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YCJT - Uncharacterized glycosyl hydrolase YcjT
UniProt: P77154 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13917
Length: 755 (733)
Sequences: 754
Seq/Len: 1.03
YCJT
Paralog alert: 0.24 [within 20: 0.02] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
464_E 480_N 4.494 1.00
589_S 592_S 3.91 1.00
449_A 495_A 3.213 1.00
418_A 487_M 2.914 1.00
480_N 535_D 2.827 1.00
379_F 444_L 2.779 1.00
448_T 491_N 2.711 1.00
287_N 688_Q 2.706 1.00
79_N 113_S 2.687 1.00
283_R 298_D 2.588 1.00
9_E 92_R 2.524 0.99
593_C 621_R 2.494 0.99
26_Q 123_V 2.471 0.99
143_D 223_A 2.439 0.99
116_T 138_T 2.429 0.99
88_E 108_R 2.365 0.99
114_G 141_D 2.309 0.99
127_Q 270_A 2.304 0.99
138_T 226_T 2.303 0.99
421_A 445_L 2.302 0.99
670_V 679_L 2.299 0.99
118_A 138_T 2.262 0.98
259_C 263_S 2.228 0.98
419_D 483_Y 2.192 0.98
283_R 294_Q 2.167 0.98
120_R 134_E 2.143 0.97
542_A 603_R 2.137 0.97
616_G 662_G 2.083 0.97
39_E 103_R 2.064 0.97
76_I 137_I 2.044 0.96
424_V 444_L 2.001 0.96
359_W 440_E 1.96 0.95
598_Q 624_L 1.946 0.95
118_A 136_T 1.946 0.95
701_L 729_V 1.909 0.94
139_P 221_L 1.909 0.94
366_Q 447_E 1.896 0.94
136_T 228_T 1.881 0.93
710_I 722_L 1.875 0.93
299_Y 303_H 1.868 0.93
98_S 272_T 1.835 0.92
461_D 519_E 1.831 0.92
285_T 691_S 1.825 0.92
628_S 667_F 1.815 0.92
356_R 440_E 1.809 0.92
106_V 140_L 1.773 0.91
134_E 228_T 1.748 0.90
222_H 225_E 1.742 0.89
719_S 726_L 1.734 0.89
119_S 135_I 1.728 0.89
316_S 331_V 1.724 0.89
263_S 266_Q 1.718 0.89
482_A 531_L 1.714 0.88
544_N 547_K 1.706 0.88
99_G 271_S 1.688 0.87
689_Q 704_T 1.657 0.86
26_Q 302_Y 1.65 0.86
486_Y 588_F 1.624 0.85
113_S 142_A 1.62 0.84
5_V 298_D 1.618 0.84
126_D 270_A 1.6 0.83
578_V 618_V 1.594 0.83
435_S 439_H 1.593 0.83
89_A 106_V 1.576 0.82
148_I 229_L 1.562 0.81
482_A 580_L 1.562 0.81
413_E 455_R 1.561 0.81
123_V 302_Y 1.557 0.81
475_T 607_D 1.546 0.80
621_R 671_S 1.54 0.80
6_T 93_E 1.531 0.79
83_F 105_V 1.523 0.79
136_T 226_T 1.52 0.79
287_N 689_Q 1.516 0.79
130_L 267_L 1.508 0.78
693_P 702_Q 1.504 0.78
271_S 658_A 1.487 0.77
339_L 657_G 1.484 0.76
120_R 264_Y 1.481 0.76
452_W 465_I 1.475 0.76
483_Y 487_M 1.473 0.76
489_R 493_Q 1.471 0.76
475_T 534_D 1.467 0.75
712_I 715_S 1.466 0.75
134_E 230_Q 1.465 0.75
536_S 603_R 1.458 0.75
104_N 118_A 1.451 0.74
581_N 596_N 1.451 0.74
8_S 91_Q 1.449 0.74
534_D 540_K 1.445 0.74
122_F 132_A 1.442 0.73
594_L 624_L 1.441 0.73
524_E 529_G 1.44 0.73
38_E 103_R 1.424 0.72
585_P 621_R 1.423 0.72
534_D 607_D 1.421 0.72
183_T 186_G 1.415 0.71
670_V 677_L 1.411 0.71
150_T 231_K 1.404 0.71
530_V 538_M 1.404 0.71
449_A 491_N 1.401 0.70
466_H 479_N 1.399 0.70
95_D 98_S 1.396 0.70
297_L 663_A 1.39 0.70
100_E 268_L 1.386 0.69
690_L 705_L 1.385 0.69
529_G 595_A 1.372 0.68
637_E 641_G 1.346 0.66
221_L 227_M 1.345 0.66
269_A 273_E 1.343 0.66
272_T 276_R 1.336 0.65
5_V 97_A 1.334 0.65
71_V 131_I 1.333 0.65
105_V 117_I 1.328 0.64
38_E 121_R 1.327 0.64
717_P 728_T 1.325 0.64
326_G 395_A 1.32 0.64
363_P 366_Q 1.32 0.64
364_G 388_E 1.32 0.64
326_G 330_H 1.314 0.63
668_A 692_F 1.313 0.63
277_Q 280_Q 1.311 0.63
183_T 376_G 1.308 0.63
132_A 264_Y 1.305 0.62
181_Y 185_D 1.302 0.62
30_Y 129_P 1.297 0.62
712_I 718_V 1.287 0.61
246_D 599_F 1.286 0.61
145_S 220_Q 1.283 0.60
237_W 240_D 1.279 0.60
340_L 344_L 1.273 0.60
125_A 274_N 1.27 0.59
719_S 728_T 1.27 0.59
116_T 140_L 1.269 0.59
464_E 535_D 1.267 0.59
475_T 540_K 1.266 0.59
394_F 655_A 1.244 0.57
537_F 603_R 1.242 0.57
139_P 142_A 1.242 0.57
139_P 144_A 1.235 0.56
259_C 267_L 1.23 0.56
108_R 577_V 1.23 0.56
488_A 491_N 1.228 0.55
108_R 114_G 1.228 0.55
450_K 512_R 1.225 0.55
475_T 536_S 1.22 0.55
158_N 325_E 1.218 0.55
120_R 268_L 1.218 0.55
58_G 383_S 1.212 0.54
392_P 455_R 1.21 0.54
446_L 499_A 1.208 0.54
103_R 121_R 1.207 0.54
9_E 24_M 1.205 0.53
328_K 469_I 1.201 0.53
39_E 609_S 1.2 0.53
9_E 90_W 1.2 0.53
143_D 222_H 1.199 0.53
597_L 619_A 1.198 0.53
269_A 616_G 1.198 0.53
359_W 444_L 1.198 0.53
679_L 692_F 1.197 0.53
165_D 517_L 1.196 0.52
294_Q 298_D 1.193 0.52
340_L 351_A 1.189 0.52
74_M 229_L 1.188 0.52
284_I 698_G 1.186 0.52
590_A 594_L 1.186 0.52
469_I 654_A 1.174 0.50
613_A 661_L 1.174 0.50
146_V 221_L 1.173 0.50
324_G 389_E 1.171 0.50
3_R 6_T 1.171 0.50
77_A 147_L 1.171 0.50
332_F 381_W 1.169 0.50
418_A 448_T 1.169 0.50
83_F 107_W 1.168 0.50
361_N 380_P 1.163 0.49
163_H 240_D 1.161 0.49
639_D 652_H 1.161 0.49
7_L 96_F 1.158 0.49
89_A 104_N 1.157 0.49
286_V 687_W 1.153 0.48
577_V 596_N 1.152 0.48
359_W 436_F 1.151 0.48
227_M 591_A 1.151 0.48
532_P 538_M 1.15 0.48
367_E 388_E 1.149 0.48
451_F 455_R 1.147 0.48
269_A 276_R 1.146 0.48
391_T 476_E 1.145 0.48
117_I 137_I 1.135 0.47
37_H 90_W 1.135 0.47
378_L 417_V 1.135 0.47
21_A 49_Y 1.134 0.47
382_E 392_P 1.132 0.47
335_T 354_L 1.127 0.46
447_E 450_K 1.127 0.46
414_H 455_R 1.127 0.46
203_Q 711_A 1.126 0.46
538_M 542_A 1.124 0.46
320_K 655_A 1.124 0.46
475_T 603_R 1.122 0.46
545_L 555_Q 1.119 0.45
626_T 685_E 1.119 0.45
583_M 632_W 1.119 0.45
680_N 723_N 1.116 0.45
436_F 444_L 1.116 0.45
81_E 379_F 1.116 0.45
562_S 569_M 1.105 0.44
533_Q 615_H 1.105 0.44
327_Y 573_K 1.105 0.44
79_N 139_P 1.105 0.44
271_S 668_A 1.104 0.44
712_I 729_V 1.103 0.44
362_L 377_A 1.102 0.44
532_P 596_N 1.102 0.44
609_S 636_T 1.101 0.44
699_C 718_V 1.101 0.44
50_L 317_I 1.099 0.43
608_S 639_D 1.096 0.43
122_F 264_Y 1.095 0.43
166_E 169_V 1.094 0.43
357_Y 383_S 1.093 0.43
425_I 428_W 1.088 0.42
392_P 469_I 1.088 0.42
331_V 534_D 1.085 0.42
337_V 422_W 1.083 0.42
421_A 424_V 1.083 0.42
445_L 494_Q 1.08 0.42
459_V 464_E 1.08 0.42
382_E 469_I 1.077 0.41
606_H 611_S 1.076 0.41
160_G 163_H 1.075 0.41
437_I 498_I 1.074 0.41
398_N 407_V 1.073 0.41
185_D 188_S 1.072 0.41
136_T 703_V 1.071 0.41
418_A 491_N 1.07 0.41
52_G 316_S 1.069 0.41
486_Y 557_I 1.066 0.40
670_V 694_L 1.065 0.40
355_L 441_G 1.055 0.39
424_V 436_F 1.054 0.39
445_L 498_I 1.054 0.39
610_L 652_H 1.054 0.39
412_A 475_T 1.052 0.39
365_A 377_A 1.052 0.39
103_R 124_S 1.051 0.39
304_L 339_L 1.051 0.39
608_S 652_H 1.05 0.39
536_S 540_K 1.049 0.39
320_K 326_G 1.049 0.39
412_A 607_D 1.047 0.39
382_E 413_E 1.047 0.39
679_L 710_I 1.046 0.39
702_Q 711_A 1.045 0.39
49_Y 325_E 1.044 0.38
391_T 558_L 1.044 0.38
234_W 259_C 1.043 0.38
456_A 512_R 1.041 0.38
319_A 436_F 1.04 0.38
146_V 349_T 1.04 0.38
378_L 414_H 1.039 0.38
59_K 383_S 1.039 0.38
532_P 603_R 1.037 0.38
106_V 116_T 1.035 0.38
332_F 472_D 1.035 0.38
33_L 48_M 1.035 0.38
7_L 711_A 1.032 0.37
384_A 390_E 1.032 0.37
465_I 488_A 1.031 0.37
332_F 573_K 1.031 0.37
330_H 381_W 1.028 0.37
146_V 218_S 1.027 0.37
326_G 412_A 1.026 0.37
532_P 536_S 1.023 0.37
330_H 382_E 1.023 0.37
691_S 702_Q 1.022 0.37
385_R 512_R 1.018 0.36
391_T 477_H 1.018 0.36
677_L 696_W 1.017 0.36
686_Q 689_Q 1.016 0.36
572_L 615_H 1.016 0.36
359_W 443_A 1.015 0.36
626_T 688_Q 1.014 0.36
63_N 385_R 1.014 0.36
608_S 611_S 1.014 0.36
475_T 532_P 1.014 0.36
50_L 359_W 1.011 0.36
279_W 362_L 1.009 0.35
379_F 448_T 1.009 0.35
326_G 477_H 1.007 0.35
31_L 117_I 1.007 0.35
417_V 469_I 1.006 0.35
555_Q 558_L 1.006 0.35
294_Q 317_I 1.005 0.35
672_V 696_W 1.005 0.35
462_R 519_E 1.003 0.35
31_L 235_I 1.003 0.35
95_D 270_A 1.003 0.35
124_S 130_L 1.002 0.35
561_Y 607_D 1.001 0.35
353_S 577_V 1 0.35
534_D 561_Y 1 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h54A20.9431000.286Contact Map0.685
2eabA20.92581000.601Contact Map0.446
2rdyA20.85171000.652Contact Map0.485
3rrsA20.886199.80.915Contact Map0.509
1v7wA10.863699.80.916Contact Map0.479
3qdeA20.887499.70.926Contact Map0.523
3c68A20.7868990.949Contact Map0.431
1ulvA10.858398.60.956Contact Map0.412
1lf6A20.766997.80.965Contact Map0.477
3w5mA10.896.90.97Contact Map0.453
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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