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OPENSEQ.org
YGHO - Putative uncharacterized protein YghO (Fragment)
UniProt: Q46840 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12999
Length: 366 (365)
Sequences: 388
Seq/Len: 1.06
YGHO
Paralog alert: 0.06 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
156_K 159_D 3.403 1.00
159_D 360_R 3.299 1.00
156_K 360_R 3.02 1.00
45_I 106_Q 2.729 1.00
100_E 154_Y 2.494 0.99
158_I 340_T 2.453 0.99
86_I 91_V 2.342 0.99
196_R 199_E 2.323 0.99
97_G 100_E 2.322 0.99
78_G 103_L 2.285 0.99
290_R 330_D 2.281 0.99
190_R 246_E 2.155 0.98
127_I 360_R 2.118 0.97
87_D 148_H 2.103 0.97
246_E 249_S 2.074 0.97
156_K 339_E 2.035 0.96
339_E 360_R 2.01 0.96
85_A 92_F 1.969 0.95
89_P 151_Q 1.926 0.95
125_L 146_A 1.902 0.94
1_N 4_D 1.852 0.93
42_D 224_H 1.842 0.93
202_Q 223_E 1.829 0.93
260_N 291_T 1.813 0.92
50_V 57_I 1.804 0.92
23_I 280_L 1.801 0.92
92_F 148_H 1.781 0.91
61_I 99_A 1.746 0.90
83_I 92_F 1.7 0.88
337_I 344_M 1.698 0.88
89_P 93_A 1.684 0.88
14_S 56_Q 1.645 0.86
22_W 25_P 1.639 0.86
159_D 339_E 1.632 0.86
23_I 262_N 1.62 0.85
103_L 111_I 1.605 0.84
101_A 105_S 1.598 0.84
12_P 22_W 1.592 0.84
154_Y 258_L 1.573 0.83
241_M 329_I 1.538 0.81
126_L 357_K 1.533 0.80
162_A 335_S 1.521 0.80
100_E 364_K 1.495 0.78
45_I 67_T 1.495 0.78
99_A 103_L 1.489 0.78
263_E 291_T 1.477 0.77
162_A 359_Y 1.475 0.77
53_K 88_D 1.46 0.76
194_R 239_D 1.451 0.75
293_R 335_S 1.447 0.75
193_N 196_R 1.441 0.74
190_R 200_E 1.433 0.74
97_G 152_L 1.427 0.73
128_E 358_R 1.41 0.72
97_G 101_A 1.409 0.72
93_A 151_Q 1.397 0.71
77_T 110_K 1.391 0.70
125_L 149_I 1.365 0.68
13_S 22_W 1.364 0.68
146_A 150_E 1.351 0.67
268_L 276_G 1.35 0.67
216_W 293_R 1.349 0.67
250_A 302_E 1.344 0.67
52_K 57_I 1.337 0.66
252_C 303_Y 1.337 0.66
161_L 358_R 1.335 0.66
240_D 327_R 1.316 0.64
78_G 102_W 1.308 0.64
111_I 154_Y 1.299 0.63
126_L 272_L 1.289 0.62
10_A 27_F 1.284 0.61
165_M 332_L 1.284 0.61
160_L 225_E 1.282 0.61
143_P 146_A 1.266 0.60
80_F 149_I 1.264 0.60
212_W 336_W 1.245 0.58
138_M 336_W 1.24 0.57
212_W 298_G 1.235 0.57
83_I 148_H 1.231 0.57
158_I 338_L 1.231 0.57
22_W 84_D 1.217 0.55
333_E 357_K 1.216 0.55
61_I 80_F 1.211 0.55
188_T 249_S 1.203 0.54
160_L 336_W 1.196 0.53
268_L 279_K 1.188 0.53
127_I 159_D 1.185 0.52
13_S 27_F 1.184 0.52
4_D 258_L 1.184 0.52
178_K 252_C 1.178 0.52
267_D 283_R 1.175 0.51
100_E 111_I 1.174 0.51
100_E 366_I 1.174 0.51
278_A 282_W 1.168 0.51
21_N 133_P 1.168 0.51
7_A 57_I 1.167 0.51
58_V 91_V 1.161 0.50
61_I 295_P 1.158 0.50
102_W 127_I 1.155 0.49
26_L 270_G 1.153 0.49
34_L 221_F 1.149 0.49
138_M 333_E 1.145 0.49
7_A 52_K 1.14 0.48
69_H 73_Y 1.14 0.48
23_I 223_E 1.138 0.48
71_E 326_R 1.138 0.48
89_P 148_H 1.136 0.48
77_T 112_S 1.134 0.48
11_F 57_I 1.131 0.47
49_W 102_W 1.12 0.46
149_I 362_Y 1.114 0.46
16_Y 140_H 1.112 0.45
238_P 329_I 1.11 0.45
207_I 297_M 1.106 0.45
120_N 298_G 1.106 0.45
210_S 300_R 1.099 0.44
51_A 59_G 1.093 0.44
264_A 276_G 1.093 0.44
210_S 301_D 1.09 0.43
242_I 310_P 1.086 0.43
63_A 99_A 1.084 0.43
130_F 143_P 1.084 0.43
34_L 61_I 1.082 0.43
54_A 269_N 1.078 0.42
63_A 246_E 1.077 0.42
186_K 248_D 1.077 0.42
11_F 15_L 1.076 0.42
90_Q 362_Y 1.076 0.42
51_A 58_V 1.075 0.42
39_P 228_T 1.072 0.42
267_D 279_K 1.072 0.42
3_N 53_K 1.072 0.42
241_M 292_A 1.071 0.42
167_R 171_T 1.071 0.42
244_I 251_P 1.069 0.41
297_M 344_M 1.067 0.41
104_K 366_I 1.063 0.41
86_I 96_F 1.062 0.41
183_V 186_K 1.06 0.41
111_I 252_C 1.059 0.41
213_Q 253_A 1.056 0.40
237_V 304_Q 1.052 0.40
1_N 143_P 1.05 0.40
41_T 46_W 1.047 0.39
87_D 147_A 1.046 0.39
97_G 154_Y 1.045 0.39
68_L 71_E 1.045 0.39
19_D 140_H 1.043 0.39
41_T 44_I 1.041 0.39
212_W 344_M 1.036 0.38
192_I 246_E 1.035 0.38
212_W 215_N 1.03 0.38
118_N 340_T 1.024 0.37
213_Q 301_D 1.024 0.37
26_L 287_S 1.024 0.37
56_Q 86_I 1.018 0.37
15_L 281_L 1.013 0.36
12_P 16_Y 1.006 0.36
41_T 117_L 1.006 0.36
254_F 298_G 1.005 0.36
34_L 48_A 1.004 0.36
337_I 359_Y 1.001 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2wpxA20.85251000.758Contact Map0.386
3tt2A10.808799.90.805Contact Map0.411
1p0hA10.767899.90.823Contact Map0.434
4iusA10.688599.80.829Contact Map0.39
3frmA60.677699.60.859Contact Map0.409
3g3sA20.661299.50.868Contact Map0.343
3gkrA10.797899.40.88Contact Map0.401
1u6mA40.467299.30.888Contact Map0.411
3zj0A10.464599.20.889Contact Map0.355
1s3zA20.450899.20.889Contact Map0.421
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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