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OPENSEQ.org
4HEA_A - 4HEA_H
UniProt: Q56217 - Q60019 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 484
Sequences: 2821
Seq/Len: 6.61
I_Prob: 1.00
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
4heaHQ:APContact Map
4he8CH:ABContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
40_K 70_E 2.86 1.00
52_G 146_K 1.89 0.98
54_V 144_G 1.74 0.97
97_L 322_L 1.59 0.95
21_G 87_L 1.47 0.92
18_L 91_V 1.47 0.92
18_L 87_L 1.43 0.91
25_L 87_L 1.36 0.88
41_L 72_I 1.34 0.87
54_V 78_D 1.21 0.80
44_Y 222_P 1.19 0.79
67_L 63_A 1.19 0.78
111_W 311_G 1.13 0.73
28_G 239_I 1.13 0.73
79_W 180_L 1.09 0.69
75_V 167_G 1.02 0.62
14_V 95_L 0.99 0.59
22_V 87_L 0.94 0.53
46_S 141_W 0.94 0.53
43_P 232_Y 0.94 0.52
117_R 311_G 0.94 0.52
101_L 257_A 0.92 0.50
108_L 319_L 0.92 0.49
28_G 238_S 0.91 0.48
93_F 322_L 0.91 0.48
96_V 171_L 0.90 0.47
61_F 228_L 0.88 0.45
21_G 246_M 0.88 0.45
29_A 71_D 0.87 0.44
43_P 145_S 0.87 0.43
55_K 153_L 0.86 0.42
100_T 321_F 0.86 0.42
79_W 40_A 0.84 0.40
27_V 197_L 0.84 0.39
25_L 266_G 0.84 0.39
100_T 318_L 0.83 0.39
106_G 212_A 0.83 0.39
23_A 22_V 0.82 0.37
53_E 149_L 0.82 0.37
44_Y 242_A 0.82 0.37
51_A 122_I 0.82 0.37
63_V 49_N 0.81 0.36
76_A 131_L 0.80 0.35
35_K 85_A 0.80 0.35
84_S 260_P 0.80 0.34
46_S 37_R 0.80 0.34
67_L 176_L 0.80 0.34
38_R 322_L 0.79 0.34
48_N 233_H 0.79 0.33
99_F 199_A 0.79 0.33
22_V 191_E 0.79 0.33
97_L 15_L 0.78 0.33
69_I 243_L 0.78 0.33
62_Y 222_P 0.78 0.33
65_A 74_V 0.78 0.32
99_F 309_G 0.77 0.31
69_I 43_Q 0.77 0.31
73_V 309_G 0.77 0.30
100_T 167_G 0.76 0.30
75_V 164_L 0.75 0.29
99_F 219_F 0.75 0.29
118_W 306_L 0.75 0.29
25_L 83_V 0.75 0.28
41_L 75_A 0.75 0.28
30_L 73_V 0.75 0.28
112_W 122_I 0.75 0.28
101_L 95_L 0.74 0.28
101_L 98_G 0.74 0.28
27_V 160_I 0.74 0.28
100_T 322_L 0.74 0.27
44_Y 317_A 0.73 0.27
100_T 168_L 0.73 0.26
25_L 283_I 0.73 0.26
105_V 156_S 0.72 0.26
44_Y 159_L 0.72 0.26
20_I 153_L 0.72 0.25
82_A 175_L 0.71 0.25
19_F 183_N 0.71 0.25
30_L 67_I 0.71 0.24
70_L 56_L 0.71 0.24
110_E 302_Y 0.71 0.24
49_D 242_A 0.71 0.24
97_L 260_P 0.70 0.24
109_Y 178_G 0.70 0.24
102_L 173_P 0.70 0.23
113_K 300_L 0.70 0.23
83_V 321_F 0.69 0.23
22_V 17_A 0.69 0.23
60_H 247_A 0.69 0.23
26_L 105_P 0.69 0.22
67_L 244_F 0.69 0.22
58_P 302_Y 0.69 0.22
79_W 171_L 0.69 0.22
84_S 131_L 0.69 0.22
115_V 292_W 0.69 0.22
18_L 95_L 0.68 0.22
104_F 128_V 0.68 0.22
41_L 63_A 0.68 0.22
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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