 0.71 0.03
150_L 399_V 0.71 0.03
132_A 256_A 0.71 0.03
174_V 398_S 0.71 0.03
321_F 324_G 0.70 0.03
77_A 324_G 0.70 0.02
117_N 375_P 0.70 0.02
141_W 225_G 0.70 0.02
199_A 154_V 0.69 0.02
174_V 384_A 0.69 0.02
309_G 257_Q 0.69 0.02
96_A 241_F 0.69 0.02
261_T 301_F 0.69 0.02
38_L 399_V 0.69 0.02
322_L 82_V 0.69 0.02
138_L 165_G 0.69 0.02
120_L 89_A 0.69 0.02
261_T 131_L 0.69 0.02
126_F 260_L 0.69 0.02
280_F 312_L 0.69 0.02
164_L 259_L 0.68 0.02
148_S 430_W 0.68 0.02
96_A 294_G 0.68 0.02
46_M 84_L 0.68 0.02
125_L 300_V 0.68 0.02
316_L 281_F 0.68 0.02
289_F 355_A 0.68 0.02
305_L 325_L 0.68 0.02
73_V 290_L 0.68 0.02
313_L 113_R 0.68 0.02
80_F 393_A 0.68 0.02
261_T 120_V 0.67 0.02
261_T 270_Y 0.67 0.02
225_E 292_H 0.67 0.02
206_Y 158_P 0.67 0.02
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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