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OPENSEQ.org
YDEU - Uncharacterized protein YdeU
UniProt: P77286 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene:
Length: 466 (454)
Sequences: 751
Seq/Len: 1.65
YDEU
Paralog alert: 0.85 [within 20: 0.10] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
53_V 72_I 3.61 1.00
29_A 38_T 2.925 1.00
25_M 53_V 2.687 1.00
43_V 47_T 2.671 1.00
27_F 71_L 2.421 1.00
338_Q 370_R 2.359 1.00
70_E 108_N 2.281 1.00
441_W 461_G 2.28 1.00
18_Y 51_T 2.235 0.99
282_S 312_V 2.159 0.99
55_V 71_L 2.059 0.99
122_D 130_P 2.031 0.99
122_D 128_N 2.018 0.99
70_E 73_E 1.977 0.98
311_S 340_Q 1.928 0.98
267_T 281_D 1.895 0.98
124_P 128_N 1.876 0.97
394_Y 427_R 1.856 0.97
18_Y 25_M 1.856 0.97
131_P 135_P 1.796 0.96
19_T 48_Q 1.784 0.96
339_A 371_L 1.781 0.96
366_N 402_N 1.773 0.96
29_A 69_I 1.757 0.96
44_K 75_G 1.732 0.95
168_G 313_E 1.731 0.95
280_V 312_V 1.726 0.95
168_G 188_R 1.696 0.94
279_Y 338_Q 1.689 0.94
122_D 133_V 1.674 0.94
53_V 71_L 1.662 0.94
335_V 373_V 1.658 0.93
291_N 303_Y 1.646 0.93
25_M 51_T 1.643 0.93
340_Q 370_R 1.635 0.93
65_T 69_I 1.622 0.92
122_D 126_P 1.621 0.92
65_T 68_G 1.597 0.92
190_V 211_V 1.587 0.91
279_Y 313_E 1.582 0.91
30_T 37_P 1.579 0.91
13_T 42_N 1.568 0.91
120_P 123_T 1.564 0.91
120_P 124_P 1.539 0.90
396_E 427_R 1.533 0.89
123_T 129_N 1.53 0.89
27_F 55_V 1.526 0.89
32_G 36_S 1.518 0.89
24_L 54_R 1.495 0.88
128_N 133_V 1.492 0.88
62_G 65_T 1.491 0.88
129_N 132_V 1.487 0.87
289_F 307_G 1.482 0.87
126_P 130_P 1.481 0.87
27_F 53_V 1.477 0.87
109_W 279_Y 1.474 0.87
84_L 98_L 1.467 0.86
31_L 57_N 1.447 0.85
147_S 150_S 1.438 0.85
77_N 81_N 1.43 0.84
187_M 212_L 1.426 0.84
10_N 28_N 1.411 0.83
166_R 281_D 1.399 0.83
427_R 445_G 1.399 0.83
341_I 457_Q 1.395 0.82
125_D 129_N 1.388 0.82
317_T 336_Q 1.387 0.82
126_P 137_G 1.384 0.82
62_G 68_G 1.376 0.81
123_T 127_I 1.366 0.81
46_D 74_V 1.365 0.80
267_T 313_E 1.363 0.80
43_V 234_M 1.359 0.80
166_R 313_E 1.358 0.80
133_V 137_G 1.353 0.80
234_M 285_L 1.352 0.80
370_R 398_N 1.351 0.80
72_I 108_N 1.341 0.79
50_N 80_G 1.332 0.78
128_N 135_P 1.33 0.78
83_A 89_V 1.302 0.76
335_V 375_T 1.302 0.76
313_E 340_Q 1.3 0.76
47_T 80_G 1.293 0.75
130_P 133_V 1.292 0.75
188_R 281_D 1.292 0.75
17_N 46_D 1.289 0.75
27_F 41_M 1.284 0.75
188_R 213_Q 1.284 0.75
26_T 54_R 1.276 0.74
442_G 445_G 1.272 0.74
36_S 60_G 1.266 0.73
11_V 40_K 1.265 0.73
118_V 122_D 1.26 0.73
178_S 321_G 1.259 0.72
126_P 129_N 1.254 0.72
438_L 464_Y 1.253 0.72
123_T 126_P 1.241 0.71
120_P 130_P 1.236 0.70
250_G 310_A 1.235 0.70
40_K 70_E 1.234 0.70
282_S 314_G 1.229 0.70
124_P 130_P 1.229 0.70
45_G 76_G 1.228 0.70
163_L 269_Y 1.222 0.69
341_I 369_T 1.215 0.69
164_H 169_E 1.212 0.68
124_P 133_V 1.207 0.68
123_T 135_P 1.207 0.68
31_L 69_I 1.204 0.68
120_P 128_N 1.202 0.67
14_V 17_N 1.2 0.67
229_W 266_A 1.199 0.67
128_N 132_V 1.197 0.67
309_T 344_M 1.193 0.67
188_R 313_E 1.19 0.66
190_V 441_W 1.189 0.66
60_G 65_T 1.184 0.66
214_L 440_L 1.183 0.66
128_N 131_P 1.182 0.65
121_A 127_I 1.177 0.65
123_T 132_V 1.175 0.65
119_T 125_D 1.174 0.65
401_N 422_N 1.171 0.64
67_N 70_E 1.158 0.63
279_Y 340_Q 1.158 0.63
29_A 58_I 1.156 0.63
68_G 148_Y 1.156 0.63
6_G 9_G 1.154 0.63
166_R 169_E 1.152 0.63
15_N 33_G 1.152 0.63
186_W 215_G 1.147 0.62
435_N 444_V 1.144 0.62
130_P 135_P 1.144 0.62
11_V 42_N 1.142 0.62
163_L 188_R 1.141 0.61
278_A 316_Y 1.14 0.61
99_A 112_T 1.135 0.61
399_W 422_N 1.134 0.61
100_K 105_D 1.133 0.61
45_G 77_N 1.133 0.61
38_T 74_V 1.132 0.61
192_G 209_R 1.131 0.60
397_A 451_K 1.13 0.60
128_N 134_D 1.13 0.60
370_R 425_E 1.124 0.60
186_W 211_V 1.124 0.60
127_I 132_V 1.122 0.60
121_A 124_P 1.119 0.59
126_P 132_V 1.117 0.59
281_D 313_E 1.116 0.59
24_L 52_R 1.115 0.59
121_A 135_P 1.112 0.59
84_L 192_G 1.112 0.59
42_N 72_I 1.109 0.58
122_D 137_G 1.107 0.58
51_T 80_G 1.106 0.58
132_V 135_P 1.106 0.58
427_R 441_W 1.106 0.58
291_N 355_D 1.105 0.58
263_G 313_E 1.103 0.58
319_E 375_T 1.102 0.57
15_N 44_K 1.102 0.57
211_V 421_R 1.102 0.57
102_K 106_E 1.101 0.57
45_G 74_V 1.099 0.57
34_D 57_N 1.097 0.57
456_T 462_V 1.095 0.57
127_I 131_P 1.092 0.56
212_L 392_Q 1.086 0.56
50_N 57_N 1.085 0.56
447_Q 452_G 1.084 0.56
333_W 375_T 1.084 0.56
33_G 79_A 1.082 0.55
257_I 291_N 1.081 0.55
286_Y 306_R 1.078 0.55
236_G 261_S 1.076 0.55
122_D 134_D 1.074 0.55
399_W 403_S 1.073 0.54
275_K 399_W 1.071 0.54
425_E 464_Y 1.068 0.54
17_N 133_V 1.065 0.54
276_T 333_W 1.064 0.53
124_P 129_N 1.062 0.53
125_D 133_V 1.062 0.53
55_V 60_G 1.056 0.53
127_I 130_P 1.056 0.53
438_L 462_V 1.055 0.53
65_T 110_Y 1.053 0.52
32_G 35_N 1.051 0.52
17_N 20_G 1.051 0.52
124_P 135_P 1.048 0.52
79_A 100_K 1.048 0.52
288_W 307_G 1.048 0.52
128_N 137_G 1.044 0.51
458_G 464_Y 1.044 0.51
403_S 434_V 1.044 0.51
227_D 268_W 1.042 0.51
129_N 135_P 1.039 0.51
22_N 58_I 1.038 0.51
119_T 122_D 1.033 0.50
38_T 69_I 1.033 0.50
126_P 135_P 1.032 0.50
20_G 307_G 1.03 0.50
111_L 166_R 1.03 0.50
124_P 137_G 1.029 0.50
34_D 37_P 1.028 0.50
73_E 108_N 1.024 0.49
43_V 72_I 1.023 0.49
396_E 443_N 1.018 0.49
341_I 404_K 1.018 0.49
284_A 310_A 1.017 0.49
386_G 389_R 1.017 0.49
55_V 195_R 1.017 0.49
62_G 69_I 1.015 0.48
109_W 313_E 1.014 0.48
84_L 96_Y 1.014 0.48
214_L 438_L 1.014 0.48
50_N 83_A 1.012 0.48
341_I 444_V 1.011 0.48
441_W 458_G 1.01 0.48
188_R 445_G 1.009 0.48
233_V 262_A 1.006 0.47
25_M 41_M 1.005 0.47
121_A 131_P 1.004 0.47
168_G 311_S 1.003 0.47
79_A 83_A 1 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3sltA10.65021000.577Contact Map0.487
3aehA20.63521000.599Contact Map0.491
3qq2A30.59871000.601Contact Map0.529
1uynX10.62021000.672Contact Map0.368
3kvnX20.90341000.687Contact Map0.416
3ml3A10.28541000.726Contact Map0.572
3syjA10.35191000.761Contact Map0.636
3h09A20.276899.90.776Contact Map0.694
1dabA10.236199.90.789Contact Map0.648
1wxrA10.289799.90.807Contact Map0.527
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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