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OPENSEQ.org
4HEA_K - 4HEA_L
UniProt: Q56226 - Q56227 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 701
Sequences: 3480
Seq/Len: 5.06
I_Prob: 0.11
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3rkoBL:CM:DN:GKContact Map
4heaLT:MU:NV:KSContact Map
4he8FL:GM:IN:EKContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
73_G 450_A 1.12 0.11
68_V 90_Y 0.97 0.07
74_L 110_L 0.93 0.06
13_L 250_V 0.91 0.06
33_L 425_F 0.89 0.06
25_I 103_R 0.89 0.05
10_L 338_S 0.87 0.05
9_L 428_E 0.84 0.05
84_S 113_A 0.84 0.04
78_I 221_P 0.83 0.04
30_S 253_I 0.83 0.04
69_A 354_G 0.82 0.04
41_S 371_L 0.81 0.04
27_V 65_F 0.79 0.04
79_F 276_L 0.79 0.04
34_M 83_V 0.79 0.04
38_A 208_L 0.78 0.04
84_S 103_R 0.78 0.04
61_I 285_A 0.78 0.04
74_L 315_Y 0.78 0.04
84_S 269_A 0.77 0.04
9_L 581_L 0.77 0.04
13_L 389_L 0.77 0.04
16_Y 185_I 0.77 0.03
53_G 65_F 0.75 0.03
64_A 210_F 0.75 0.03
25_I 535_D 0.75 0.03
74_L 98_D 0.74 0.03
58_L 116_L 0.74 0.03
24_A 185_I 0.74 0.03
23_T 242_A 0.74 0.03
22_R 427_G 0.73 0.03
15_V 425_F 0.73 0.03
75_I 310_A 0.73 0.03
56_A 185_I 0.73 0.03
80_R 331_L 0.73 0.03
89_D 58_E 0.73 0.03
12_A 171_L 0.73 0.03
43_V 503_L 0.73 0.03
73_G 173_M 0.73 0.03
25_I 291_I 0.72 0.03
46_A 77_L 0.72 0.03
20_T 253_I 0.72 0.03
31_I 184_S 0.72 0.03
46_A 542_I 0.72 0.03
17_G 369_G 0.71 0.03
21_R 118_L 0.70 0.03
74_L 578_L 0.70 0.03
53_G 119_V 0.70 0.03
55_V 172_G 0.70 0.03
21_R 318_A 0.69 0.03
69_A 185_I 0.69 0.03
55_V 176_L 0.68 0.03
80_R 72_L 0.68 0.03
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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