May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
TRPH - Protein TrpH
UniProt: P77766 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14257
Length: 293 (275)
Sequences: 1050
Seq/Len: 3.82
TRPH
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
16_T 42_I 5.521 1.00
188_H 222_D 4.168 1.00
26_E 53_P 4.037 1.00
194_A 222_D 3.777 1.00
187_I 192_G 3.186 1.00
23_L 256_F 3.041 1.00
14_S 28_L 2.944 1.00
188_H 194_A 2.808 1.00
43_T 70_G 2.395 1.00
129_G 151_C 2.308 1.00
71_V 100_L 2.285 1.00
155_S 159_D 2.254 1.00
121_A 171_G 2.241 1.00
99_F 186_V 2.2 1.00
37_V 40_L 2.193 1.00
113_L 116_E 2.17 1.00
129_G 147_F 2.11 1.00
58_I 67_L 2.008 1.00
154_A 160_V 1.943 1.00
14_S 40_L 1.893 1.00
195_V 251_S 1.766 0.99
141_R 161_F 1.741 0.99
123_I 164_Y 1.733 0.99
187_I 194_A 1.725 0.99
232_S 235_E 1.717 0.99
115_A 119_E 1.649 0.99
14_S 32_A 1.641 0.99
110_R 141_R 1.625 0.99
179_T 182_Q 1.617 0.99
87_L 251_S 1.606 0.98
240_A 250_A 1.598 0.98
154_A 159_D 1.585 0.98
32_A 40_L 1.57 0.98
231_Q 239_L 1.542 0.98
48_T 97_C 1.541 0.98
51_I 67_L 1.534 0.98
133_L 150_E 1.526 0.98
51_I 69_P 1.525 0.98
226_V 250_A 1.512 0.97
90_D 93_H 1.51 0.97
46_D 107_R 1.507 0.97
33_V 63_L 1.487 0.97
94_P 98_E 1.452 0.97
46_D 74_S 1.444 0.96
71_V 86_G 1.414 0.96
115_A 127_L 1.414 0.96
86_G 187_I 1.409 0.96
195_V 223_A 1.403 0.96
110_R 161_F 1.402 0.96
23_L 31_R 1.392 0.95
217_A 246_H 1.39 0.95
228_Q 231_Q 1.379 0.95
226_V 239_L 1.379 0.95
110_R 145_A 1.378 0.95
147_F 151_C 1.376 0.95
115_A 144_F 1.362 0.95
88_N 282_W 1.359 0.94
114_I 144_F 1.348 0.94
112_Q 127_L 1.342 0.94
75_T 84_I 1.335 0.94
85_V 251_S 1.331 0.94
117_R 171_G 1.316 0.93
107_R 143_H 1.314 0.93
223_A 278_V 1.313 0.93
52_A 92_T 1.308 0.93
42_I 50_A 1.307 0.93
25_P 29_V 1.303 0.93
39_T 68_I 1.3 0.93
156_S 159_D 1.295 0.92
200_G 231_Q 1.288 0.92
30_H 34_E 1.284 0.92
129_G 150_E 1.277 0.92
29_V 40_L 1.274 0.92
55_R 69_P 1.272 0.92
84_I 187_I 1.25 0.91
217_A 247_H 1.242 0.90
123_I 148_L 1.231 0.90
241_A 245_Q 1.23 0.90
33_V 64_A 1.229 0.90
101_A 105_E 1.226 0.89
180_I 216_F 1.222 0.89
146_R 157_M 1.22 0.89
31_R 264_E 1.218 0.89
181_E 215_H 1.215 0.89
35_M 264_E 1.215 0.89
33_V 65_L 1.212 0.89
216_F 221_G 1.211 0.89
14_S 265_L 1.207 0.88
39_T 66_N 1.203 0.88
142_G 145_A 1.191 0.88
60_R 67_L 1.185 0.87
228_Q 252_Q 1.181 0.87
127_L 139_V 1.179 0.87
24_T 27_A 1.168 0.86
141_R 145_A 1.167 0.86
118_L 171_G 1.166 0.86
141_R 165_L 1.16 0.86
166_A 169_K 1.153 0.85
105_E 109_Q 1.146 0.85
192_G 195_V 1.138 0.84
48_T 89_I 1.133 0.84
29_V 36_R 1.132 0.84
178_C 183_A 1.123 0.83
215_H 219_H 1.11 0.82
107_R 110_R 1.107 0.82
126_A 129_G 1.105 0.82
148_L 154_A 1.09 0.80
24_T 28_L 1.088 0.80
75_T 183_A 1.081 0.80
46_D 110_R 1.08 0.80
154_A 165_L 1.074 0.79
187_I 195_V 1.071 0.79
107_R 141_R 1.062 0.78
110_R 114_I 1.062 0.78
71_V 89_I 1.06 0.78
73_I 183_A 1.059 0.78
84_I 180_I 1.052 0.77
210_K 245_Q 1.05 0.77
57_E 60_R 1.049 0.77
129_G 132_R 1.048 0.77
181_E 185_D 1.047 0.77
122_Q 231_Q 1.046 0.76
58_I 65_L 1.045 0.76
22_C 258_Q 1.044 0.76
125_G 147_F 1.03 0.75
41_A 87_L 1.026 0.75
223_A 249_W 1.023 0.74
110_R 143_H 1.022 0.74
158_A 162_K 1.012 0.73
117_R 174_P 1.01 0.73
84_I 194_A 1.009 0.73
55_R 68_I 1.009 0.73
11_D 15_H 1.007 0.73
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2yb1A10.97271000.368Contact Map0.682
3o0fA10.97611000.377Contact Map0.692
3e38A20.69971000.691Contact Map0.657
1m65A10.73721000.7Contact Map0.503
2anuA60.67241000.705Contact Map0.732
4gc3A10.76791000.709Contact Map0.46
2wjeA10.74061000.709Contact Map0.446
2yxoA20.77131000.716Contact Map0.442
3qy7A10.71671000.717Contact Map0.507
2w9mA20.740699.90.749Contact Map0.384
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.019 seconds.