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OPENSEQ.org
YFBR - 5'-nucleotidase YfbR
UniProt: P76491 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14102
Length: 199 (194)
Sequences: 226
Seq/Len: 1.16
YFBR
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
67_Y 116_F 2.599 1.00
48_K 54_G 2.319 0.99
13_L 30_V 2.079 0.97
51_K 111_E 1.935 0.96
50_R 115_I 1.934 0.96
5_H 185_S 1.791 0.93
34_S 37_V 1.768 0.92
165_A 169_A 1.753 0.92
45_A 61_I 1.751 0.92
40_V 139_L 1.733 0.91
12_R 22_M 1.726 0.91
160_K 164_E 1.688 0.90
60_R 64_L 1.635 0.87
143_L 183_V 1.625 0.87
58_A 117_A 1.619 0.87
7_F 43_A 1.618 0.87
48_K 174_E 1.591 0.85
8_A 12_R 1.57 0.84
67_Y 119_L 1.518 0.82
118_P 180_E 1.488 0.80
41_A 62_A 1.436 0.76
19_W 22_M 1.408 0.74
56_V 131_S 1.399 0.74
44_L 136_A 1.393 0.73
56_V 128_E 1.386 0.73
31_S 194_S 1.342 0.69
39_M 82_V 1.326 0.68
35_L 39_M 1.321 0.67
30_V 143_L 1.318 0.67
12_R 19_W 1.312 0.67
65_A 156_F 1.257 0.62
40_V 140_C 1.254 0.61
88_Q 91_Q 1.236 0.60
61_I 129_E 1.223 0.59
7_F 100_A 1.222 0.59
30_V 73_V 1.222 0.59
39_M 87_S 1.221 0.58
145_C 190_L 1.218 0.58
39_M 85_F 1.217 0.58
2_K 124_A 1.216 0.58
19_W 73_V 1.21 0.57
143_L 167_L 1.208 0.57
50_R 114_D 1.196 0.56
135_Q 175_M 1.195 0.56
55_N 180_E 1.184 0.55
31_S 63_L 1.182 0.55
53_G 113_R 1.181 0.55
73_V 183_V 1.176 0.54
95_A 163_L 1.166 0.53
41_A 58_A 1.16 0.53
154_N 179_M 1.159 0.53
14_K 147_E 1.159 0.53
78_L 93_Y 1.157 0.52
132_L 167_L 1.143 0.51
111_E 181_I 1.136 0.50
73_V 104_L 1.132 0.50
179_M 183_V 1.13 0.50
116_F 175_M 1.129 0.50
166_T 170_R 1.12 0.49
1_M 74_L 1.118 0.49
6_F 23_R 1.109 0.48
59_E 64_L 1.099 0.47
30_V 188_L 1.098 0.47
31_S 59_E 1.089 0.46
26_R 70_A 1.089 0.46
57_N 61_I 1.089 0.46
145_C 159_A 1.073 0.44
71_S 94_K 1.064 0.43
1_M 123_H 1.063 0.43
50_R 58_A 1.063 0.43
30_V 65_A 1.062 0.43
13_L 50_R 1.061 0.43
49_N 100_A 1.06 0.43
20_P 140_C 1.057 0.43
79_P 159_A 1.055 0.43
9_H 20_P 1.053 0.42
126_S 129_E 1.048 0.42
125_Y 130_K 1.045 0.42
97_E 156_F 1.043 0.41
149_L 183_V 1.042 0.41
3_Q 157_L 1.034 0.41
15_L 25_V 1.033 0.40
98_K 117_A 1.033 0.40
138_A 167_L 1.025 0.40
142_Y 164_E 1.023 0.40
29_N 136_A 1.022 0.39
54_G 174_E 1.014 0.39
132_L 183_V 1.014 0.39
52_F 177_Y 1.01 0.38
43_A 47_I 1.008 0.38
61_I 128_E 1.008 0.38
101_Q 122_E 1.007 0.38
92_E 143_L 1.007 0.38
67_Y 84_Y 1.007 0.38
117_A 161_T 1.001 0.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2paqA211000.416Contact Map0.471
3mzoA30.9951000.431Contact Map0.355
4l1jA20.92461000.546Contact Map0.349
1xx7A60.86931000.551Contact Map0.306
3kh1A20.92461000.57Contact Map0.307
2cqzA60.86931000.577Contact Map0.283
1ynbA30.8091000.616Contact Map0.387
2gz4A40.86431000.661Contact Map0.316
2pq7A10.884496.40.913Contact Map0.338
2qgsA20.849296.40.913Contact Map0.361
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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