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OPENSEQ.org
EUTD - Ethanolamine utilization protein EutD
UniProt: P77218 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14188
Length: 338 (324)
Sequences: 2032
Seq/Len: 6.27
EUTD
Paralog alert: 0.45 [within 20: 0.15] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
174_T 177_Q 4.761 1.00
48_P 52_R 4.035 1.00
17_V 118_V 3.508 1.00
220_Q 223_E 3.481 1.00
43_I 116_A 3.204 1.00
225_V 234_V 3.189 1.00
111_V 116_A 3.086 1.00
80_F 115_K 3.004 1.00
165_A 266_V 2.839 1.00
16_R 41_T 2.69 1.00
198_R 261_K 2.503 1.00
46_A 51_L 2.424 1.00
223_E 227_E 2.348 1.00
246_P 250_A 2.289 1.00
110_M 115_K 2.242 1.00
80_F 110_M 2.189 1.00
47_N 69_D 2.126 1.00
14_P 41_T 2.088 1.00
48_P 69_D 2.024 1.00
82_H 93_P 1.998 1.00
55_A 62_M 1.988 1.00
41_T 66_Q 1.983 1.00
33_Y 313_I 1.958 1.00
272_A 275_I 1.925 1.00
34_L 316_A 1.891 1.00
35_H 65_L 1.842 1.00
226_R 234_V 1.782 1.00
150_I 163_G 1.772 1.00
100_L 109_A 1.765 1.00
19_F 316_A 1.763 1.00
23_L 50_E 1.761 1.00
25_Q 29_K 1.722 1.00
18_V 111_V 1.708 1.00
62_M 65_L 1.679 1.00
52_R 56_L 1.678 1.00
32_Q 36_Q 1.668 1.00
176_A 224_I 1.663 1.00
183_L 229_A 1.656 1.00
216_A 219_Q 1.647 1.00
54_F 58_H 1.64 1.00
84_W 100_L 1.637 1.00
83_R 112_S 1.635 1.00
8_E 11_L 1.614 1.00
226_R 257_P 1.613 1.00
233_V 257_P 1.609 1.00
43_I 66_Q 1.602 1.00
83_R 113_A 1.601 1.00
25_Q 58_H 1.597 1.00
203_S 214_C 1.591 0.99
80_F 100_L 1.586 0.99
175_A 220_Q 1.583 0.99
76_M 79_E 1.577 0.99
235_D 256_S 1.575 0.99
172_Q 213_P 1.571 0.99
183_L 228_R 1.557 0.99
16_R 43_I 1.557 0.99
84_W 99_K 1.553 0.99
202_L 275_I 1.531 0.99
18_V 116_A 1.524 0.99
172_Q 217_N 1.521 0.99
118_V 319_A 1.518 0.99
53_Q 57_S 1.507 0.99
131_L 169_V 1.484 0.99
179_A 224_I 1.474 0.99
246_P 261_K 1.453 0.99
204_F 212_H 1.452 0.99
235_D 238_L 1.45 0.99
34_L 40_A 1.446 0.99
187_E 229_A 1.441 0.99
45_V 110_M 1.435 0.99
22_A 44_L 1.435 0.99
269_S 272_A 1.419 0.99
121_A 130_V 1.406 0.98
93_P 97_L 1.404 0.98
25_Q 54_F 1.4 0.98
47_N 71_H 1.389 0.98
276_G 279_I 1.387 0.98
180_D 228_R 1.384 0.98
15_A 117_D 1.373 0.98
88_A 91_K 1.37 0.98
87_R 91_K 1.364 0.98
225_V 232_L 1.364 0.98
32_Q 60_V 1.346 0.98
78_E 97_L 1.332 0.98
201_M 234_V 1.328 0.98
146_T 177_Q 1.32 0.97
51_L 67_V 1.317 0.97
163_G 189_W 1.31 0.97
176_A 220_Q 1.304 0.97
200_A 243_A 1.304 0.97
16_R 66_Q 1.299 0.97
55_A 60_V 1.298 0.97
71_H 101_T 1.292 0.97
240_F 279_I 1.29 0.97
81_A 84_W 1.288 0.97
188_T 294_Q 1.284 0.97
76_M 115_K 1.279 0.97
16_R 117_D 1.277 0.97
175_A 222_T 1.276 0.97
76_M 80_F 1.259 0.96
54_F 57_S 1.253 0.96
164_F 267_F 1.25 0.96
164_F 280_A 1.248 0.96
109_A 113_A 1.247 0.96
186_A 232_L 1.242 0.96
87_R 90_E 1.24 0.96
20_P 107_A 1.227 0.96
182_A 266_V 1.223 0.95
200_A 262_A 1.219 0.95
153_M 288_A 1.208 0.95
201_M 222_T 1.207 0.95
79_E 115_K 1.189 0.94
189_W 264_V 1.186 0.94
66_Q 115_K 1.184 0.94
84_W 91_K 1.178 0.94
196_E 233_V 1.176 0.94
301_H 319_A 1.161 0.93
24_D 27_V 1.159 0.93
198_R 233_V 1.159 0.93
151_F 167_C 1.158 0.93
267_F 276_G 1.153 0.93
104_L 121_A 1.152 0.93
80_F 84_W 1.149 0.93
150_I 188_T 1.148 0.93
134_G 296_L 1.143 0.93
219_Q 223_E 1.138 0.93
182_A 199_V 1.137 0.93
47_N 50_E 1.137 0.93
201_M 218_V 1.127 0.92
33_Y 310_Q 1.124 0.92
190_R 196_E 1.123 0.92
18_V 107_A 1.123 0.92
147_L 296_L 1.122 0.92
95_D 98_E 1.12 0.92
29_K 309_V 1.115 0.92
79_E 113_A 1.105 0.91
24_D 124_L 1.102 0.91
81_A 85_L 1.098 0.91
240_F 244_F 1.097 0.91
160_P 261_K 1.096 0.91
224_I 227_E 1.091 0.90
80_F 113_A 1.089 0.90
145_K 180_D 1.088 0.90
28_L 60_V 1.083 0.90
172_Q 214_C 1.082 0.90
7_R 11_L 1.078 0.90
45_V 68_I 1.078 0.90
244_F 265_M 1.074 0.89
81_A 100_L 1.072 0.89
179_A 183_L 1.07 0.89
55_A 61_A 1.064 0.89
33_Y 37_Q 1.055 0.88
13_A 324_Q 1.048 0.88
49_F 52_R 1.047 0.88
146_T 170_V 1.03 0.87
49_F 53_Q 1.029 0.87
189_W 195_E 1.028 0.86
242_A 248_V 1.027 0.86
203_S 212_H 1.026 0.86
224_I 228_R 1.026 0.86
245_V 282_R 1.021 0.86
150_I 165_A 1.021 0.86
134_G 300_M 1.018 0.86
14_P 320_A 1.011 0.85
222_T 234_V 1.01 0.85
173_P 181_I 1.009 0.85
53_Q 56_L 1.005 0.85
190_R 231_K 1.004 0.85
44_L 51_L 1.003 0.85
132_R 135_L 1.003 0.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vmiA10.9971000.355Contact Map0.749
4e4rA10.94971000.365Contact Map0.732
1r5jA20.96451000.369Contact Map0.755
1td9A60.94671000.373Contact Map0.784
2af4C20.96151000.38Contact Map0.795
1ycoA20.81071000.406Contact Map0.614
3uf6A20.84321000.424Contact Map0.697
4jqpA20.88461000.573Contact Map0.519
3lxyA10.86691000.575Contact Map0.525
1u7nA20.85211000.584Contact Map0.76
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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