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OPENSEQ.org

4HEA_1 - 4HEA_5
UniProt: Q56222 - Q56219 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 645
Sequences: 1104
Seq/Len: 1.98
I_Prob: 0.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3ias1SJA:5NEW:4DVMContact Map
3i9v1A:5E:4DContact Map
3m9s1A:5E:4DContact Map
2fug1SAJ:5NEW:4VMDContact Map
3iam1A:5E:4DContact Map
4hea1B:5F:4EContact Map
2ybb1:5:4Contact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
122_G 104_V 0.99 0.00
115_I 86_S 0.85 0.00
89_L 40_H 0.82 0.00
57_V 108_W 0.80 0.00
54_I 54_G 0.78 0.00
195_L 104_V 0.78 0.00
145_L 107_L 0.77 0.00
236_D 46_F 0.77 0.00
339_D 84_D 0.77 0.00
119_I 39_A 0.75 0.00
318_A 122_F 0.73 0.00
174_H 104_V 0.73 0.00
34_R 32_E 0.72 0.00
284_L 90_V 0.70 0.00
273_R 46_F 0.69 0.00
93_A 119_Y 0.68 0.00
118_M 88_F 0.67 0.00
149_I 109_G 0.67 0.00
235_A 106_D 0.66 0.00
236_D 107_L 0.66 0.00
270_T 56_D 0.66 0.00
59_R 104_V 0.65 0.00
260_R 37_E 0.65 0.00
330_L 94_V 0.65 0.00
74_L 135_I 0.65 0.00
251_L 104_V 0.64 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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