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OPENSEQ.org
4HEA_9 - 4HEA_A
UniProt: Q56224 - Q56217 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 301
Sequences: 1039
Seq/Len: 3.98
I_Prob: 0.03
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea9O:AP:3DContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
115_L 62_Y 1.05 0.03
117_Y 83_V 1.00 0.03
67_A 61_F 0.98 0.03
96_L 79_W 0.82 0.02
54_I 48_N 0.81 0.02
54_I 44_Y 0.79 0.01
110_T 46_S 0.79 0.01
76_D 88_L 0.79 0.01
34_K 57_F 0.78 0.01
94_N 63_V 0.78 0.01
127_S 31_L 0.78 0.01
52_K 48_N 0.77 0.01
129_L 78_L 0.76 0.01
38_H 37_G 0.76 0.01
69_Y 105_V 0.75 0.01
8_Q 12_I 0.74 0.01
70_V 57_F 0.73 0.01
95_M 27_V 0.73 0.01
18_F 86_G 0.72 0.01
103_L 61_F 0.72 0.01
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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