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OPENSEQ.org

SIXA - Phosphohistidine phosphatase SixA
UniProt: P76502 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14126
Length: 161 (156)
Sequences: 1194
Seq/Len: 7.65

SIXA
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
109_L 113_G 3.237 1.00
6_M 104_L 3.154 1.00
136_V 144_G 2.811 1.00
12_A 22_P 2.766 1.00
22_P 54_L 2.616 1.00
57_E 75_V 2.488 1.00
19_S 52_P 2.464 1.00
5_I 116_V 2.445 1.00
128_F 134_A 2.332 1.00
95_L 103_V 2.303 1.00
100_V 103_V 2.114 1.00
5_I 112_V 2.041 1.00
17_S 20_V 1.983 1.00
50_V 60_L 1.961 1.00
48_V 60_L 1.904 1.00
4_F 102_S 1.881 1.00
6_M 133_I 1.857 1.00
53_F 56_A 1.851 1.00
9_G 31_S 1.763 1.00
50_V 75_V 1.722 1.00
107_S 112_V 1.702 1.00
37_W 41_Q 1.668 1.00
138_L 144_G 1.64 1.00
6_M 63_V 1.613 1.00
4_F 133_I 1.577 1.00
134_A 146_F 1.569 1.00
107_S 111_L 1.555 1.00
31_S 35_A 1.538 1.00
53_F 80_T 1.521 1.00
50_V 57_E 1.499 0.99
45_I 104_L 1.484 0.99
10_D 130_T 1.471 0.99
35_A 63_V 1.457 0.99
10_D 24_T 1.456 0.99
54_L 58_Q 1.437 0.99
116_V 134_A 1.427 0.99
88_V 111_L 1.415 0.99
11_A 24_T 1.355 0.99
25_T 28_C 1.354 0.99
58_Q 61_E 1.345 0.99
132_A 149_Q 1.319 0.98
38_L 133_I 1.311 0.98
129_T 149_Q 1.309 0.98
19_S 53_F 1.26 0.98
2_Q 137_T 1.256 0.97
28_C 62_E 1.245 0.97
135_S 148_W 1.243 0.97
137_T 145_T 1.229 0.97
9_G 111_L 1.222 0.97
83_G 111_L 1.193 0.96
128_F 132_A 1.182 0.96
4_F 135_S 1.179 0.96
11_A 153_C 1.178 0.96
78_E 94_A 1.173 0.96
47_R 74_E 1.159 0.95
79_L 82_C 1.126 0.94
49_L 103_V 1.111 0.94
63_V 106_I 1.109 0.94
20_V 54_L 1.108 0.94
53_F 111_L 1.106 0.94
31_S 131_S 1.103 0.94
12_A 24_T 1.091 0.93
82_C 111_L 1.08 0.93
10_D 26_N 1.077 0.92
22_P 58_Q 1.069 0.92
85_V 118_E 1.055 0.91
11_A 127_M 1.052 0.91
56_A 130_T 1.042 0.91
10_D 30_E 1.015 0.89
78_E 91_Y 1.014 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1ujcA111000.284Contact Map0.767
3f2iA60.99381000.319Contact Map0.766
2rflA80.95031000.343Contact Map0.866
4hbzA10.9131000.356Contact Map0.714
3fjyA20.975299.90.394Contact Map0.568
1fztA10.944199.90.472Contact Map0.563
2a6pA20.993899.90.477Contact Map0.574
4ij5A20.968999.90.479Contact Map0.763
3eozA20.975299.90.48Contact Map0.752
1h2eA10.968999.90.48Contact Map0.601

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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