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OPENSEQ.org
4HEA_J - 4HEA_M
UniProt: Q56225 - Q56228 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 645
Sequences: 1455
Seq/Len: 2.34
I_Prob: 0.03
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaMU:LT:NV:JRContact Map
4he8GM:FL:IN:DJContact Map
3rkoCM:BL:DN:FJContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
71_I 412_K 1.18 0.03
58_V 187_E 1.07 0.02
11_L 95_F 0.96 0.02
141_A 443_M 0.94 0.02
33_I 285_L 0.93 0.01
13_L 26_V 0.92 0.01
152_V 86_A 0.92 0.01
37_L 115_L 0.91 0.01
80_E 107_L 0.90 0.01
141_A 109_L 0.90 0.01
94_A 342_G 0.90 0.01
96_L 304_T 0.89 0.01
56_V 316_A 0.88 0.01
98_L 8_L 0.87 0.01
26_I 208_F 0.87 0.01
43_Y 293_M 0.87 0.01
74_L 324_G 0.86 0.01
15_S 226_L 0.86 0.01
23_R 158_P 0.86 0.01
4_L 31_L 0.84 0.01
52_G 237_G 0.84 0.01
145_L 174_T 0.84 0.01
141_A 442_L 0.83 0.01
20_V 10_V 0.83 0.01
28_A 24_L 0.82 0.01
132_Y 276_F 0.82 0.01
135_W 436_S 0.80 0.01
3_L 266_L 0.80 0.01
54_I 440_L 0.80 0.01
66_L 300_V 0.79 0.01
128_G 286_A 0.79 0.01
56_V 431_G 0.79 0.01
58_V 312_L 0.78 0.01
65_V 381_L 0.78 0.01
144_F 406_A 0.78 0.01
43_Y 138_G 0.77 0.01
56_V 393_A 0.77 0.01
127_L 446_F 0.77 0.01
128_G 291_S 0.77 0.01
32_L 129_A 0.77 0.01
41_G 266_L 0.77 0.01
145_L 74_F 0.76 0.01
131_L 367_G 0.76 0.01
63_I 272_A 0.76 0.01
135_W 70_L 0.75 0.01
54_I 135_L 0.75 0.01
39_L 265_A 0.75 0.01
41_G 121_F 0.75 0.01
52_G 398_S 0.75 0.01
151_V 4_L 0.75 0.01
20_V 285_L 0.75 0.01
20_V 56_L 0.74 0.01
91_P 210_L 0.74 0.01
30_L 320_V 0.73 0.01
39_L 232_T 0.73 0.01
147_M 129_A 0.73 0.01
7_L 8_L 0.72 0.01
60_A 214_L 0.72 0.01
40_A 203_I 0.72 0.01
11_L 166_A 0.72 0.01
40_A 356_A 0.71 0.01
140_L 147_T 0.71 0.01
47_D 367_G 0.71 0.01
54_I 355_A 0.71 0.01
64_V 146_Y 0.71 0.01
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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