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OPENSEQ.org
YDIU - UPF0061 protein YdiU
UniProt: P77649 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13980
Length: 478 (477)
Sequences: 1007
Seq/Len: 2.11
YDIU
Paralog alert: 0.04 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
176_L 200_A 4.458 1.00
290_A 317_Y 4.432 1.00
235_T 328_R 4.018 1.00
18_T 114_Y 3.695 1.00
342_D 399_R 3.659 1.00
348_E 395_R 3.63 1.00
353_M 363_T 3.155 1.00
452_N 455_S 3.134 1.00
142_I 236_V 3.066 1.00
358_S 363_T 3.056 1.00
230_I 290_A 2.883 1.00
349_L 363_T 2.813 1.00
207_H 221_D 2.652 1.00
6_V 11_D 2.613 1.00
380_R 390_D 2.557 1.00
127_T 150_I 2.554 1.00
137_M 257_Y 2.54 1.00
198_D 215_Y 2.454 1.00
34_N 131_S 2.44 1.00
37_L 171_V 2.363 1.00
420_A 456_D 2.278 1.00
31_I 440_M 2.27 1.00
429_Q 433_E 2.259 1.00
197_A 215_Y 2.248 1.00
296_R 299_Q 2.233 1.00
8_R 199_F 2.227 1.00
37_L 40_T 2.226 1.00
19_A 65_S 2.11 0.99
236_V 332_K 2.102 0.99
132_L 423_L 2.101 0.99
421_L 457_R 2.092 0.99
421_L 449_A 2.041 0.99
200_A 250_L 1.98 0.99
291_L 318_Q 1.962 0.99
339_Q 402_Q 1.95 0.99
283_F 360_Y 1.908 0.99
52_A 55_W 1.895 0.99
248_M 290_A 1.891 0.99
431_A 442_E 1.877 0.98
53_G 59_A 1.864 0.98
136_A 140_L 1.854 0.98
48_F 51_G 1.848 0.98
197_A 304_F 1.795 0.98
220_S 316_S 1.761 0.97
349_L 353_M 1.741 0.97
324_H 327_E 1.738 0.97
24_P 121_R 1.731 0.97
243_M 290_A 1.73 0.97
144_T 257_Y 1.726 0.97
67_L 90_L 1.715 0.97
135_E 146_R 1.695 0.96
227_A 231_A 1.663 0.96
324_H 328_R 1.662 0.96
26_N 155_S 1.659 0.96
218_W 222_V 1.659 0.96
189_E 192_K 1.646 0.96
449_A 457_R 1.635 0.95
201_I 250_L 1.628 0.95
434_A 442_E 1.603 0.95
40_T 102_M 1.591 0.94
90_L 103_D 1.574 0.94
201_I 215_Y 1.57 0.94
61_L 64_M 1.568 0.94
22_P 89_I 1.562 0.94
297_L 300_T 1.553 0.93
389_F 393_F 1.547 0.93
230_I 243_M 1.533 0.93
103_D 175_H 1.525 0.93
23_T 89_I 1.514 0.92
181_F 250_L 1.514 0.92
111_L 117_M 1.51 0.92
34_N 37_L 1.507 0.92
230_I 317_Y 1.505 0.92
442_E 461_Y 1.49 0.92
89_I 109_A 1.49 0.92
70_V 183_H 1.465 0.91
333_L 349_L 1.465 0.91
137_M 254_T 1.455 0.90
178_F 248_M 1.453 0.90
7_T 11_D 1.441 0.90
31_I 443_L 1.439 0.90
428_A 450_L 1.438 0.89
264_D 465_P 1.436 0.89
332_K 361_T 1.431 0.89
275_S 474_V 1.429 0.89
5_F 11_D 1.425 0.89
368_S 415_Q 1.423 0.89
231_A 328_R 1.416 0.89
149_S 169_M 1.412 0.88
156_P 162_A 1.406 0.88
32_W 131_S 1.403 0.88
72_S 79_W 1.397 0.88
145_T 253_L 1.393 0.87
239_A 270_F 1.372 0.86
88_G 105_H 1.371 0.86
184_F 192_K 1.365 0.86
219_F 310_L 1.353 0.85
224_A 324_H 1.343 0.85
413_L 417_V 1.342 0.85
268_P 354_A 1.331 0.84
173_P 253_L 1.324 0.84
16_T 184_F 1.313 0.83
221_D 224_A 1.313 0.83
69_Q 180_H 1.302 0.82
360_Y 364_F 1.289 0.81
330_R 338_E 1.286 0.81
36_E 451_R 1.284 0.81
239_A 263_L 1.282 0.81
95_L 101_T 1.278 0.80
445_R 460_D 1.274 0.80
23_T 121_R 1.264 0.79
232_Q 328_R 1.264 0.79
132_L 379_L 1.251 0.78
104_W 169_M 1.244 0.78
475_S 478_S 1.24 0.78
198_D 201_I 1.238 0.77
325_Y 329_M 1.229 0.77
381_D 386_R 1.228 0.77
466_P 469_G 1.225 0.76
435_A 440_M 1.223 0.76
302_S 310_L 1.222 0.76
133_A 260_F 1.22 0.76
427_L 430_R 1.219 0.76
127_T 168_L 1.216 0.76
365_R 368_S 1.215 0.76
96_L 100_T 1.207 0.75
305_V 310_L 1.203 0.75
178_F 226_T 1.202 0.74
161_T 436_E 1.201 0.74
56_G 151_V 1.193 0.74
399_R 403_D 1.191 0.74
69_Q 103_D 1.19 0.73
282_S 285_N 1.19 0.73
194_R 215_Y 1.183 0.73
221_D 225_R 1.176 0.72
96_L 102_M 1.171 0.72
423_L 428_A 1.171 0.72
431_A 446_L 1.166 0.71
216_R 309_A 1.16 0.71
157_V 165_G 1.148 0.70
442_E 445_R 1.148 0.70
362_R 366_M 1.145 0.69
197_A 201_I 1.145 0.69
176_L 250_L 1.145 0.69
193_V 197_A 1.142 0.69
25_L 58_E 1.141 0.69
223_V 313_A 1.139 0.69
201_I 218_W 1.139 0.69
17_Y 67_L 1.135 0.68
160_E 274_H 1.134 0.68
18_T 113_P 1.134 0.68
205_W 221_D 1.132 0.68
431_A 443_L 1.132 0.68
123_V 163_E 1.131 0.68
123_V 126_S 1.128 0.68
421_L 456_D 1.127 0.68
105_H 167_M 1.127 0.68
69_Q 105_H 1.126 0.67
122_A 166_A 1.124 0.67
228_S 324_H 1.124 0.67
254_T 257_Y 1.122 0.67
75_Q 83_L 1.113 0.66
132_L 443_L 1.113 0.66
79_W 82_Q 1.112 0.66
234_Q 321_L 1.108 0.66
228_S 320_V 1.106 0.65
261_G 474_V 1.106 0.65
6_V 101_T 1.105 0.65
219_F 298_A 1.104 0.65
231_A 235_T 1.103 0.65
158_Y 162_A 1.102 0.65
16_T 180_H 1.098 0.65
209_A 214_K 1.094 0.64
434_A 439_D 1.094 0.64
100_T 173_P 1.093 0.64
176_L 181_F 1.092 0.64
222_V 297_L 1.089 0.64
447_H 450_L 1.084 0.63
430_R 442_E 1.081 0.63
239_A 272_C 1.079 0.63
330_R 339_Q 1.074 0.62
30_L 52_A 1.073 0.62
56_G 205_W 1.058 0.60
449_A 461_Y 1.057 0.60
380_R 383_F 1.056 0.60
29_R 152_T 1.053 0.60
452_N 457_R 1.046 0.59
427_L 446_L 1.044 0.59
474_V 477_S 1.042 0.59
387_A 391_D 1.041 0.58
178_F 297_L 1.039 0.58
125_R 163_E 1.038 0.58
32_W 444_H 1.038 0.58
213_D 218_W 1.036 0.58
227_A 328_R 1.031 0.57
48_F 52_A 1.029 0.57
397_R 400_L 1.027 0.57
448_E 451_R 1.025 0.57
391_D 416_S 1.025 0.57
248_M 283_F 1.021 0.56
93_E 203_H 1.018 0.56
151_V 169_M 1.017 0.56
369_L 456_D 1.017 0.56
42_S 97_A 1.016 0.56
469_G 472_L 1.016 0.56
153_S 239_A 1.015 0.56
12_E 16_T 1.015 0.56
52_A 56_G 1.009 0.55
406_S 409_E 1.006 0.55
26_N 121_R 1.005 0.54
411_Q 415_Q 1.002 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2o4tA10.20547.80.981Contact Map0.294
2hh6A10.221826.60.984Contact Map0.274
3r70A10.543921.60.985Contact Map0.038
3tm0A10.374516.60.985Contact Map0.188
3atsA10.491615.40.986Contact Map0.087
2ppqA10.560714.80.986Contact Map0.201
2olcA20.558610.30.987Contact Map0.147
1nd4A20.49589.70.987Contact Map0.322
2oc6A20.2517.20.988Contact Map0.092
2ixsA20.29297.20.988Contact Map0.101
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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