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OPENSEQ.org

4HEA_1 - 4HEA_N
UniProt: Q56222 - Q56229 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 865
Sequences: 1217
Seq/Len: 1.45
I_Prob: 0.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea1B:NV:MU:LTContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
410_V 370_V 0.92 0.00
173_V 292_T 0.91 0.00
192_L 263_I 0.87 0.00
394_I 353_A 0.85 0.00
90_I 257_L 0.84 0.00
121_A 372_A 0.84 0.00
330_L 254_A 0.84 0.00
223_T 311_A 0.82 0.00
268_M 161_L 0.81 0.00
192_L 217_A 0.77 0.00
302_F 344_G 0.77 0.00
225_A 282_G 0.76 0.00
171_L 161_L 0.76 0.00
327_G 368_S 0.74 0.00
268_M 183_L 0.74 0.00
320_G 105_L 0.72 0.00
227_V 209_L 0.72 0.00
150_K 166_P 0.72 0.00
223_T 107_M 0.71 0.00
57_V 356_G 0.71 0.00
372_A 103_H 0.70 0.00
318_A 404_A 0.70 0.00
327_G 128_Q 0.70 0.00
186_T 273_L 0.70 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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