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OPENSEQ.org
4HEA_A - 4HEA_L
UniProt: Q56217 - Q56227 Query Sequences:

 Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 725
Sequences: 3425
Seq/Len: 4.82
I_Prob: 0.21
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3rkoBL:CM:DN:AEContact Map
4heaLT:MU:NV:APContact Map
4he8FL:GM:IN:ABContact Map


 Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
99_F 160_I 1.18 0.21
28_G 425_F 1.13 0.18
85_A 211_L 1.10 0.17
69_I 260_Y 1.01 0.12
97_L 160_I 0.99 0.12
105_V 180_Y 0.97 0.11
38_R 110_L 0.97 0.11
99_F 320_F 0.96 0.11
25_L 473_L 0.95 0.10
28_G 380_S 0.94 0.10
67_L 280_Y 0.94 0.10
107_F 227_P 0.94 0.10
115_V 453_S 0.93 0.09
109_Y 159_F 0.92 0.09
20_I 147_K 0.90 0.09
18_L 473_L 0.90 0.09
23_A 455_L 0.89 0.08
118_W 375_G 0.89 0.08
80_P 303_L 0.88 0.08
106_G 450_A 0.88 0.08
50_P 379_L 0.87 0.08
115_V 327_F 0.87 0.08
19_F 113_A 0.87 0.08
99_F 427_G 0.87 0.08
101_L 572_R 0.86 0.07
99_F 441_V 0.85 0.07
67_L 334_L 0.84 0.07
28_G 118_L 0.84 0.07
78_L 330_A 0.84 0.07
26_L 408_L 0.83 0.07
57_F 183_L 0.83 0.07
115_V 274_G 0.83 0.07
70_L 310_A 0.83 0.07
23_A 551_E 0.83 0.07
76_A 90_Y 0.83 0.07
29_A 505_L 0.83 0.07
57_F 184_S 0.82 0.06
100_T 582_Q 0.82 0.06
69_I 327_F 0.81 0.06
108_L 183_L 0.80 0.06
99_F 71_N 0.80 0.06
76_A 365_H 0.79 0.06
22_V 499_A 0.79 0.06
62_Y 327_F 0.79 0.06
102_L 421_F 0.78 0.06
98_A 572_R 0.78 0.05
22_V 97_G 0.77 0.05
97_L 124_Y 0.77 0.05
86_G 502_L 0.77 0.05
117_R 92_I 0.77 0.05
69_I 371_L 0.76 0.05
38_R 71_N 0.76 0.05
22_V 507_A 0.76 0.05
109_Y 334_L 0.75 0.05
100_T 257_S 0.75 0.05
49_D 90_Y 0.75 0.05
61_F 170_M 0.75 0.05
30_L 394_T 0.75 0.05
78_L 145_W 0.75 0.05
57_F 227_P 0.74 0.05
18_L 451_L 0.74 0.05
28_G 426_L 0.74 0.05
29_A 318_A 0.74 0.05
100_T 505_L 0.73 0.04
59_V 169_F 0.73 0.04
77_F 251_Y 0.73 0.04
26_L 473_L 0.73 0.04
101_L 573_S 0.73 0.04
70_L 327_F 0.73 0.04
58_P 90_Y 0.72 0.04
80_P 162_N 0.71 0.04
40_K 413_T 0.71 0.04
40_K 302_Q 0.71 0.04
98_A 176_L 0.71 0.04
78_L 504_G 0.71 0.04
98_A 500_V 0.71 0.04
98_A 113_A 0.71 0.04
18_L 210_F 0.71 0.04
28_G 456_A 0.71 0.04
105_V 198_N 0.70 0.04
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions (includes both intra and inter preds)
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