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OPENSEQ.org

4HEA_J - 4HEA_N
UniProt: Q56225 - Q56229 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 603
Sequences: 1438
Seq/Len: 2.46
I_Prob: 1.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4he8IN:GM:FL:DJContact Map
4heaNV:MU:LT:JRContact Map
3rkoDN:CM:BL:FJContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
141_A 97_L 2.89 1.00
152_V 120_A 2.25 0.99
148_A 117_P 1.51 0.88
141_A 106_L 1.23 0.69
138_V 52_P 1.21 0.67
144_F 7_A 1.15 0.61
73_L 138_L 1.11 0.56
141_A 109_V 1.10 0.56
4_L 179_L 1.08 0.52
145_L 109_V 1.06 0.51
47_D 240_S 1.03 0.47
52_G 217_A 1.02 0.46
145_L 113_A 1.02 0.46
53_F 188_A 1.02 0.45
53_F 212_A 1.01 0.45
148_A 113_A 1.00 0.44
156_L 141_A 0.99 0.42
37_L 105_L 0.98 0.41
128_G 115_S 0.98 0.41
71_I 221_A 0.97 0.40
110_G 143_A 0.95 0.38
15_S 366_V 0.94 0.36
54_I 226_V 0.93 0.35
40_A 211_M 0.92 0.34
138_V 105_L 0.92 0.34
75_F 142_L 0.92 0.33
71_I 214_S 0.91 0.33
137_F 372_A 0.91 0.33
13_L 242_V 0.91 0.33
43_Y 266_A 0.90 0.32
19_V 220_F 0.90 0.32
71_I 246_L 0.90 0.32
43_Y 138_L 0.90 0.31
29_A 289_V 0.89 0.30
9_L 70_A 0.89 0.30
45_A 84_F 0.86 0.28
11_L 101_T 0.86 0.27
21_T 262_S 0.86 0.27
48_A 219_A 0.86 0.27
25_A 215_V 0.85 0.27
29_A 156_G 0.85 0.27
48_A 294_L 0.85 0.26
63_I 385_R 0.85 0.26
48_A 184_G 0.84 0.26
127_L 339_L 0.84 0.25
32_L 240_S 0.84 0.25
136_L 109_V 0.84 0.25
60_A 116_L 0.84 0.25
28_A 61_V 0.84 0.25
97_A 209_L 0.84 0.25
66_L 258_L 0.83 0.25
137_F 292_T 0.83 0.24
28_A 99_A 0.83 0.24
74_L 139_L 0.82 0.24
98_L 290_L 0.82 0.24
70_V 139_L 0.82 0.23
45_A 323_G 0.82 0.23
70_V 215_V 0.82 0.23
53_F 344_G 0.82 0.23
51_L 299_L 0.82 0.23
8_A 274_Y 0.81 0.23
65_V 174_L 0.81 0.22
63_I 142_L 0.81 0.22
63_I 419_V 0.80 0.22
143_G 123_T 0.80 0.21
28_A 133_A 0.80 0.21
56_V 121_L 0.79 0.21
107_G 177_G 0.79 0.21
19_V 57_G 0.79 0.20
142_V 109_V 0.79 0.20
40_A 294_L 0.79 0.20
144_F 90_Y 0.79 0.20
147_M 92_A 0.79 0.20
145_L 217_A 0.78 0.20
39_L 121_L 0.78 0.20
147_M 184_G 0.78 0.20
145_L 331_L 0.78 0.20
150_T 215_V 0.77 0.19
31_A 133_A 0.77 0.19
122_G 211_M 0.77 0.19
70_V 377_G 0.77 0.19
139_L 90_Y 0.77 0.19
9_L 210_F 0.77 0.19
68_L 271_L 0.77 0.19
58_V 93_L 0.77 0.18
68_L 367_T 0.77 0.18
105_A 403_V 0.76 0.18
27_H 323_G 0.76 0.18
143_G 66_A 0.76 0.18
15_S 97_L 0.76 0.18
14_L 243_V 0.76 0.18
68_L 369_A 0.76 0.18
4_L 142_L 0.76 0.18
60_A 152_A 0.76 0.18
32_L 195_W 0.76 0.18
61_G 185_F 0.75 0.17
14_L 363_L 0.75 0.17
138_V 245_N 0.75 0.17
115_F 328_V 0.75 0.17
121_G 160_S 0.75 0.17
14_L 407_V 0.75 0.17
156_L 119_Y 0.75 0.17
44_V 114_L 0.74 0.17
150_T 175_A 0.74 0.17
64_V 146_F 0.74 0.17
20_V 65_L 0.74 0.16
76_A 371_S 0.74 0.16
19_V 418_L 0.74 0.16
53_F 257_L 0.74 0.16
93_A 124_W 0.74 0.16
40_A 189_L 0.73 0.16
128_G 374_Y 0.73 0.16
31_A 379_G 0.73 0.16
73_L 266_A 0.73 0.16
29_A 103_H 0.73 0.15
133_G 119_Y 0.73 0.15
17_V 71_L 0.73 0.15
68_L 300_S 0.73 0.15
153_A 214_S 0.73 0.15
60_A 130_L 0.72 0.15
33_I 296_F 0.72 0.15
156_L 247_A 0.72 0.15
132_Y 139_L 0.72 0.15
49_R 74_V 0.72 0.15
17_V 121_L 0.72 0.15
52_G 291_A 0.72 0.15
47_D 188_A 0.72 0.15
17_V 129_G 0.72 0.15
44_V 6_L 0.72 0.15
85_P 269_M 0.71 0.14
36_F 367_T 0.71 0.14
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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