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OPENSEQ.org
YAGH - Putative beta-xylosidase
UniProt: P77713 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13347
Length: 536 (522)
Sequences: 936
Seq/Len: 1.79
YAGH
Paralog alert: 0.43 [within 20: 0.12] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_D 41_H 6.402 1.00
108_A 114_P 4.751 1.00
196_W 218_K 4.65 1.00
137_R 161_A 4.477 1.00
366_R 527_D 4.263 1.00
83_K 109_P 3.758 1.00
134_D 192_R 3.466 1.00
254_T 258_E 3.344 1.00
54_P 86_L 3.144 1.00
22_E 43_R 3.124 1.00
44_D 47_N 3.11 1.00
251_L 296_I 2.845 1.00
77_L 86_L 2.767 1.00
194_A 301_G 2.671 1.00
24_Y 254_T 2.615 1.00
463_W 478_S 2.614 1.00
220_I 224_Y 2.541 1.00
361_R 364_F 2.511 1.00
37_V 86_L 2.423 1.00
408_A 526_A 2.238 1.00
333_D 344_L 2.223 0.99
159_L 176_L 2.223 0.99
216_R 302_W 2.184 0.99
23_D 43_R 2.145 0.99
478_S 481_G 2.098 0.99
263_Y 294_A 2.097 0.99
514_L 528_F 2.086 0.99
7_I 262_A 2.035 0.99
81_D 85_W 1.962 0.98
161_A 170_S 1.961 0.98
72_I 88_Y 1.946 0.98
392_R 465_R 1.941 0.98
361_R 398_E 1.901 0.98
395_T 530_Y 1.874 0.98
392_R 467_D 1.856 0.98
396_R 463_W 1.85 0.97
396_R 461_S 1.84 0.97
357_S 360_A 1.829 0.97
422_C 487_V 1.828 0.97
108_A 113_G 1.816 0.97
59_S 117_E 1.802 0.97
37_V 88_Y 1.801 0.97
253_Q 257_G 1.797 0.97
57_R 60_M 1.781 0.97
30_T 38_R 1.781 0.97
366_R 525_Y 1.779 0.97
216_R 225_E 1.774 0.97
163_D 167_G 1.763 0.96
177_F 226_L 1.762 0.96
393_A 531_F 1.758 0.96
396_R 529_D 1.747 0.96
174_K 221_D 1.742 0.96
108_A 112_E 1.731 0.96
394_E 530_Y 1.73 0.96
159_L 221_D 1.726 0.96
159_L 220_I 1.712 0.95
7_I 17_L 1.71 0.95
12_N 40_Y 1.707 0.95
361_R 527_D 1.704 0.95
83_K 107_T 1.702 0.95
162_F 167_G 1.691 0.95
261_M 305_V 1.685 0.95
196_W 216_R 1.679 0.95
393_A 410_L 1.668 0.95
336_D 529_D 1.667 0.95
163_D 168_T 1.647 0.94
214_V 232_M 1.642 0.94
163_D 166_T 1.636 0.94
478_S 482_E 1.623 0.93
28_T 187_G 1.62 0.93
38_R 53_T 1.614 0.93
412_C 466_V 1.596 0.93
200_M 212_V 1.577 0.92
332_R 532_T 1.577 0.92
225_E 302_W 1.569 0.92
110_S 114_P 1.568 0.92
262_A 291_T 1.565 0.92
131_F 190_L 1.55 0.91
41_H 49_S 1.53 0.91
358_L 361_R 1.53 0.91
397_M 424_V 1.525 0.90
185_T 201_A 1.516 0.90
245_K 266_S 1.501 0.89
39_I 47_N 1.496 0.89
200_M 214_V 1.479 0.88
396_R 530_Y 1.477 0.88
364_F 527_D 1.47 0.88
345_Q 511_F 1.448 0.87
476_S 486_T 1.448 0.87
391_F 468_V 1.444 0.87
25_Y 112_E 1.443 0.87
358_L 362_P 1.443 0.87
196_W 217_S 1.438 0.87
27_A 75_P 1.427 0.86
212_V 249_G 1.427 0.86
87_L 166_T 1.425 0.86
411_T 513_G 1.424 0.86
27_A 77_L 1.41 0.85
465_R 484_W 1.404 0.85
219_N 224_Y 1.399 0.84
162_F 170_S 1.396 0.84
398_E 461_S 1.396 0.84
160_Q 169_L 1.391 0.84
407_S 515_H 1.389 0.84
334_D 532_T 1.388 0.84
361_R 366_R 1.383 0.84
410_L 531_F 1.375 0.83
395_T 528_F 1.374 0.83
296_I 303_P 1.366 0.82
357_S 361_R 1.365 0.82
390_A 469_D 1.363 0.82
81_D 136_G 1.349 0.81
391_F 512_V 1.347 0.81
260_Y 295_R 1.346 0.81
362_P 366_R 1.345 0.81
359_T 362_P 1.338 0.81
434_I 464_L 1.338 0.81
37_V 54_P 1.324 0.80
214_V 303_P 1.321 0.79
20_Q 84_F 1.318 0.79
28_T 40_Y 1.313 0.79
132_H 138_K 1.312 0.79
357_S 362_P 1.308 0.79
121_M 140_Y 1.302 0.78
41_H 51_V 1.298 0.78
37_V 106_V 1.297 0.78
55_L 72_I 1.29 0.77
220_I 223_P 1.279 0.76
251_L 259_W 1.277 0.76
106_V 118_P 1.277 0.76
195_G 218_K 1.275 0.76
335_F 365_L 1.269 0.76
369_G 518_D 1.262 0.75
294_A 305_V 1.26 0.75
161_A 171_P 1.259 0.75
37_V 72_I 1.257 0.75
40_Y 50_L 1.255 0.74
50_L 53_T 1.254 0.74
53_T 345_Q 1.248 0.74
133_D 136_G 1.247 0.74
3_I 260_Y 1.247 0.74
159_L 224_Y 1.244 0.73
466_V 475_Y 1.24 0.73
19_R 253_Q 1.239 0.73
177_F 215_L 1.237 0.73
253_Q 259_W 1.236 0.73
86_L 106_V 1.232 0.72
41_H 112_E 1.231 0.72
258_E 295_R 1.225 0.72
358_L 527_D 1.223 0.72
130_L 140_Y 1.216 0.71
60_M 106_V 1.215 0.71
27_A 86_L 1.206 0.70
467_D 476_S 1.198 0.69
518_D 526_A 1.195 0.69
87_L 140_Y 1.194 0.69
140_Y 187_G 1.192 0.69
526_A 531_F 1.191 0.69
206_T 210_H 1.19 0.69
397_M 462_V 1.19 0.69
59_S 106_V 1.187 0.68
362_P 527_D 1.186 0.68
139_Y 221_D 1.185 0.68
340_L 367_L 1.181 0.68
57_R 117_E 1.178 0.68
196_W 225_E 1.17 0.67
51_V 112_E 1.17 0.67
408_A 462_V 1.168 0.67
108_A 111_I 1.162 0.66
462_V 489_V 1.154 0.65
249_G 261_M 1.152 0.65
20_Q 79_Y 1.145 0.64
218_K 225_E 1.137 0.64
27_A 54_P 1.133 0.63
399_F 406_Q 1.132 0.63
43_R 130_L 1.13 0.63
27_A 128_P 1.128 0.63
3_I 46_K 1.121 0.62
474_R 486_T 1.119 0.62
246_S 265_T 1.117 0.62
404_F 426_Y 1.117 0.62
478_S 484_W 1.111 0.61
250_S 262_A 1.109 0.61
46_K 252_L 1.106 0.60
397_M 526_A 1.102 0.60
368_Y 527_D 1.1 0.60
394_E 463_W 1.093 0.59
112_E 465_R 1.093 0.59
51_V 111_I 1.091 0.59
134_D 197_Y 1.086 0.58
467_D 474_R 1.08 0.58
193_H 253_Q 1.08 0.58
333_D 341_D 1.074 0.57
13_P 31_F 1.071 0.57
177_F 185_T 1.069 0.56
265_T 292_G 1.063 0.56
76_C 105_L 1.062 0.56
78_S 132_H 1.061 0.56
176_L 220_I 1.059 0.55
243_L 292_G 1.058 0.55
68_D 413_Y 1.058 0.55
344_L 531_F 1.056 0.55
260_Y 293_I 1.056 0.55
54_P 106_V 1.054 0.55
266_S 414_Y 1.052 0.55
191_Y 200_M 1.051 0.55
249_G 262_A 1.046 0.54
37_V 75_P 1.044 0.54
192_R 197_Y 1.044 0.54
478_S 483_T 1.042 0.54
9_T 388_H 1.041 0.53
465_R 478_S 1.039 0.53
245_K 285_C 1.037 0.53
202_A 247_G 1.036 0.53
37_V 59_S 1.033 0.53
72_I 75_P 1.033 0.53
5_N 335_F 1.033 0.53
334_D 529_D 1.03 0.52
212_V 215_L 1.027 0.52
320_V 324_P 1.025 0.52
341_D 344_L 1.024 0.52
12_N 50_L 1.017 0.51
7_I 128_P 1.017 0.51
76_C 129_S 1.014 0.51
394_E 484_W 1.013 0.50
193_H 301_G 1.008 0.50
19_R 254_T 1.005 0.50
19_R 255_H 1.005 0.50
55_L 118_P 1.005 0.50
480_D 483_T 1.004 0.49
187_G 367_L 1.003 0.49
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3c2uA411000.271Contact Map0.727
1yifA40.99441000.274Contact Map0.723
2exhA40.99631000.277Contact Map0.755
1yrzA20.9721000.277Contact Map0.665
3zxkA20.89181000.363Contact Map0.595
2x8sA20.6941000.637Contact Map0.602
3akhA10.79851000.651Contact Map0.528
3cu9A10.51311000.658Contact Map0.648
1uv4A10.50751000.668Contact Map0.659
1gyhA60.52611000.669Contact Map0.709
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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