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OPENSEQ.org

4HEA_A - 4HEA_J
UniProt: Q56217 - Q56225 Query Sequences:

Download Alignment
We filter this alignment to remove positions that have > 75% gaps before running GREMLIN.
Length: 295
Sequences: 1356
Seq/Len: 4.89
I_Prob: 0.99
GREMLIN Results (Scaled_score > 1):

Legend: The darker and larger the blue dots, the higher strength in coevolution. Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on HHsearch results which uses the overall probability and per-site alignment confidence. Inter-chain contacts in the pdb are in shades of red.
3rkoAE:FJContact Map
4heaJR:APContact Map
4he8DJ:ABContact Map


Residue pairs sorted by strength in coevolution signal:
i j Scaled Score I_Prob
87_G 125_Q 2.25 0.99
95_G 143_G 2.04 0.99
110_E 154_V 1.89 0.98
102_L 143_G 1.59 0.94
91_Y 136_L 1.54 0.93
110_E 143_G 1.44 0.90
104_F 57_I 1.43 0.90
116_M 152_V 1.36 0.87
7_Y 49_R 1.31 0.85
84_S 129_P 1.30 0.84
76_A 29_A 1.22 0.78
106_G 147_M 1.20 0.77
58_P 25_A 1.19 0.76
106_G 150_T 1.18 0.76
54_V 33_I 1.17 0.74
59_V 68_L 1.16 0.74
110_E 140_L 1.12 0.70
95_G 140_L 1.12 0.70
83_V 99_G 1.12 0.70
84_S 125_Q 1.10 0.68
87_G 151_V 1.09 0.67
67_L 32_L 1.08 0.66
26_L 92_L 1.06 0.64
101_L 10_F 1.06 0.64
65_A 56_V 1.05 0.63
75_V 46_L 1.05 0.62
17_A 43_Y 1.04 0.61
87_G 95_L 1.03 0.61
31_L 101_A 1.03 0.61
19_F 71_I 1.03 0.61
76_A 57_I 1.03 0.60
82_A 140_L 1.00 0.57
24_A 54_I 1.00 0.57
69_I 27_H 0.99 0.56
96_V 139_L 0.99 0.56
28_G 152_V 0.98 0.55
24_A 57_I 0.98 0.54
105_V 117_Q 0.97 0.54
68_F 69_F 0.96 0.52
22_V 92_L 0.96 0.52
76_A 54_I 0.95 0.51
28_G 49_R 0.95 0.51
64_V 70_V 0.95 0.51
115_V 20_V 0.95 0.51
58_P 76_A 0.95 0.51
89_G 140_L 0.94 0.50
85_A 153_A 0.94 0.49
80_P 128_G 0.93 0.48
110_E 150_T 0.91 0.46
114_G 20_V 0.91 0.45
61_F 57_I 0.90 0.45
103_L 69_F 0.90 0.44
103_L 146_L 0.89 0.43
66_M 64_V 0.89 0.43
83_V 128_G 0.89 0.43
19_F 120_K 0.89 0.43
75_V 58_V 0.88 0.42
111_W 19_V 0.88 0.42
37_G 38_V 0.88 0.42
95_G 136_L 0.87 0.41
101_L 56_V 0.86 0.40
94_L 14_L 0.86 0.39
45_E 61_G 0.85 0.39
102_L 150_T 0.85 0.38
22_V 40_A 0.84 0.37
44_Y 42_V 0.84 0.37
44_Y 55_Q 0.84 0.37
85_A 73_L 0.84 0.37
18_L 102_G 0.84 0.37
65_A 61_G 0.84 0.37
35_K 4_L 0.83 0.36
56_R 75_F 0.83 0.36
43_P 32_L 0.83 0.36
93_F 22_L 0.83 0.36
19_F 46_L 0.83 0.36
26_L 116_T 0.83 0.35
33_P 43_Y 0.82 0.35
46_S 63_I 0.82 0.35
31_L 39_L 0.82 0.34
94_L 143_G 0.82 0.34
31_L 118_D 0.82 0.34
69_I 75_F 0.82 0.34
40_K 61_G 0.81 0.34
89_G 127_L 0.81 0.33
54_V 25_A 0.81 0.33
65_A 51_L 0.80 0.32
29_A 18_L 0.80 0.32
28_G 50_F 0.80 0.32
30_L 17_V 0.80 0.32
64_V 130_L 0.80 0.32
27_V 110_G 0.79 0.31
87_G 129_P 0.79 0.31
25_L 139_L 0.79 0.31
113_K 154_V 0.79 0.31
45_E 59_Y 0.79 0.31
34_K 37_L 0.79 0.31
80_P 138_V 0.78 0.30
66_M 45_A 0.78 0.30
109_Y 12_L 0.78 0.30
92_G 42_V 0.78 0.30
31_L 73_L 0.78 0.30
45_E 62_A 0.78 0.29
113_K 128_G 0.77 0.29
73_V 60_A 0.77 0.29
67_L 150_T 0.77 0.29
56_R 73_L 0.77 0.29
109_Y 51_L 0.76 0.28
31_L 93_A 0.76 0.28
26_L 119_L 0.76 0.28
86_G 129_P 0.76 0.28
68_F 61_G 0.76 0.28
117_R 42_V 0.76 0.27
117_R 40_A 0.76 0.27
88_L 36_F 0.75 0.27
97_L 104_L 0.75 0.27
62_Y 77_A 0.75 0.27
25_L 141_A 0.75 0.27
109_Y 19_V 0.75 0.26
72_D 62_A 0.74 0.26
Legend: The i (protein A) and j (protein B) are positions as given in the UniProt sequences. The value of the raw score is the function of the learning procedure, L2 normalization and APC (entropic) correction.

Scaled Score = raw_score/average(raw_scores)
I_Prob = P(contact | scaled_score, seq/len, top_inter_score)

Text file of predictions
(includes both intra and inter preds)

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