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OPENSEQ.org
YQJH - NADPH-dependent ferric-chelate reductase
UniProt: Q46871 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12953
Length: 254 (240)
Sequences: 997
Seq/Len: 4.15
YQJH
Paralog alert: 0.19 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
146_C 154_L 4.813 1.00
27_R 33_Q 4.02 1.00
36_V 100_A 3.37 1.00
24_R 98_E 3.16 1.00
54_S 101_I 3.085 1.00
23_L 38_G 2.71 1.00
146_C 150_G 2.694 1.00
219_I 235_F 2.591 1.00
93_D 96_R 2.519 1.00
208_A 237_A 2.295 1.00
103_F 111_A 2.287 1.00
21_T 123_K 2.27 1.00
32_F 183_D 2.221 1.00
93_D 100_A 2.169 1.00
25_V 35_I 2.099 1.00
91_L 159_E 2.079 1.00
170_V 188_L 2.059 1.00
216_D 244_R 2.059 1.00
34_R 102_D 2.041 1.00
171_S 192_N 2.01 1.00
55_K 87_D 2.005 1.00
119_Q 122_D 1.977 1.00
25_V 33_Q 1.958 1.00
170_V 191_F 1.916 1.00
171_S 194_E 1.855 1.00
141_Y 217_Y 1.853 1.00
170_V 190_G 1.848 1.00
148_E 197_A 1.797 1.00
221_I 231_L 1.789 1.00
31_G 181_C 1.778 0.99
19_E 123_K 1.776 0.99
154_L 174_V 1.754 0.99
26_E 100_A 1.749 0.99
33_Q 105_I 1.747 0.99
140_A 215_D 1.735 0.99
36_V 98_E 1.721 0.99
24_R 36_V 1.627 0.99
20_L 37_L 1.61 0.99
93_D 98_E 1.605 0.99
158_L 172_A 1.601 0.99
118_A 122_D 1.588 0.99
234_R 238_E 1.563 0.98
141_Y 213_P 1.562 0.98
37_L 101_I 1.558 0.98
173_L 210_M 1.532 0.98
225_G 249_A 1.53 0.98
141_Y 215_D 1.53 0.98
175_S 197_A 1.524 0.98
187_H 190_G 1.502 0.98
39_G 42_L 1.49 0.98
164_L 170_V 1.474 0.97
145_V 207_L 1.471 0.97
196_L 202_A 1.467 0.97
170_V 187_H 1.45 0.97
155_R 185_L 1.45 0.97
249_A 252_H 1.438 0.97
221_I 228_V 1.429 0.97
20_L 126_V 1.399 0.96
173_L 194_E 1.399 0.96
207_L 231_L 1.394 0.96
105_I 116_M 1.385 0.96
90_P 99_L 1.376 0.96
231_L 235_F 1.37 0.96
176_V 182_Q 1.37 0.96
56_L 101_I 1.368 0.95
91_L 155_R 1.357 0.95
141_Y 171_S 1.35 0.95
136_P 218_F 1.331 0.95
36_V 93_D 1.294 0.93
23_L 98_E 1.28 0.93
29_S 183_D 1.277 0.93
223_G 228_V 1.271 0.93
221_I 235_F 1.257 0.92
29_S 32_F 1.254 0.92
37_L 126_V 1.207 0.90
234_R 237_A 1.2 0.89
58_F 85_S 1.193 0.89
53_H 87_D 1.191 0.89
166_V 189_D 1.186 0.89
201_Q 205_A 1.185 0.89
154_L 172_A 1.176 0.88
173_L 206_R 1.162 0.87
87_D 130_R 1.127 0.85
55_K 128_G 1.12 0.85
43_D 97_H 1.11 0.84
22_V 25_V 1.091 0.82
167_K 187_H 1.085 0.82
71_T 74_G 1.084 0.82
143_L 219_I 1.07 0.81
149_S 223_G 1.057 0.80
223_G 227_V 1.054 0.79
182_Q 195_W 1.049 0.79
22_V 35_I 1.049 0.79
113_G 116_M 1.042 0.78
164_L 168_P 1.036 0.78
102_D 183_D 1.029 0.77
150_G 154_L 1.022 0.76
143_L 207_L 1.018 0.76
117_Q 122_D 1.008 0.75
179_N 182_Q 1.008 0.75
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2gpjA10.86611000.576Contact Map0.799
2qdxA10.842599.90.648Contact Map0.706
1tvcA10.866199.90.651Contact Map0.507
2bgiA10.893799.90.656Contact Map0.722
4b4dA10.862299.90.659Contact Map0.692
3vo2A20.913499.90.66Contact Map0.637
2r6hA40.93799.90.661Contact Map0.63
2eixA20.866199.90.663Contact Map0.663
4fk8A20.893799.90.667Contact Map0.684
2piaA10.846599.90.668Contact Map0.661
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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