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OPENSEQ.org
4HEA_5 - 4HEA_J
UniProt: Q56219 - Q56225 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 383
Sequences: 1312
Seq/Len: 4.37
I_Prob: 0.85
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4hea5F:JR:4EContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
101_L 151_V 1.53 0.85
40_H 63_I 1.29 0.70
108_W 36_F 1.09 0.50
113_F 132_Y 1.03 0.44
107_L 136_L 1.01 0.42
27_V 13_L 0.99 0.39
70_V 57_I 0.94 0.33
36_E 141_A 0.89 0.28
106_D 56_V 0.89 0.28
113_F 29_A 0.88 0.28
97_E 22_L 0.88 0.28
119_Y 125_Q 0.88 0.28
36_E 23_R 0.88 0.28
50_A 20_V 0.86 0.26
109_G 56_V 0.86 0.26
39_A 102_G 0.85 0.25
114_L 67_F 0.85 0.25
132_L 20_V 0.85 0.24
50_A 19_V 0.84 0.24
40_H 3_L 0.84 0.24
72_Y 101_A 0.83 0.23
101_L 16_G 0.82 0.22
30_P 112_D 0.82 0.22
46_F 155_A 0.82 0.22
67_R 70_V 0.81 0.21
87_R 67_F 0.81 0.21
150_Y 132_Y 0.81 0.21
97_E 45_A 0.80 0.21
110_S 57_I 0.80 0.21
107_L 156_L 0.78 0.19
91_R 4_L 0.78 0.19
71_V 52_G 0.77 0.18
110_S 66_L 0.77 0.18
73_E 143_G 0.76 0.17
95_P 28_A 0.76 0.17
54_G 135_W 0.75 0.17
125_V 56_V 0.75 0.16
34_F 47_D 0.75 0.16
103_T 143_G 0.75 0.16
124_I 119_L 0.74 0.16
54_G 137_F 0.74 0.16
128_G 41_G 0.74 0.16
75_V 73_L 0.73 0.15
142_E 57_I 0.73 0.15
106_D 13_L 0.73 0.15
32_E 116_T 0.73 0.15
122_F 45_A 0.73 0.15
127_E 7_L 0.73 0.15
136_L 72_M 0.73 0.15
138_P 64_V 0.73 0.15
138_P 55_Q 0.73 0.15
73_E 144_F 0.72 0.15
98_D 88_R 0.72 0.14
106_D 116_T 0.72 0.14
146_L 43_Y 0.71 0.14
146_L 140_L 0.70 0.14
105_T 56_V 0.70 0.14
30_P 10_F 0.70 0.13
150_Y 43_Y 0.70 0.13
132_L 100_V 0.70 0.13
40_H 17_V 0.70 0.13
141_L 158_E 0.70 0.13
70_V 17_V 0.70 0.13
113_F 157_V 0.70 0.13
110_S 73_L 0.69 0.13
98_D 56_V 0.69 0.13
27_V 21_T 0.69 0.12
93_Y 26_I 0.69 0.12
107_L 149_A 0.69 0.12
108_W 12_L 0.68 0.12
107_L 147_M 0.68 0.12
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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