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OPENSEQ.org
4HEA_5 - 4HEA_K
UniProt: Q56219 - Q56226 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 302
Sequences: 1347
Seq/Len: 5.78
I_Prob: 0.15
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea5F:KS:4E:JRContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
88_F 37_A 1.14 0.15
70_V 40_L 0.89 0.07
49_L 34_M 0.89 0.07
136_L 46_A 0.87 0.07
122_F 79_F 0.82 0.05
31_R 5_L 0.81 0.05
106_D 5_L 0.79 0.05
98_D 13_L 0.78 0.05
141_L 29_L 0.78 0.05
37_E 30_S 0.77 0.04
107_L 43_V 0.77 0.04
138_P 36_N 0.76 0.04
27_V 43_V 0.76 0.04
56_D 61_I 0.73 0.04
45_G 90_L 0.72 0.04
109_G 63_V 0.72 0.04
48_F 30_S 0.71 0.04
132_L 74_L 0.71 0.04
136_L 61_I 0.71 0.04
111_A 48_A 0.70 0.03
108_W 77_A 0.70 0.03
36_E 12_A 0.69 0.03
140_D 36_N 0.69 0.03
38_M 60_V 0.69 0.03
140_D 61_I 0.69 0.03
74_L 57_A 0.69 0.03
142_E 93_L 0.68 0.03
49_L 48_A 0.68 0.03
124_I 85_T 0.67 0.03
105_T 73_G 0.67 0.03
109_G 40_L 0.67 0.03
121_L 84_S 0.67 0.03
132_L 55_V 0.67 0.03
130_P 29_L 0.66 0.03
150_Y 80_R 0.66 0.03
99_P 16_Y 0.66 0.03
119_Y 72_L 0.66 0.03
92_V 40_L 0.66 0.03
54_G 10_L 0.65 0.03
31_R 90_L 0.65 0.03
127_E 42_L 0.64 0.03
97_E 84_S 0.64 0.03
47_N 78_I 0.64 0.03
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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