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OPENSEQ.org
YAIP - Uncharacterized protein YaiP
UniProt: Q47536 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13298
Length: 398 (354)
Sequences: 679
Seq/Len: 1.92
YAIP
Paralog alert: 0.23 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
56_P 134_A 3.284 1.00
42_G 71_N 3.107 1.00
76_M 89_A 2.865 1.00
33_D 110_C 2.461 1.00
71_N 74_A 2.318 1.00
83_W 86_R 2.271 1.00
254_G 257_V 2.235 1.00
35_I 64_V 2.231 1.00
139_G 228_A 2.202 1.00
105_L 113_V 2.174 0.99
33_D 60_R 2.167 0.99
46_A 78_E 2.154 0.99
33_D 108_A 2.135 0.99
125_D 135_E 2.124 0.99
32_I 133_L 2.114 0.99
45_L 72_T 2.009 0.99
60_R 108_A 1.922 0.98
66_D 96_G 1.9 0.98
143_V 226_R 1.888 0.98
60_R 88_V 1.856 0.98
76_M 87_F 1.851 0.98
195_T 199_R 1.779 0.97
38_A 72_T 1.764 0.97
46_A 79_V 1.757 0.97
36_I 63_C 1.726 0.96
326_A 335_V 1.685 0.96
77_A 91_T 1.617 0.94
97_K 250_R 1.603 0.94
145_G 225_I 1.597 0.94
39_Y 94_N 1.595 0.94
73_E 77_A 1.569 0.93
60_R 110_C 1.538 0.92
197_V 218_L 1.523 0.91
207_T 254_G 1.52 0.91
65_N 68_S 1.519 0.91
119_D 251_W 1.518 0.91
247_R 251_W 1.513 0.91
38_A 45_L 1.512 0.91
200_K 221_N 1.505 0.91
67_G 94_N 1.505 0.91
114_F 192_M 1.495 0.90
207_T 257_V 1.487 0.90
52_L 61_V 1.47 0.89
135_E 230_R 1.447 0.88
36_I 52_L 1.431 0.88
32_I 137_E 1.418 0.87
220_A 264_R 1.411 0.87
45_L 76_M 1.358 0.84
140_A 194_R 1.348 0.83
34_A 114_F 1.345 0.83
210_E 247_R 1.343 0.83
266_L 312_L 1.34 0.82
136_I 192_M 1.339 0.82
140_A 192_M 1.313 0.81
115_L 198_L 1.302 0.80
34_A 69_T 1.301 0.80
39_Y 67_G 1.297 0.80
37_P 193_F 1.293 0.79
108_A 195_T 1.291 0.79
250_R 254_G 1.291 0.79
112_Q 137_E 1.285 0.79
16_W 23_R 1.278 0.78
168_M 189_A 1.274 0.78
113_V 195_T 1.272 0.78
97_K 248_W 1.262 0.77
119_D 235_P 1.261 0.77
121_Y 196_D 1.26 0.77
325_S 338_A 1.258 0.77
197_V 223_Y 1.256 0.76
368_R 371_P 1.25 0.76
30_G 137_E 1.25 0.76
31_C 110_C 1.238 0.75
33_D 195_T 1.237 0.75
75_V 242_R 1.236 0.75
320_V 323_A 1.235 0.75
66_D 119_D 1.234 0.75
40_N 68_S 1.234 0.75
351_I 354_I 1.233 0.75
142_A 224_R 1.225 0.74
48_S 116_S 1.223 0.74
64_V 104_G 1.208 0.72
119_D 247_R 1.205 0.72
73_E 91_T 1.205 0.72
134_A 137_E 1.198 0.71
46_A 75_V 1.195 0.71
190_C 233_V 1.186 0.70
65_N 91_T 1.186 0.70
194_R 223_Y 1.185 0.70
248_W 251_W 1.177 0.70
151_L 189_A 1.171 0.69
19_S 23_R 1.17 0.69
193_F 218_L 1.17 0.69
50_D 82_K 1.169 0.69
46_A 50_D 1.167 0.69
119_D 210_E 1.164 0.68
291_T 321_I 1.161 0.68
148_S 231_C 1.157 0.68
116_S 122_V 1.146 0.67
58_F 134_A 1.146 0.67
194_R 201_F 1.145 0.66
50_D 54_R 1.142 0.66
120_T 235_P 1.141 0.66
124_P 134_A 1.141 0.66
186_I 191_G 1.14 0.66
172_K 235_P 1.14 0.66
198_L 251_W 1.139 0.66
208_K 250_R 1.138 0.66
362_T 369_D 1.138 0.66
199_R 221_N 1.135 0.65
147_P 209_V 1.132 0.65
355_Y 362_T 1.132 0.65
15_L 19_S 1.13 0.65
235_P 251_W 1.128 0.65
77_A 354_I 1.127 0.65
151_L 187_S 1.12 0.64
57_Y 137_E 1.117 0.64
210_E 254_G 1.114 0.63
119_D 209_V 1.101 0.62
64_V 100_A 1.091 0.61
113_V 194_R 1.091 0.61
74_A 78_E 1.088 0.61
136_I 231_C 1.087 0.61
34_A 52_L 1.086 0.60
114_F 234_Y 1.085 0.60
14_L 24_K 1.078 0.60
192_M 231_C 1.075 0.59
66_D 94_N 1.075 0.59
133_L 282_V 1.074 0.59
63_C 325_S 1.074 0.59
21_L 24_K 1.072 0.59
98_G 213_D 1.069 0.59
94_N 168_M 1.069 0.59
368_R 373_R 1.066 0.58
48_S 247_R 1.063 0.58
190_C 209_V 1.055 0.57
68_S 76_M 1.054 0.57
20_T 24_K 1.054 0.57
16_W 19_S 1.053 0.57
75_V 79_V 1.049 0.56
16_W 22_R 1.048 0.56
146_I 194_R 1.047 0.56
201_F 218_L 1.046 0.56
105_L 334_L 1.035 0.55
210_E 251_W 1.034 0.55
230_R 282_V 1.034 0.55
187_S 209_V 1.032 0.55
44_C 118_A 1.031 0.54
208_K 257_V 1.026 0.54
95_T 99_G 1.022 0.54
224_R 321_I 1.021 0.53
55_N 133_L 1.019 0.53
61_V 84_G 1.019 0.53
45_L 63_C 1.018 0.53
114_F 231_C 1.014 0.53
253_V 356_G 1.014 0.53
370_K 373_R 1.012 0.52
188_G 250_R 1.012 0.52
67_G 92_Q 1.012 0.52
312_L 319_C 1.011 0.52
16_W 21_L 1.01 0.52
97_K 251_W 1.007 0.52
51_N 121_Y 1.005 0.52
16_W 24_K 1.005 0.52
227_Q 257_V 1.002 0.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4hg6A10.94221000.562Contact Map0.394
2z86A40.67841000.664Contact Map0.633
2bo4A60.84671000.675Contact Map0.308
3bcvA20.54521000.677Contact Map0.674
1qg8A10.56531000.683Contact Map0.631
4fixA20.83171000.687Contact Map0.526
3l7iA40.88441000.69Contact Map0.331
2d7iA10.89951000.692Contact Map0.534
3ckjA10.7061000.697Contact Map0.496
1xhbA10.8971000.7Contact Map0.523
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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