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OPENSEQ.org
4HEA_4 - 4HEA_6
UniProt: Q56220 - Q56218 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 590
Sequences: 1850
Seq/Len: 3.43
I_Prob: 0.79
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3i9v4D:6FContact Map
3ias4DVM:6FOXContact Map
2fug4VMD:6FOXContact Map
3m9s4D:6FContact Map
4hea4E:6GContact Map
3iam4D:6FContact Map
2ybb4:6Contact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
69_T 120_N 1.51 0.79
64_T 83_R 1.13 0.45
161_E 143_R 1.04 0.36
147_F 56_A 0.96 0.28
158_D 57_R 0.96 0.28
146_F 55_D 0.96 0.28
382_P 148_I 0.95 0.28
81_Y 117_M 0.91 0.24
346_T 130_V 0.88 0.22
63_H 121_Y 0.88 0.21
146_F 51_M 0.87 0.20
126_L 101_D 0.86 0.20
66_F 118_F 0.84 0.19
182_L 113_S 0.84 0.19
73_R 119_N 0.82 0.17
64_T 110_A 0.81 0.17
65_G 122_A 0.81 0.16
362_G 135_V 0.80 0.16
251_A 137_V 0.78 0.15
65_G 120_N 0.74 0.12
265_P 84_L 0.74 0.12
33_Q 95_V 0.72 0.11
123_L 103_K 0.71 0.11
212_P 103_K 0.70 0.10
249_R 103_K 0.70 0.10
69_T 114_S 0.70 0.10
355_Y 52_A 0.68 0.09
400_L 56_A 0.68 0.09
151_R 50_M 0.68 0.09
62_L 84_L 0.67 0.09
62_L 44_A 0.67 0.09
407_V 70_A 0.67 0.08
134_G 146_A 0.66 0.08
84_R 111_C 0.65 0.08
349_A 65_S 0.65 0.08
182_L 92_M 0.64 0.07
42_R 124_V 0.64 0.07
198_P 85_S 0.64 0.07
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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