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OPENSEQ.org
4HEA_2 - 4HEA_J
UniProt: Q56221 - Q56225 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 357
Sequences: 1017
Seq/Len: 3.17
I_Prob: 0.15
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea2C:JRContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
105_G 149_A 1.22 0.15
154_L 56_V 1.11 0.11
79_H 29_A 0.99 0.07
156_G 102_G 0.93 0.06
135_Q 57_I 0.93 0.06
117_F 10_F 0.92 0.06
125_L 24_N 0.91 0.06
146_T 19_V 0.91 0.06
100_L 8_A 0.91 0.06
24_R 57_I 0.88 0.05
134_I 71_I 0.86 0.05
154_L 29_A 0.86 0.05
77_K 80_E 0.86 0.05
89_K 58_V 0.86 0.05
125_L 37_L 0.82 0.04
148_A 106_A 0.79 0.04
156_G 105_A 0.78 0.04
98_D 141_A 0.78 0.03
40_W 73_L 0.78 0.03
131_A 123_L 0.77 0.03
141_Y 149_A 0.77 0.03
153_L 34_L 0.75 0.03
78_Y 124_P 0.74 0.03
15_F 45_A 0.74 0.03
43_P 44_V 0.74 0.03
74_P 57_I 0.74 0.03
150_L 135_W 0.74 0.03
153_L 116_T 0.72 0.03
112_T 99_G 0.72 0.03
129_H 60_A 0.72 0.03
101_T 135_W 0.72 0.03
79_H 19_V 0.71 0.03
97_W 27_H 0.71 0.03
110_E 46_L 0.70 0.03
95_E 63_I 0.70 0.03
96_L 85_P 0.70 0.03
69_Y 100_V 0.70 0.03
154_L 105_A 0.69 0.02
85_T 155_A 0.69 0.02
80_L 54_I 0.69 0.02
126_G 150_T 0.69 0.02
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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