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OPENSEQ.org
4HEA_4 - 4HEA_J
UniProt: Q56220 - Q56225 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 585
Sequences: 1103
Seq/Len: 2.01
I_Prob: 0.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea4E:JRContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
96_A 54_I 1.09 0.00
195_E 11_L 1.06 0.00
98_A 100_V 0.99 0.00
107_A 13_L 0.96 0.00
118_V 71_I 0.95 0.00
290_I 132_Y 0.95 0.00
133_L 71_I 0.93 0.00
220_G 56_V 0.92 0.00
369_K 68_L 0.88 0.00
106_G 10_F 0.88 0.00
201_I 37_L 0.86 0.00
168_F 150_T 0.84 0.00
387_G 48_A 0.84 0.00
399_S 37_L 0.82 0.00
366_Y 154_V 0.82 0.00
106_G 56_V 0.80 0.00
405_G 49_R 0.80 0.00
219_R 42_V 0.79 0.00
159_L 47_D 0.78 0.00
198_P 143_G 0.78 0.00
357_I 105_A 0.77 0.00
201_I 141_A 0.76 0.00
109_V 7_L 0.75 0.00
387_G 46_L 0.75 0.00
130_L 143_G 0.75 0.00
197_L 4_L 0.74 0.00
233_G 65_V 0.73 0.00
352_E 8_A 0.73 0.00
178_V 154_V 0.73 0.00
171_N 18_L 0.72 0.00
386_K 53_F 0.72 0.00
98_A 137_F 0.72 0.00
233_G 73_L 0.72 0.00
201_I 58_V 0.72 0.00
384_A 37_L 0.72 0.00
407_V 137_F 0.72 0.00
222_G 141_A 0.72 0.00
359_S 22_L 0.72 0.00
57_P 52_G 0.71 0.00
378_L 66_L 0.71 0.00
119_I 11_L 0.71 0.00
294_L 57_I 0.71 0.00
218_A 52_G 0.71 0.00
250_K 30_L 0.71 0.00
362_G 58_V 0.70 0.00
338_P 45_A 0.70 0.00
204_Y 143_G 0.70 0.00
399_S 158_E 0.70 0.00
291_K 56_V 0.70 0.00
137_L 149_A 0.70 0.00
370_V 24_N 0.70 0.00
355_Y 57_I 0.69 0.00
28_L 54_I 0.69 0.00
395_A 44_V 0.69 0.00
194_L 37_L 0.69 0.00
291_K 136_L 0.69 0.00
350_R 32_L 0.69 0.00
55_V 13_L 0.69 0.00
75_Y 40_A 0.69 0.00
369_K 41_G 0.69 0.00
336_H 141_A 0.69 0.00
288_K 125_Q 0.68 0.00
206_A 118_D 0.68 0.00
130_L 104_L 0.68 0.00
52_V 71_I 0.68 0.00
97_Y 76_A 0.68 0.00
149_A 33_I 0.68 0.00
124_S 43_Y 0.68 0.00
278_V 16_G 0.68 0.00
396_I 74_L 0.68 0.00
53_L 151_V 0.68 0.00
369_K 154_V 0.68 0.00
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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