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OPENSEQ.org
YAGQ - Uncharacterized protein YagQ
UniProt: P77183 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13556
Length: 318 (285)
Sequences: 957
Seq/Len: 3.36
YAGQ
Paralog alert: 0.19 [within 20: 0.01] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
265_H 271_R 3.334 1.00
295_L 302_A 3.258 1.00
42_V 121_L 3.141 1.00
201_Y 302_A 2.672 1.00
249_G 281_V 2.497 1.00
185_R 207_D 2.419 1.00
42_V 90_M 2.405 1.00
47_V 97_E 2.267 1.00
44_V 119_L 2.264 1.00
99_R 118_T 2.146 1.00
223_V 240_A 2.076 1.00
182_I 193_A 2.068 1.00
223_V 245_P 2.065 1.00
48_E 118_T 2.021 1.00
40_G 65_E 1.999 1.00
271_R 275_T 1.926 1.00
49_I 53_A 1.813 0.99
270_S 273_E 1.811 0.99
81_A 100_Y 1.78 0.99
285_P 293_L 1.726 0.99
237_L 250_A 1.709 0.99
81_A 85_E 1.667 0.98
33_E 37_S 1.621 0.98
218_D 221_T 1.599 0.98
298_L 301_V 1.593 0.98
251_L 281_V 1.589 0.98
238_Q 267_L 1.584 0.98
295_L 301_V 1.56 0.97
222_A 246_F 1.553 0.97
247_Y 281_V 1.549 0.97
196_A 298_L 1.548 0.97
74_S 77_C 1.546 0.97
243_A 276_Q 1.54 0.97
78_V 117_I 1.511 0.97
183_Y 236_V 1.503 0.97
44_V 63_V 1.487 0.96
248_L 277_I 1.46 0.96
195_L 198_A 1.459 0.96
300_E 303_S 1.44 0.95
257_H 261_L 1.432 0.95
60_Q 172_V 1.427 0.95
289_D 292_T 1.423 0.95
44_V 121_L 1.423 0.95
136_R 141_K 1.417 0.95
180_L 222_A 1.408 0.95
224_I 301_V 1.402 0.94
247_Y 300_E 1.402 0.94
192_T 297_V 1.398 0.94
227_C 233_E 1.39 0.94
36_M 131_L 1.379 0.94
180_L 301_V 1.379 0.94
195_L 298_L 1.372 0.93
74_S 228_H 1.368 0.93
45_T 122_H 1.366 0.93
135_N 139_Q 1.361 0.93
217_I 221_T 1.36 0.93
242_E 273_E 1.355 0.93
54_A 253_S 1.353 0.93
195_L 295_L 1.339 0.92
194_S 291_H 1.338 0.92
78_V 186_S 1.331 0.92
285_P 292_T 1.321 0.92
54_A 188_E 1.313 0.91
287_A 292_T 1.301 0.91
110_V 207_D 1.299 0.91
262_Q 266_E 1.287 0.90
39_K 64_R 1.282 0.90
54_A 114_G 1.278 0.90
245_P 248_L 1.275 0.90
182_I 192_T 1.264 0.89
64_R 68_R 1.243 0.88
245_P 276_Q 1.231 0.87
243_A 248_L 1.224 0.87
269_W 273_E 1.222 0.87
242_E 269_W 1.217 0.87
34_A 62_V 1.214 0.86
114_G 230_L 1.21 0.86
208_L 228_H 1.207 0.86
234_L 263_K 1.203 0.86
132_A 136_R 1.202 0.86
99_R 116_G 1.199 0.86
72_F 187_L 1.197 0.85
188_E 293_L 1.194 0.85
188_E 253_S 1.189 0.85
88_E 92_S 1.186 0.85
208_L 232_R 1.185 0.85
54_A 112_P 1.178 0.84
77_C 228_H 1.174 0.84
85_E 96_R 1.17 0.84
46_L 59_A 1.166 0.83
219_T 244_K 1.159 0.83
182_I 189_A 1.158 0.83
44_V 82_A 1.158 0.83
101_G 260_R 1.152 0.82
210_P 264_L 1.152 0.82
24_H 31_A 1.138 0.81
112_P 260_R 1.135 0.81
180_L 196_A 1.131 0.81
120_T 147_Y 1.128 0.80
55_R 79_E 1.127 0.80
46_L 49_I 1.125 0.80
257_H 279_A 1.124 0.80
201_Y 222_A 1.117 0.80
272_E 275_T 1.109 0.79
285_P 296_S 1.102 0.78
205_I 289_D 1.102 0.78
112_P 188_E 1.099 0.78
283_I 286_K 1.094 0.78
112_P 256_T 1.089 0.77
85_E 98_I 1.083 0.77
72_F 230_L 1.081 0.76
34_A 41_A 1.077 0.76
177_C 200_G 1.075 0.76
240_A 248_L 1.075 0.76
82_A 119_L 1.074 0.76
55_R 59_A 1.068 0.75
148_D 151_A 1.066 0.75
92_S 96_R 1.065 0.75
181_M 223_V 1.064 0.75
233_E 290_A 1.064 0.75
248_L 269_W 1.063 0.75
250_A 256_T 1.061 0.74
59_A 225_L 1.059 0.74
261_L 275_T 1.054 0.74
255_R 259_L 1.047 0.73
261_L 274_T 1.045 0.73
303_S 307_H 1.04 0.72
225_L 240_A 1.04 0.72
238_Q 242_E 1.032 0.72
112_P 228_H 1.023 0.71
188_E 256_T 1.019 0.70
46_L 57_L 1.017 0.70
103_G 200_G 1.009 0.69
54_A 230_L 1.009 0.69
226_L 253_S 1.006 0.69
256_T 260_R 1.003 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2we8A20.94031000.177Contact Map0.596
3on5A20.95281000.235Contact Map0.684
3fwzA20.361696.60.929Contact Map0.663
1id1A20.389996.50.93Contact Map0.513
3l9wA20.437196.20.932Contact Map0.552
2g1uA10.4057960.933Contact Map0.402
3llvA10.374295.90.933Contact Map0.577
1lssA40.364895.80.934Contact Map0.541
4g65A20.446595.80.934Contact Map0.4
2hmtA20.380594.30.939Contact Map0.581
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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