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OPENSEQ.org
4HEA_2 - 4HEA_4
UniProt: Q56221 - Q56220 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 590
Sequences: 1249
Seq/Len: 2.25
I_Prob: 0.01
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3i9v4D:2BContact Map
3ias4DVM:2TKBContact Map
2fug4VMD:2TKBContact Map
3m9s4D:2BContact Map
3iam4D:2BContact Map
4hea4E:2CContact Map
2ybb4:2Contact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
152_A 394_V 1.09 0.01
147_R 344_V 0.90 0.01
153_L 380_S 0.84 0.00
122_V 395_A 0.79 0.00
131_A 393_M 0.76 0.00
145_V 52_V 0.76 0.00
80_L 97_Y 0.74 0.00
93_A 75_Y 0.74 0.00
92_G 346_T 0.71 0.00
119_V 346_T 0.71 0.00
147_R 220_G 0.71 0.00
99_Y 266_L 0.67 0.00
153_L 389_Q 0.67 0.00
148_A 106_G 0.67 0.00
82_V 405_G 0.66 0.00
136_V 135_T 0.66 0.00
157_L 371_R 0.66 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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