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OPENSEQ.org
YGHU - Disulfide-bond oxidoreductase YghU
UniProt: Q46845 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13005
Length: 288 (286)
Sequences: 300
Seq/Len: 1.05
YGHU
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
200_V 212_I 5.495 1.00
156_F 179_F 5.355 1.00
232_D 235_S 4.504 1.00
198_K 245_E 4.102 1.00
172_I 175_A 3.911 1.00
45_L 62_L 3.659 1.00
120_S 145_N 3.541 1.00
193_Q 200_V 3.471 1.00
173_E 177_N 3.33 1.00
109_H 113_I 3.106 1.00
30_S 192_K 3.103 1.00
221_L 244_K 2.842 1.00
29_V 33_T 2.714 1.00
56_Q 60_I 2.662 1.00
223_G 247_G 2.556 0.99
141_T 145_N 2.442 0.99
132_F 210_M 2.387 0.99
114_R 142_E 2.379 0.99
11_V 232_D 2.252 0.98
269_L 278_F 2.2 0.98
282_T 285_K 2.048 0.97
193_Q 197_H 2.023 0.96
191_D 238_H 1.972 0.95
143_T 206_T 1.961 0.95
241_R 245_E 1.931 0.95
15_D 177_N 1.893 0.94
42_K 274_D 1.892 0.94
191_D 237_K 1.846 0.93
220_V 240_Q 1.785 0.91
70_V 131_Y 1.745 0.90
136_D 139_K 1.726 0.89
220_V 228_A 1.722 0.89
157_L 183_A 1.665 0.87
14_W 29_V 1.647 0.86
109_H 124_Y 1.612 0.84
137_L 141_T 1.603 0.84
81_R 84_D 1.586 0.83
10_K 229_E 1.573 0.82
67_A 279_E 1.521 0.79
170_V 175_A 1.515 0.79
124_Y 137_L 1.514 0.79
186_L 216_F 1.512 0.79
172_I 179_F 1.506 0.78
264_P 267_E 1.48 0.77
14_W 33_T 1.476 0.76
115_V 141_T 1.455 0.75
5_T 170_V 1.432 0.73
180_T 233_A 1.417 0.72
29_V 35_E 1.415 0.72
280_T 284_D 1.413 0.72
51_G 246_V 1.412 0.72
32_P 192_K 1.406 0.71
45_L 124_Y 1.404 0.71
270_H 282_T 1.398 0.71
257_I 278_F 1.387 0.70
61_M 132_F 1.328 0.65
156_F 200_V 1.323 0.65
224_V 233_A 1.309 0.63
189_V 239_V 1.299 0.62
270_H 284_D 1.28 0.61
68_L 131_Y 1.276 0.60
56_Q 218_N 1.275 0.60
262_N 270_H 1.273 0.60
105_R 114_R 1.261 0.59
139_K 204_E 1.255 0.59
22_F 25_I 1.253 0.58
193_Q 212_I 1.252 0.58
133_L 143_T 1.248 0.58
29_V 34_H 1.246 0.58
21_A 81_R 1.232 0.56
51_G 279_E 1.225 0.56
228_A 243_A 1.212 0.55
170_V 177_N 1.207 0.54
222_G 233_A 1.206 0.54
278_F 285_K 1.199 0.53
156_F 180_T 1.196 0.53
143_T 193_Q 1.196 0.53
30_S 196_Q 1.196 0.53
68_L 210_M 1.186 0.52
219_V 224_V 1.156 0.49
218_N 223_G 1.153 0.49
223_G 243_A 1.153 0.49
120_S 144_M 1.152 0.49
15_D 173_E 1.151 0.49
113_I 137_L 1.144 0.48
191_D 195_A 1.141 0.48
113_I 141_T 1.14 0.48
156_F 172_I 1.135 0.47
84_D 89_S 1.122 0.46
62_L 124_Y 1.115 0.45
198_K 203_D 1.107 0.45
40_V 107_H 1.107 0.45
68_L 132_F 1.098 0.44
240_Q 244_K 1.084 0.43
199_F 246_V 1.082 0.42
123_L 144_M 1.081 0.42
56_Q 257_I 1.077 0.42
218_N 221_L 1.077 0.42
5_T 172_I 1.064 0.41
22_F 56_Q 1.061 0.40
270_H 285_K 1.055 0.40
257_I 282_T 1.052 0.40
280_T 283_E 1.046 0.39
120_S 150_L 1.045 0.39
107_H 113_I 1.043 0.39
218_N 224_V 1.032 0.38
17_S 24_N 1.032 0.38
186_L 212_I 1.017 0.37
40_V 105_R 1.011 0.36
270_H 283_E 1.01 0.36
192_K 196_Q 1.008 0.36
280_T 285_K 1.006 0.36
265_L 278_F 1.001 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4mzwA20.90621000.548Contact Map0.615
3c8eA211000.575Contact Map0.647
4ecjA20.79511000.724Contact Map0.566
4l8eA10.78471000.725Contact Map0.522
4ikhA10.82641000.725Contact Map0.515
3gx0A10.73261000.729Contact Map0.497
4mf5A10.84721000.73Contact Map0.468
1k0dA40.76041000.732Contact Map0.593
4ivfA80.75691000.733Contact Map0.59
4f0bA20.72921000.737Contact Map0.61
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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